Cited by 280Schizophrenia research and treatmentMental Health and PsychiatryDementia and Cognitive Impairment Research

Cognition in Schizophrenia: Impairments, Determinants, and Functional Importance

Bowie, Christopher R., Harvey, Philip D.·2005·Psychiatric Clinics of North America

Abstract

Recent findings support and add to earlier findings of cognitive dysfunction in schizophrenia. Deficits across neurocognitive domains such as attention, working memory, language skills, and executive functioning tend to be moderate, with the most pronounced deficits found in verbal learning and memory. All these neurocognitive domains are related to adaptive and social skills, with executive functions and verbal learning and memory showing more variance across more domains than other neuro-cognitive variables. Negative symptoms and neurocognitive domains, although correlated, are distinct and have differential pathways of change with treatment. General psychopathology symptoms, such as depression and anxiety, may become important treatment targets as strategies are developed for translating cognitive enhancement to real-world functional performance.

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Crossref · 10.1016/j.psc.2005.05.004

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Authors
Bowie, C. R., & Harvey, P. D.
Affiliations
Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Bowie, Christopher R.
Venue
Psychiatric Clinics of North America
Publisher
Elsevier BV
Published
2005-09
Volume
28
Issue
3
Pages
613-633
ISSN
0193-953X (ISSN-L)
OpenAlex
W1997505223
Cited by
280
References
160
Citations by year
2026: 5 · 2025: 6 · 2024: 13 · 2023: 8 · 2022: 4 · 2021: 10 · 2020: 10 · 2019: 12 · 2018: 11 · 2017: 12 · 2016: 10 · 2015: 13 · 2014: 17 · 2013: 17 · 2012: 12
FWCI
3.37
Type
journal article
Language
en
Open access
closed
Locations
  • Psychiatric Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (MH-63116, R01MH063116)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
schizophrenia, cognitive impairment, neurocognitive impairment, attention, working memory, executive function, verbal learning and memory, language skills, negative symptoms, social functioning, adaptive behavior, depression, anxiety, cognitive enhancement, functional outcome
MeSH terms
Attention, Cognition Disorders, Humans, Language Disorders, Memory Disorders, Neuropsychological Tests, Schizophrenia, Social Perception, Antipsychotic Agents, Verbal Learning, Substance-Related Disorders

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