Cited by 378Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesDementia and Cognitive Impairment Research

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The role of cognitive impairment in general functioning in major depression

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Baune, Bernhard T., Miller, Robyn, McAfoose, Jordan, Johnson, Melissa, Quirk, Frances, Mitchell, David·2010·Psychiatry Research

DOI 10.1016/j.psychres.2008.12.001

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Abstract

The association between cognitive performance and general functioning in depression is controversial. The present study evaluated the association between cognitive dysfunction and major depressive disorder (MDD, N=70) as compared with age- and gender-matched healthy controls (n=206) and its relationship to general functioning (physical and mental health quality of life, activities of daily living, and employment status) in participants with current MDD (n=26) and those with previous MDD only (n=44). Participants were assessed clinically using the Mini International Neuropsychiatric Interview (M.I.N.I.) for the depression groups and the Diagnostic Interview for Psychoses (DIP-DM) for the control group. Measures to evaluate cognition and quality of lifes comprised the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), the Short Form-36 Health Survey Questionnaire, and the Activities/Instrumental Activities of Daily Living (ADL/IADL); employment status was also assessed in MDD. The results showed that a) while individuals with current depression had worse cognitive performance in all domains than healthy controls, those individuals with previous depression had lasting cognitive impairments in the domains of immediate memory and attention as compared with healthy controls; b) individuals with current depression had lower scores in the visuospatial/constructional and attention domains and the total score than individuals with previous depression; c) individuals in the depression group as a whole who were currently unemployed had significantly lower scores in all domains (except attention) of cognitive function; d) cognitive function was not related to either physical or mental quality of life or impairments of activities of daily living (ADL, IADL); e) that unemployment in previous depression was related to poor cognitive function similar to those with current depression. The results indicate that MDD may have detrimental and lasting effects on cognitive performance partly related to poorer general functioning.

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Authors: Baune, B. T., Miller, R., McAfoose, J., Johnson, M., Quirk, F., & Mitchell, D.
Affiliations: James Cook University (AU)
The University of Sydney (AU)
Corresponding author: Baune, Bernhard T.
ORCID: Baune, Bernhard T.
Quirk, Frances
Venue: Psychiatry Research
Publisher: Elsevier BV
Published: 2010-04
Volume: 176
Issue: 2-3
Pages: 183-189
ISSN: 0165-1781 (ISSN-L)
DOI: 10.1016/j.psychres.2008.12.001
OpenAlex: W2127641012
Cited by: 378
References: 52
Citations by year: 2026: 7 · 2025: 24 · 2024: 21 · 2023: 17 · 2022: 23 · 2021: 26 · 2020: 35 · 2019: 28 · 2018: 27 · 2017: 29 · 2016: 33 · 2015: 33 · 2014: 24 · 2013: 18 · 2012: 14
FWCI: 11.97
Type: journal article
Language: en
Open access: green
figshare.com
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Psychiatry Research (publishedVersion)
PubMed (publishedVersion)
ResearchOnline - JCU (James Cook University) (submittedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Figshare (submittedVersion, cc-by)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Funders: James Cook University
U.S. Public Health Service (R01AAA01272508)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: major depressive disorder, cognitive impairment, general functioning, unemployment, activities of daily living, quality of life, attention, memory, visuospatial ability, neuropsychological performance
MeSH terms: Activities of Daily Living, Adult, Aged, Analysis of Variance, Attention, Cognition Disorders, Major Depressive Disorder, Employment, Female, Health Surveys, Humans, Language, Male, Memory, Middle Aged, Neuropsychological Tests, Quality of Life, Surveys and Questionnaires, Visual Perception, Case-Control Studies

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The role of cognitive impairment in general functioning in major depression

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