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Cited by 58Schizophrenia research and treatmentBipolar Disorder and TreatmentTelomeres, Telomerase, and Senescence

Does telomere length mediate associations between inbreeding and increased risk for bipolar I disorder and schizophrenia?

Mansour, Hader, Chowdari, Kodavali, Fathi, Warda, Elassy, Mai, Ibrahim, Ibtihal, Wood, Joel, Bamne, Mikhil, Tobar, Salwa +11 more·2011·Psychiatry Research
DOI 10.1016/j.psychres.2011.01.010
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Abstract

We have recently found that consanguinity is a risk factor for bipolar I disorder (BP1) and schizophrenia (SZ) in Egypt. Inbreeding has been associated with increased cellular stress and impaired physiological function in plants and animals. Previous studies have reported that telomere length (TL), an index of oxidative stress and cellular senescence is significantly reduced among patients with SZ or mood disorders compared with control individuals. Hence we evaluated TL as a possible mediator of the observed association between consanguinity and BP1/SZ risk. Patients with BP1 (n=108), or SZ (n=60) were compared with screened adult controls in separate experiments. TL was estimated using a quantitative PCR (qPCR) based assay. The inbreeding coefficient/consanguinity rate was estimated in two ways: using 64 DNA polymorphisms ('DNA-based' rate); and from family history data ('self report'). Significant correlation between TL and DNA based inbreeding was not observed overall, though suggestive trends were present among the SZ cases. No significant case-control differences in TL were found after controlling for demographic variables. In conclusion, reduced TL may not explain a significant proportion of observed associations between consanguinity and risk for BP1/SZ.

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  • Mansour et al. (2011) found no significant LTL difference in schizophrenia vs. controls, but LTL was confounded by the extent of inbreeding in the schizophrenia population.

    “Mansour et al. (2011), studying a relatively young, highly inbred population, found no significant LTL difference in schizophrenia vs. controls, but LTL was confounded by the extent of inbreeding in the schizophrenia population, and no data were available regarding comorbid diagnoses, medications or treatment response.”

    From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Mansour et al. (2011)

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Authors
Mansour, H., Chowdari, K., Fathi, W., Elassy, M., Ibrahim, I., Wood, J., Bamne, M., Tobar, S., Yassin, A., Salah, H., Elsayed, H., Eissa, A., El-Boraie, H., Ibrahim, N. E., Elsayed, M., El-Bahaei, W., Gomaa, Z., El-Chennawi, F., & Nimgaonkar, V. L.
Affiliations
  • Mansoura University (EG)
  • University of Pittsburgh (US)
Corresponding author
Nimgaonkar, Vishwajit L.
ORCID
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
2011-06
Volume
188
Issue
1
Pages
129-132
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/j.psychres.2011.01.010
OpenAlex
W2094565632
Cited by
58
References
42
Citations by year
2026: 1 · 2025: 2 · 2022: 7 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 9 · 2015: 9 · 2014: 5 · 2013: 2 · 2012: 1
FWCI
1.97
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Fogarty International Center, National Institute of Health
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Keywords
telomere length, consanguinity, inbreeding, bipolar I disorder, schizophrenia, mediation analysis, inbreeding coefficient, cellular senescence, oxidative stress, Egyptian population
MeSH terms
Adult, Analysis of Variance, Bipolar Disorder, Egypt, Female, Humans, Inbreeding, Male, Risk Factors, Schizophrenia, Linear Models, Case-Control Studies, Telomere, Genetic Predisposition to Disease, Young Adult

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