Cited by 118Tryptophan and brain disordersStress Responses and CortisolTreatment of Major Depression

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Increased plasma levels of 8-iso-PGF2α and IL-6 in an elderly population with depression

Dimopoulos, Nikolaos, Piperi, Christina, Psarra, Vassiliki, Lea, Robert W., Kalofoutis, Anastasios·2008·Psychiatry Research

DOI 10.1016/j.psychres.2007.07.019

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Abstract

Oxidative damage and immune-inflammatory activation have been suggested to play a role in depression. The purpose of the study was to investigate possible associations and interactions of these pathophysiological mechanisms in geriatric depression by determining the levels of plasma 8-iso-prostaglandin F(2alpha) (8-iso-PGF(2alpha)) and interleukin-6 (IL-6) in elderly depressed individuals. Subjects over 60 years of age with depression and controls were randomly selected from a population in the community after screening with the Geriatric Depression Scale. Plasma concentrations of 8-iso-PGF2alpha and IL-6 were measured in both groups. Depressed patients had significantly higher mean (+/-S.D.) 8-iso-PGF2alpha levels compared to healthy controls (245.01+/-179.92 pg/ml vs 97.64+/-42.72 pg/ml, respectively). Similarly, the same groups demonstrated significantly elevated IL-6 levels compared with controls (58.73+/-39.90 pg/ml vs 15.41+/-9.27 pg/ml). This study indicates an association between increased levels of plasma 8-iso-PGF2alpha and IL-6 with depressive symptomatology in elderly individuals and indicates the necessity for further investigation, possibly within the framework of an integrated involvement of oxidative damage and inflammation in the pathophysiology of depression in the elderly.

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Authors: Dimopoulos, N., Piperi, C., Psarra, V., Lea, R. W., & Kalofoutis, A.
Affiliations: National and Kapodistrian University of Athens (GR)
University of Lancashire (GB)
Corresponding author: Dimopoulos, Nikolaos
ORCID: Piperi, Christina
Psarra, Vassiliki
Lea, Robert W.
Venue: Psychiatry Research
Publisher: Elsevier BV
Published: 2008-10
Volume: 161
Issue: 1
Pages: 59-66
ISSN: 0165-1781 (ISSN-L)
DOI: 10.1016/j.psychres.2007.07.019
OpenAlex: W2013247338
Cited by: 118
References: 40
Citations by year: 2025: 7 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 11 · 2013: 8 · 2012: 8
FWCI: 2.12
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Psychiatry Research (publishedVersion)
PubMed (publishedVersion)
CLOK (University of Central Lancashire) (acceptedVersion)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: geriatric depression, 8-isoprostane, interleukin-6, oxidative stress, inflammation, plasma biomarkers, older adults, depression pathophysiology, lipid peroxidation
MeSH terms: Age Factors, Aged, Depressive Disorder, Female, Humans, Inflammation, Male, Middle Aged, Reference Values, Risk Factors, Lipid Peroxidation, Dinoprost, Interleukin-8, Oxidative Stress

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Increased plasma levels of 8-iso-PGF2α and IL-6 in an elderly population with depression

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