Cited by 516Telomeres, Telomerase, and SenescenceStress Responses and CortisolGenetics, Aging, and Longevity in Model Organisms

Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging

Simon, Naomi M., Smoller, Jordan W., McNamara, Kate L., Maser, Richard S., Zalta, Alyson K., Pollack, Mark H., Nierenberg, Andrew A., Fava, Maurizio +1 more·2006·Biological Psychiatry

Abstract

Background Little is known about the biological mechanisms underlying the excess medical morbidity and mortality associated with mood disorders. Substantial evidence supports abnormalities in stress-related biological systems in depression. Accelerated telomere shortening may reflect stress-related oxidative damage to cells and accelerated aging, and severe psychosocial stress has been linked to telomere shortening. We propose that chronic stress associated with mood disorders may contribute to excess vulnerability for diseases of aging such as cardiovascular disease and possibly some cancers through accelerated organismal aging.Methods Telomere length was measured by Southern Analysis in 44 individuals with chronic mood disorders and 44 nonpsychiatrically ill age-matched control subjects.Results Telomere length was significantly shorter in those with mood disorders, representing as much as 10 years of accelerated aging.Conclusions These results provide preliminary evidence that mood disorders are associated with accelerated aging and may suggest a novel mechanism for mood disorder-associated morbidity and mortality.

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Crossref · 10.1016/j.biopsych.2006.02.004

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Authors
Simon, N. M., Smoller, J. W., McNamara, K. L., Maser, R. S., Zalta, A. K., Pollack, M. H., Nierenberg, A. A., Fava, M., & Wong, K.-K.
Affiliations
  • Harvard University (US)
  • Dana-Farber Cancer Institute (US)
Corresponding author
Simon, Naomi M.
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2006-09
Volume
60
Issue
5
Pages
432-435
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2027686080
Cited by
516
References
27
Citations by year
2026: 2 · 2025: 16 · 2024: 10 · 2023: 18 · 2022: 21 · 2021: 18 · 2020: 29 · 2019: 33 · 2018: 20 · 2017: 34 · 2016: 42 · 2015: 38 · 2014: 47 · 2013: 40 · 2012: 43
FWCI
10.60
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Funders
  • National Institutes of Health (5k08mh001770-05)
  • National Institute on Aging (K08AG2400401)
  • National Institute of Mental Health (K-08 MH01770, MH-01831-01)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
telomere shortening, mood disorders, depression, chronic stress, accelerated aging, oxidative stress, telomere length, cardiovascular disease, cancer risk, psychosocial stress
MeSH terms
Adult, Aging, Anxiety, Bipolar Disorder, Chronic Disease, Female, Humans, Male, Middle Aged, Models, Genetic, Reference Values, Stress, Psychological, Case-Control Studies, Matched-Pair Analysis, Telomere, Cellular Senescence, Statistics, Nonparametric, Chromosome Breakage, Mood Disorders

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