Effects of antidepressants on P2X7 receptors
Abstract
Antidepressants including paroxetine, fluoxetine and desipramine are commonly used for treating depression. P2×7 receptors are member of the P2X family. Recent studies indicate that these receptors may constitute a novel potential target for the treatment of depression. In the present study, we examined the action of these antidepressants on cloned rat P2×7 receptors that were stably expressed in human embryonic kidney (HEK) 293 cells by using the whole-cell patch-clamp technique, and found that paroxetine at a dose of 10µM could significantly reduce the inward currents evoked by the P2×7 receptors agonist BzATP by pre-incubation for 6-12 but not by acute application (10µM) or pre-incubation for 2-6h at a dose of 1µM, 3µM or 10µM paroxetine. Neither fluoxetine nor desipramine had significant effects on currents evoked by BzATP either applied acutely or by pre-incubation at various concentrations. These results suggest that the sensitivity of rat P2×7 receptors to antidepressants is different, which may represent an unknown mechanism by which these drugs exert their therapeutic effects and side effects.
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The activity of P2X7R can be selectively modulated by different antidepressant drugs.
“These results suggest that the activity of the P2X7R can be selectively modulated by different antidepressants drugs, pointing to unknown mechanisms by which these drugs may exert their therapeutic and/or side effects.”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [78]
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The P2X7 Receptor: Central Hub of Brain Diseases
Andrejew, R., Oliveira-Giacomelli, Á., Ribeiro, D. E., Glaser, T., Arnaud-Sampaio, V. F., Lameu, C., & Ulrich, H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00124 · Cited by 162 · see citing works
P2X7 Receptor Signaling in Stress and Depression
Ribeiro, D. E., Roncalho, A. L., Glaser, T., Ulrich, H., Wegener, G., & Joca, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112778 · Cited by 129 · see citing works
- Authors
- Wang, W., Xiang, Z.-H., Jiang, C.-L., Liu, W.-Z., & Shang, Z.-L.
- Affiliations
- Second Military Medical University (CN)
- Corresponding author
- Wang, Wei
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 242
- Pages
- 281-287
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2415321706
- Cited by
- 15
- References
- 42
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 4 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 2
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81401126)
- Second Military Medical University (81571169, 2013QN05)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- P2X7 receptor, antidepressants, paroxetine, fluoxetine, desipramine, depression, BzATP, inward current, receptor desensitization, mechanism of action
- MeSH terms
- Adenosine Triphosphate, Animals, Antidepressive Agents, Depressive Disorder, Desipramine, Dose-Response Relationship, Drug, Fluoxetine, Humans, Platelet Aggregation Inhibitors, Paroxetine, Patch-Clamp Techniques, Rats, HEK293 Cells, Receptors, Purinergic P2X7
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