Association of Interleukin‐6 and Other Biologic Variables with Depression in Older People Living in the Community

Dentino, Andrew N.; Pieper, Carl F.; Rao, K. Murali K.; Currie, Mark S.; Harris, Tamara; Blazer, Dan G.; Cohen, Harvey Jay

doi:10.1111/j.1532-5415.1999.tb01894.x

Cited by 287Tryptophan and brain disordersStress Responses and CortisolTreatment of Major Depression

Association of Interleukin‐6 and Other Biologic Variables with Depression in Older People Living in the Community

Dentino, Andrew N., Pieper, Carl F., Rao, K. Murali K., Currie, Mark S., Harris, Tamara, Blazer, Dan G., Cohen, Harvey Jay·1999·Journal of the American Geriatrics Society

DOI 10.1111/j.1532-5415.1999.tb01894.x

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Abstract

OBJECTIVES: The prevalence of depression increases with age, as does the prevalence of higher levels of the cytokine interleukin‐6 (IL‐6). This analysis was performed to determine the association between increased levels of this cytokine and depression in a population‐based sample. DESIGN: Cross‐sectional cohort study. SETTING: Rural and urban counties in North Carolina. PARTICIPANTS: Community‐dwelling older people. MEASUREMENTS: The association between IL‐6 and other biologic variables with self‐report depression was examined in 1686 persons aged 70 years and older in the third in‐person survey wave (1991) of the Duke Established Population for Epidemiologic Studies of the Elderly (EPESE). Bivariate associations were established by the Spearman correlation, adjusted for age. A stepwise linear logistic regression model was used to derive a final model to assess multivariable effects on CES‐D scores. RESULTS: Depression was correlated with IL‐6 ( P = .011), D‐Dimer ( P = .017), alpha‐l‐globulin ( P = .023), alphas‐2‐globulin ( P = .002), and beta globulin ( P = .012). After controlling for age, race, and gender, IL‐6 levels remained the only biologic variable significantly associated with depression ( P = .035). CONCLUSION: These data suggest that the inflammatory marker, IL‐6, is associated with depression in older people in this cross‐sectional study. These results are compatible with the hypothesis of cytokine (IL‐6) stimulation in geriatric depression as part of an overall immunoendocrine dysregulation.

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Production of IL-6 and other proinflammatory cytokines can be directly stimulated by depression and other negative emotions and stressful experiences.
“Production of IL-6 and other proinflammatory cytokines can be directly stimulated by depression and other negative emotions and stressful experiences (16-20).”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [16]

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Self-citation

Inflammatory Proteins and Depression in the Elderly
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Self-citation
Inflammatory markers in late-life depression: Results from a population-based study
Bremmer, M. A., Beekman, A. T. F., Deeg, D. J. H., Penninx, B. W. J. H., Dik, M. G., Hack, C. E., & Hoogendijk, W. J. G. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.07.002 · Cited by 326 · see citing works

Authors: Dentino, A. N., Pieper, C. F., Rao, K. M. K., Currie, M. S., Harris, T., Blazer, D. G., & Cohen, H. J.
Affiliations: Duke University (US)
National Institutes of Health (US)
Corresponding author: Cohen, Harvey Jay
ORCID: Dentino, Andrew N.
Pieper, Carl F.
Harris, Tamara
Cohen, Harvey Jay
Venue: Journal of the American Geriatrics Society
Publisher: Wiley
Published: 1999-01
Volume: 47
Issue: 1
Pages: 6-11
ISSN: 0002-8614 (ISSN-L)
1532-5415
DOI: 10.1111/j.1532-5415.1999.tb01894.x
OpenAlex: W2010664010
Cited by: 287
References: 36
Citations by year: 2026: 2 · 2025: 5 · 2024: 2 · 2022: 7 · 2021: 3 · 2020: 9 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 12 · 2013: 16 · 2012: 14
FWCI: 4.17
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5960 d)
Locations: Journal of the American Geriatrics Society (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (5P60-AG11268, N01‐AG12102, P60AG011268)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: interleukin-6, depression, older adults, community-dwelling older adults, cytokines, inflammation, D-dimer, serum globulin, geriatric depression
MeSH terms: Aged, Alpha-Globulins, Analysis of Variance, Beta-Globulins, Cross-Sectional Studies, Depression, Female, Fibrin Fibrinogen Degradation Products, Follow-Up Studies, Health Surveys, Humans, Male, North Carolina, Biomarkers, Interleukin-6, Prevalence, Linear Models, Age Distribution, Statistics, Nonparametric

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Association of Interleukin‐6 and Other Biologic Variables with Depression in Older People Living in the Community

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