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Cited by 54Schizophrenia research and treatmentCognitive Abilities and TestingNeural and Behavioral Psychology Studies

Working memory impairments in first-episode psychosis and chronic schizophrenia

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Zanello, Adriano, Curtis, Logos, Badan Bâ, Maryse, Merlo, Marco C.G.·2009·Psychiatry Research
DOI 10.1016/j.psychres.2007.10.006
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Abstract

Working memory (WM) impairments are core cognitive deficits in patients with schizophrenia linked to prefrontal cortical dysfunctions. Determining the differences between early phases of illness allows a better understanding of its course and constitutes an important guide for treatment. The present cross-sectional study examined differences of working memory functions between 33 first-episode and 29 chronic schizophrenic patients, as well as 64 healthy controls. On the basis of a two-back visual-verbal computerized working memory task, reaction time was slower and accuracy was worse in both patient groups than in controls. Test variables, however, were not significantly different between the patient groups, suggesting stability of the deficits over time. Effect size accuracy variables nevertheless showed larger deficits in chronic patients.

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  • Larger deficits in working memory exist in elderly versus first-episode people with schizophrenia.

    “Larger deficits in working memory have been shown to exist in elderly vs first-episode people with schizophrenia, while worse recall of material in episodic memory, changes in select time-based measures of problem solving and fine motor dexterity have all been associated with greater length of illness.61,62”

    From Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far? (2013) · cites this paper as [61]

  • Cognitive function is age dependent in healthy controls and schizophrenia samples.

    “Although cognitive impairments are generally stable over relatively short periods of time in the longitudinal course of schizophrenia58–60 cognitive function is age dependent in healthy controls and schizophrenia samples.”

    From Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far? (2013) · cites this paper as [61]

  • Worse recall of material in episodic memory, changes in select time-based measures of problem solving, and fine motor dexterity have been associated with greater length of illness in schizophrenia.

    “Larger deficits in working memory have been shown to exist in elderly vs first-episode people with schizophrenia, while worse recall of material in episodic memory, changes in select time-based measures of problem solving and fine motor dexterity have all been associated with greater length of illness.61,62”

    From Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far? (2013) · cites this paper as [61]

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Authors
Zanello, A., Curtis, L., Badan Bâ, M., & Merlo, M. C. G.
Affiliations
University Hospital of Geneva (CH)
Corresponding author
Merlo, Marco C.G.
ORCID
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
2009-01
Volume
165
Issue
1-2
Pages
10-18
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/j.psychres.2007.10.006
OpenAlex
W2099282366
Cited by
54
References
56
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 9 · 2012: 1
FWCI
1.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
working memory, schizophrenia, first-episode psychosis, chronic schizophrenia, cognitive impairment, prefrontal cortex, reaction time, response accuracy, two-back task
MeSH terms
Acute Disease, Adolescent, Adult, Attention, Chronic Disease, Cognition Disorders, Female, Humans, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Psychotic Disorders, Reaction Time, Schizophrenia, Schizophrenic Psychology, Case-Control Studies, Young Adult

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