The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Increased plasma levels of 8-iso-PGF2α and IL-6 in an elderly population with depression
Abstract
Oxidative damage and immune-inflammatory activation have been suggested to play a role in depression. The purpose of the study was to investigate possible associations and interactions of these pathophysiological mechanisms in geriatric depression by determining the levels of plasma 8-iso-prostaglandin F(2alpha) (8-iso-PGF(2alpha)) and interleukin-6 (IL-6) in elderly depressed individuals. Subjects over 60 years of age with depression and controls were randomly selected from a population in the community after screening with the Geriatric Depression Scale. Plasma concentrations of 8-iso-PGF2alpha and IL-6 were measured in both groups. Depressed patients had significantly higher mean (+/-S.D.) 8-iso-PGF2alpha levels compared to healthy controls (245.01+/-179.92 pg/ml vs 97.64+/-42.72 pg/ml, respectively). Similarly, the same groups demonstrated significantly elevated IL-6 levels compared with controls (58.73+/-39.90 pg/ml vs 15.41+/-9.27 pg/ml). This study indicates an association between increased levels of plasma 8-iso-PGF2alpha and IL-6 with depressive symptomatology in elderly individuals and indicates the necessity for further investigation, possibly within the framework of an integrated involvement of oxidative damage and inflammation in the pathophysiology of depression in the elderly.
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“Dimopoulos et al. (2008) have found that F2-isoprostanes (F2-iso) circulatory levels were increased in major depressive patients and were significantly correlated with the severity of depressive symptoms [50].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [50]
Citations
Cites
Microglia as a source and target of cytokines
Hanisch, U. (2002) · Glia · doi:10.1002/glia.10161 · Cited by 1,645
Sickness behavior as a new target for drug development
Kent, S., Bluthé, R.-M., Kelley, K. W., & Dantzer, R. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90012-u · Cited by 867
Cytokines and the Brain: Implications for Clinical Psychiatry
Kronfol, Z., & Remick, D. G. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.683 · Cited by 784
Passage of cytokines across the blood–brain barrier
Banks, W. A., Kastin, A. J., & Broadwell, R. D. (1996) · Neuroimmunomodulation · doi:10.1159/000097202 · Cited by 778
Maes, M., Meltzer, H. Y., Bosmans, E., Bergmans, R., Vandoolaeghe, E., Ranjan, R., & Desnyder, R. (1995) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00028-l · Cited by 622
Major Depression and Activation of The Inflammatory Response System
Maes, M. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_2 · Cited by 617
Modulation of Oxidant Stress In Vivo in Chronic Cigarette Smokers
Reilly, M., Delanty, N., Lawson, J. A., & FitzGerald, G. A. (1996) · Circulation · doi:10.1161/01.cir.94.1.19 · Cited by 614
Platelet Activation in Obese Women
Davı̀, G., Guagnano, M. T., Ciabattoni, G., Basili, S., Falco, A., Marinopiccoli, M., Nutini, M., Sensi, S., & Patrono, C. (2002) · JAMA · doi:10.1001/jama.288.16.2008 · Cited by 542
Khanzode, S. D., Dakhale, G. N., Khanzode, S. S., Saoji, A., & Palasodkar, R. (2003) · Redox Report · doi:10.1179/135100003225003393 · Cited by 458
Rating scales in mental health
Sajatovic, M., & Ramirez, L. (2001) · Choice Reviews Online · doi:10.5860/choice.50-5349 · Cited by 437
Zhang, R., Brennan, M.-L., Shen, Z., MacPherson, J. C., Schmitt, D., Molenda, C. E., & Hazen, S. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209124200 · Cited by 432
The Geriatric Depression Scale: A Review of Its Development and Utility
Montorio, I., & Izal, M. (1996) · International Psychogeriatrics · doi:10.1017/s1041610296002505 · Cited by 401
Interleukin-1 beta: a putative mediator of HPA axis hyperactivity in major depression?
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.8.1189 · Cited by 364
In Vivo Formation of 8-Epi-Prostaglandin F2αIs Increased in Hypercholesterolemia
Davı̀, G., Alessandrini, P., Mezzetti, A., Minotti, G., Bucciarelli, T., Costantini, F., Cipollone, F., Bon, G. B., Ciabattoni, G., & Patrono, C. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.3230 · Cited by 350
Cytokines: abnormalities in major depression and implications for pharmacological treatment
O’Brien, S. M., Scott, L. V., & Dinan, T. G. (2004) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.609 · Cited by 327
Hayley, S., Poulter, M. O., Merali, Z., & Anisman, H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.051 · Cited by 324
Morrow, J. D., Awad, J. A., Kato, T., Takahashi, K., Badr, K. F., Roberts, L. J., & Burk, R. F. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116143 · Cited by 319
Tselepis, A. D., & Chapman, M. J. (2002) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(02)00045-4 · Cited by 314
Increased Serum Levels of 8-Hydroxy-2′-Deoxyguanosine in Clinical Depression
Forlenza, M. J., & Miller, G. E. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000195780.37277.2a · Cited by 309
Psychoneuroimmunology and the cytokine action in the CNS: Implications for psychiatric disorders
Müller, N., & Ackenheil, M. (1998) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(97)00179-6 · Cited by 305
Cylooxygenase-dependent Formation of the Isoprostane, 8-Epi Prostaglandin F2α
Praticò, D., Lawson, J. A., & FitzGerald, G. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.17.9800 · Cited by 266
Detecting depression in elderly medical inpatients.
