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Cited by 51Schizophrenia research and treatmentMental Health and PsychiatryMental Health Research Topics

The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.

Patterns of stress in schizophrenia

Open access
Betensky, Julia D., Robinson, Delbert G., Gunduz-Bruce, Handan, Sevy, Serge, Lencz, Todd, Kane, John M., Malhotra, Anil K., Miller, Rachel, McCormack, Joanne, Bilder, Robert M., Szeszko, Philip R.·2008·Psychiatry Research
DOI 10.1016/j.psychres.2007.06.001PMC PMC2487675
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Abstract

Although it is widely recognized that stress plays a key role in the pathophysiology of schizophrenia, little is known regarding the particular types of stress patients experience. Less is known about the interplay among stressful events, personality mediators, and emotional responses. In this study, we investigated 10 stress dimensions in 29 patients with schizophrenia and 36 healthy volunteers using the Derogatis Stress Profile (DSP), and the relationship between these dimensions and symptoms in patients. Overall, patients had an approximate 0.75 standard deviation increase in stress compared with healthy volunteers. Significant increases in stress among patients compared with healthy volunteers were observed specifically in areas related to domestic environment, driven behavior, and depression, but not in health, attitude posture, time pressure, relaxation potential, role definition, hostility, or anxiety. More DSP-rated depression among patients correlated significantly with greater negative symptom severity. Patients with a shorter duration of antipsychotic drug exposure had significantly greater hostility than did patients with a longer duration of exposure, but did not differ in any other dimension. Continued investigation of domestic environmental stressors, driven behavior, and depression may be useful in identifying high-risk groups, and understanding symptom exacerbation and precipitants of relapse in patients already diagnosed with schizophrenia.

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Crossref · 10.1016/j.psychres.2007.06.001

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Metadata

Authors
Betensky, J. D., Robinson, D. G., Gunduz-Bruce, H., Sevy, S., Lencz, T., Kane, J. M., Malhotra, A. K., Miller, R., McCormack, J., Bilder, R. M., & Szeszko, P. R.
Affiliations
  • Northwell Health (US)
  • Albert Einstein College of Medicine (US)
  • University of California, Los Angeles (US)
Corresponding author
Szeszko, Philip R.
ORCID
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
2008-07
Volume
160
Issue
1
Pages
38-46
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/j.psychres.2007.06.001
PMC
PMC2487675
OpenAlex
W2113889320
Cited by
51
References
66
Citations by year
2026: 4 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 1 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 4
FWCI
2.57
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (MH 60004, P30MH060575, MH60374, K01MH001990, MH01990, R01MH060374, R01MH060004, MH 60575)
  • National Institute on Drug Abuse (K23DA015541, DA-015541)
  • National Center for Research Resources (M01RR018535)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords
schizophrenia, stress, stress dimensions, depression, negative symptoms, hostility, relapse, symptom exacerbation
MeSH terms
Adult, Analysis of Variance, Depressive Disorder, Family, Female, Hostility, Humans, Male, Personality Inventory, Psychiatric Status Rating Scales, Psychometrics, Recurrence, Risk Factors, Schizophrenia, Schizophrenic Psychology, Severity of Illness Index, Social Environment, Stress, Psychological, Antipsychotic Agents, Comorbidity, Control Groups

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