The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Increased plasma levels of 8-iso-PGF2α and IL-6 in an elderly population with depression
Abstract
Oxidative damage and immune-inflammatory activation have been suggested to play a role in depression. The purpose of the study was to investigate possible associations and interactions of these pathophysiological mechanisms in geriatric depression by determining the levels of plasma 8-iso-prostaglandin F(2alpha) (8-iso-PGF(2alpha)) and interleukin-6 (IL-6) in elderly depressed individuals. Subjects over 60 years of age with depression and controls were randomly selected from a population in the community after screening with the Geriatric Depression Scale. Plasma concentrations of 8-iso-PGF2alpha and IL-6 were measured in both groups. Depressed patients had significantly higher mean (+/-S.D.) 8-iso-PGF2alpha levels compared to healthy controls (245.01+/-179.92 pg/ml vs 97.64+/-42.72 pg/ml, respectively). Similarly, the same groups demonstrated significantly elevated IL-6 levels compared with controls (58.73+/-39.90 pg/ml vs 15.41+/-9.27 pg/ml). This study indicates an association between increased levels of plasma 8-iso-PGF2alpha and IL-6 with depressive symptomatology in elderly individuals and indicates the necessity for further investigation, possibly within the framework of an integrated involvement of oxidative damage and inflammation in the pathophysiology of depression in the elderly.
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“Dimopoulos et al. (2008) have found that F2-isoprostanes (F2-iso) circulatory levels were increased in major depressive patients and were significantly correlated with the severity of depressive symptoms [50].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [50]
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Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Maes, M., Galecki, P., Chang, Y. S., & Berk, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.05.004 · Cited by 1,140
Leonard, B., & Maes, M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.005 · Cited by 805
Is depression associated with increased oxidative stress? A systematic review and meta-analysis
Black, C. N., Bot, M., Scheffer, P. G., Cuijpers, P., & Penninx, B. W. J. H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.025 · Cited by 711
Ng, A., Tam, W. W., Zhang, M. W., Ho, C. S., Husain, S. F., McIntyre, R. S., & Ho, R. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-30487-6 · Cited by 572
Metadata
- Authors
- Dimopoulos, N., Piperi, C., Psarra, V., Lea, R. W., & Kalofoutis, A.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- University of Lancashire (GB)
- Corresponding author
- Dimopoulos, Nikolaos
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 161
- Issue
- 1
- Pages
- 59-66
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2013247338
- Cited by
- 118
- References
- 40
- Citations by year
- 2025: 7 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 11 · 2013: 8 · 2012: 8
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- CLOK (University of Central Lancashire) (acceptedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- geriatric depression, 8-isoprostane, interleukin-6, oxidative stress, inflammation, plasma biomarkers, older adults, depression pathophysiology, lipid peroxidation
- MeSH terms
- Age Factors, Aged, Depressive Disorder, Female, Humans, Inflammation, Male, Middle Aged, Reference Values, Risk Factors, Lipid Peroxidation, Dinoprost, Interleukin-8, Oxidative Stress
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