Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging
Abstract
Background Little is known about the biological mechanisms underlying the excess medical morbidity and mortality associated with mood disorders. Substantial evidence supports abnormalities in stress-related biological systems in depression. Accelerated telomere shortening may reflect stress-related oxidative damage to cells and accelerated aging, and severe psychosocial stress has been linked to telomere shortening. We propose that chronic stress associated with mood disorders may contribute to excess vulnerability for diseases of aging such as cardiovascular disease and possibly some cancers through accelerated organismal aging.Methods Telomere length was measured by Southern Analysis in 44 individuals with chronic mood disorders and 44 nonpsychiatrically ill age-matched control subjects.Results Telomere length was significantly shorter in those with mood disorders, representing as much as 10 years of accelerated aging.Conclusions These results provide preliminary evidence that mood disorders are associated with accelerated aging and may suggest a novel mechanism for mood disorder-associated morbidity and mortality.
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In the MDD group alone in Simon et al. (2006), mean LTL was 770 bp shorter than in healthy controls.
“In the MDD group alone, mean LTL was 770 bp shorter than in healthy controls.”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Simon et al., 2006
According to Simon et al.'s calculations, the 660 bp difference represents approximately 10 years of accelerated cellular aging in the combined mood disorder group.
“According to the authors’ calculations, this represents a very large effect, representing approximately 10 years of accelerated cellular aging in the combined mood disorder group.”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Simon et al., 2006
In Simon et al. (2006), the mean LTL of the entire mood disorder group was 660 base pairs shorter than in healthy controls.
“The mean LTL of the entire mood disorder group was 660 base pairs (bp) shorter than in healthy controls.”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Simon et al., 2006
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The interaction between stressful life events and leukocyte telomere length is associated with PTSD
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“A significant difference in mTL (measured by Southern blot) was also reported in a lymphocyte study of 44 combined mood disorders (15 MD and 15 BD with anxiety and 14 BD without anxiety) and 44 controls (p-value = 0.002) ( Simon et al. 2006 ).”
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Inflammation Through a Psychoneuroimmunological Lens
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- Authors
- Simon, N. M., Smoller, J. W., McNamara, K. L., Maser, R. S., Zalta, A. K., Pollack, M. H., Nierenberg, A. A., Fava, M., & Wong, K.-K.
- Affiliations
- Harvard University (US)
- Dana-Farber Cancer Institute (US)
- Corresponding author
- Simon, Naomi M.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 60
- Issue
- 5
- Pages
- 432-435
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2027686080
- Cited by
- 516
- References
- 27
- Citations by year
- 2026: 2 · 2025: 16 · 2024: 10 · 2023: 18 · 2022: 21 · 2021: 18 · 2020: 29 · 2019: 33 · 2018: 20 · 2017: 34 · 2016: 42 · 2015: 38 · 2014: 47 · 2013: 40 · 2012: 43
- FWCI
- 10.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- National Institutes of Health (5k08mh001770-05)
- National Institute on Aging (K08AG2400401)
- National Institute of Mental Health (K-08 MH01770, MH-01831-01)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- telomere shortening, mood disorders, depression, chronic stress, accelerated aging, oxidative stress, telomere length, cardiovascular disease, cancer risk, psychosocial stress
- MeSH terms
- Adult, Aging, Anxiety, Bipolar Disorder, Chronic Disease, Female, Humans, Male, Middle Aged, Models, Genetic, Reference Values, Stress, Psychological, Case-Control Studies, Matched-Pair Analysis, Telomere, Cellular Senescence, Statistics, Nonparametric, Chromosome Breakage, Mood Disorders
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