Cited by 42Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesSchizophrenia research and treatment

Systematic review of neurocognition and occupational functioning in major depressive disorder

Evans, Vanessa C, Chan, Sarah SL, Iverson, Grant L, Bond, David J, Yatham, Lakshmi N, Lam, Raymond W·2013·Neuropsychiatry

Abstract

Occupational impairment accounts for much of the burden and economic costs associated with major depressive disorder (MDD). Many studies have documented neurocognitive deficits in MDD, and depression-associated cognitive dysfunction would be expected to have significant effects on occupational functioning. We systematically reviewed the literature for studies on neurocognition and occupational functioning in MDD. Electronic databases (e.g., MEDLINE, PsychInfo and Cochrane Clinical Trials) were searched using appropriate terms and bibliographies of relevant publications were scanned for additional citations. Two reviewers independently reviewed papers for inclusion and data extraction, with conflicts resolved by consensus. Inclusion criteria were diagnosis of MDD using validated criteria (e.g., DSM‑IV or ICD‑10), use of objective neuropsychological tests and use of a specific measure of occupational functioning. Of 630 citations identified in the initial search, only two studies met inclusion criteria and were included in a qualitative review. Both had significant methodological limitations. Nonetheless, the depressed samples had significant neurocognitive deficits that were associated with employment status and work impairment. Neurocognitive dysfunction is probably associated with impairment in occupational functioning in individuals with MDD, but the evidence is limited. Further research should examine specific cognitive domains, and use validated measures of work functioning and productivity.

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Crossref · 10.2217/npy.13.3

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Authors
Evans, V. C., Chan, S. S., Iverson, G. L., Bond, D. J., Yatham, L. N., & Lam, R. W.
Affiliations
University of British Columbia (CA)
Venue
Neuropsychiatry
Published
2013-02
Volume
3
Issue
1
Pages
97-105
ISSN
1758-2008 (ISSN-L)
OpenAlex
W2120329374
Cited by
42
References
56
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 2 · 2013: 1
FWCI
0.67
Type
journal article
Language
en
Open access
closed
Locations
Neuropsychiatry (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
major depressive disorder, neurocognitive function, occupational functioning, cognitive impairment, work impairment, employment status, neuropsychological assessment, labor productivity

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