Systematic review of neurocognition and occupational functioning in major depressive disorder
Abstract
Occupational impairment accounts for much of the burden and economic costs associated with major depressive disorder (MDD). Many studies have documented neurocognitive deficits in MDD, and depression-associated cognitive dysfunction would be expected to have significant effects on occupational functioning. We systematically reviewed the literature for studies on neurocognition and occupational functioning in MDD. Electronic databases (e.g., MEDLINE, PsychInfo and Cochrane Clinical Trials) were searched using appropriate terms and bibliographies of relevant publications were scanned for additional citations. Two reviewers independently reviewed papers for inclusion and data extraction, with conflicts resolved by consensus. Inclusion criteria were diagnosis of MDD using validated criteria (e.g., DSMâÂÂIV or ICDâÂÂ10), use of objective neuropsychological tests and use of a specific measure of occupational functioning. Of 630 citations identified in the initial search, only two studies met inclusion criteria and were included in a qualitative review. Both had significant methodological limitations. Nonetheless, the depressed samples had significant neurocognitive deficits that were associated with employment status and work impairment. Neurocognitive dysfunction is probably associated with impairment in occupational functioning in individuals with MDD, but the evidence is limited. Further research should examine specific cognitive domains, and use validated measures of work functioning and productivity.
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Cognitive symptoms have been associated with poor occupational functioning and unemployment, work-related disability, and adverse psychosocial outcomes.
“Cognitive symptoms have also been associated with poor occupational functioning [18] and unemployment [19], work-related disability, and adverse psychosocial outcomes [20-22].”
From Wearable technology for high-frequency cognitive and mood assessment in major depressive disorder: longitudinal observational study (2019) · cites this paper as [20]
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- Authors
- Evans, V. C., Chan, S. S., Iverson, G. L., Bond, D. J., Yatham, L. N., & Lam, R. W.
- Affiliations
- University of British Columbia (CA)
- Venue
- Neuropsychiatry
- Publisher
- OMICS Publishing Group
- Published
- 2013-02
- Volume
- 3
- Issue
- 1
- Pages
- 97-105
- ISSN
- 1758-2008 (ISSN-L)
- OpenAlex
- W2120329374
- Cited by
- 42
- References
- 56
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 2 · 2013: 1
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychiatry (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- major depressive disorder, neurocognitive function, occupational functioning, cognitive impairment, work impairment, employment status, neuropsychological assessment, labor productivity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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