Rapp, S. R., Parisi, S. A., Walsh, D. A., & Wallace, C. E. (1988) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.56.4.509 · Cited by 237
Validating the GDS Depression Screen in the Nursing Home
McGivney, S. A., Mulvihill, M., & Taylor, B. (1994) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1994.tb04969.x · Cited by 231
Detecting depression in elderly medical inpatients.
Rapp, S. R., Parisi, S. A., Walsh, D. A., et al. (1988) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.56.4.509 · Cited by 194
Rating Scales in Mental Health
Sajatovic, M. (2012) · Johns Hopkins University Press eBooks · doi:10.56021/9781421406664 · Cited by 192
Stress, depression and immunity: the role of defense and coping styles
Olff, M. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(98)00139-5 · Cited by 178
Major depressive disorder is associated with elevated monocyte counts
Seidel, A., Arolt, V., Hunstiger, M., Rink, L., Behnisch, A., & Kirchner, H. (1996) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1996.tb09849.x · Cited by 123
F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases
Praticò, D., Rokach, J., Lawson, J., & FitzGerald, G. A. (2004) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2003.09.012 · Cited by 120
Murphy, P. G., Borthwick, L. A., Altares, M., Gauldie, J., Kaplan, D. R., & Richardson, P. M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00074.x · Cited by 114
Depression and possible cancer risk due to oxidative DNA damage
Irie, M., Miyata, M., & Kasai, H. (2005) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.01.009 · Cited by 112
Platelet Activation and Lipid Peroxidation in Patients With Acute Ischemic Stroke
van Kooten, F., Ciabattoni, G., Patrono, C., Dippel, D. W. J., & Koudstaal, P. J. (1997) · Stroke · doi:10.1161/01.str.28.8.1557 · Cited by 100
Assessment of elderly people in general practice. 1. Social circumstances and mental state.
Iliffe, S., Haines, A., Gallivan, S., Booroff, A., GOLDENBERG, E., & Morgan, P. (1991) · Europe PMC (PubMed Central) · Cited by 95
Mehrabi, M. R. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00108-x · Cited by 58
Increase of isoprostane 8-epi-PGF2 αafter restarting smoking
Chehne, F., Oguogho, A., Lupattelli, G., Budinsky, A. C., Palumbo, B., & Sinzinger, H. F. (2001) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0277 · Cited by 45
Raj, A. (2004) · Postgraduate Medicine · doi:10.3810/pgm.2004.06.1534 · Cited by 43
Assessment of elderly people in general practice
Maycock, C. H., Kent, C., Shorney, J. S., & Russell, D. (1991) · Europe PMC (PubMed Central) · Cited by 39
Late-life depression. How to identify its symptoms and provide effective treatment.
Sable, J. A., Dunn, L. B., & Zisook, S. (2002) · PubMed · Cited by 33
Mu, X., Staiano‐Coico, L., & Higgins, P. J. (1998) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199801)174:1 · Cited by 30
Waddington, E. I., Croft, K. D., Clarnette, R., Mori, T. A., & Martins, R. N. (1999) · UWA Profiles and Research Repository (UWA) · Cited by 29
Suppression of oxidative stress after transient focal ischemia in interleukin-1 knock out mice
Ohtaki, H., Takaki, A., Li, Y., Dohi, K., Nakamachi, T., Matsunaga, M., Horai, R., Asano, M., Iwakura, Y., & Shioda, S. (2003) · Springer eBooks · doi:10.1007/978-3-7091-0651-8_41 · Cited by 28
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Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Maes, M., Galecki, P., Chang, Y. S., & Berk, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.05.004 · Cited by 1,140
Leonard, B., & Maes, M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.005 · Cited by 805
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Black, C. N., Bot, M., Scheffer, P. G., Cuijpers, P., & Penninx, B. W. J. H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.025 · Cited by 711
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Metadata
- Authors
- Dimopoulos, N., Piperi, C., Psarra, V., Lea, R. W., & Kalofoutis, A.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- University of Lancashire (GB)
- Corresponding author
- Dimopoulos, Nikolaos
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 161
- Issue
- 1
- Pages
- 59-66
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2013247338
- Cited by
- 118
- References
- 40
- Citations by year
- 2025: 7 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 11 · 2013: 8 · 2012: 8
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- CLOK (University of Central Lancashire) (acceptedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- geriatric depression, 8-isoprostane, interleukin-6, oxidative stress, inflammation, plasma biomarkers, older adults, depression pathophysiology, lipid peroxidation
- MeSH terms
- Age Factors, Aged, Depressive Disorder, Female, Humans, Inflammation, Male, Middle Aged, Reference Values, Risk Factors, Lipid Peroxidation, Dinoprost, Interleukin-8, Oxidative Stress
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