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Cited by 118Tryptophan and brain disordersStress Responses and CortisolTreatment of Major Depression

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Increased plasma levels of 8-iso-PGF2α and IL-6 in an elderly population with depression

Dimopoulos, Nikolaos, Piperi, Christina, Psarra, Vassiliki, Lea, Robert W., Kalofoutis, Anastasios·2008·Psychiatry Research
DOI 10.1016/j.psychres.2007.07.019
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Abstract

Oxidative damage and immune-inflammatory activation have been suggested to play a role in depression. The purpose of the study was to investigate possible associations and interactions of these pathophysiological mechanisms in geriatric depression by determining the levels of plasma 8-iso-prostaglandin F(2alpha) (8-iso-PGF(2alpha)) and interleukin-6 (IL-6) in elderly depressed individuals. Subjects over 60 years of age with depression and controls were randomly selected from a population in the community after screening with the Geriatric Depression Scale. Plasma concentrations of 8-iso-PGF2alpha and IL-6 were measured in both groups. Depressed patients had significantly higher mean (+/-S.D.) 8-iso-PGF2alpha levels compared to healthy controls (245.01+/-179.92 pg/ml vs 97.64+/-42.72 pg/ml, respectively). Similarly, the same groups demonstrated significantly elevated IL-6 levels compared with controls (58.73+/-39.90 pg/ml vs 15.41+/-9.27 pg/ml). This study indicates an association between increased levels of plasma 8-iso-PGF2alpha and IL-6 with depressive symptomatology in elderly individuals and indicates the necessity for further investigation, possibly within the framework of an integrated involvement of oxidative damage and inflammation in the pathophysiology of depression in the elderly.

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Crossref · 10.1016/j.psychres.2007.07.019

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Metadata

Authors
Dimopoulos, N., Piperi, C., Psarra, V., Lea, R. W., & Kalofoutis, A.
Affiliations
  • National and Kapodistrian University of Athens (GR)
  • University of Lancashire (GB)
Corresponding author
Dimopoulos, Nikolaos
ORCID
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
2008-10
Volume
161
Issue
1
Pages
59-66
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/j.psychres.2007.07.019
OpenAlex
W2013247338
Cited by
118
References
40
Citations by year
2025: 7 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 11 · 2013: 8 · 2012: 8
FWCI
2.12
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
  • CLOK (University of Central Lancashire) (acceptedVersion)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
geriatric depression, 8-isoprostane, interleukin-6, oxidative stress, inflammation, plasma biomarkers, older adults, depression pathophysiology, lipid peroxidation
MeSH terms
Age Factors, Aged, Depressive Disorder, Female, Humans, Inflammation, Male, Middle Aged, Reference Values, Risk Factors, Lipid Peroxidation, Dinoprost, Interleukin-8, Oxidative Stress

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