Association between depression and the Gln460Arg polymorphism of P2RX7 gene: A dimensional approach
Abstract
The P2RX7 gene (coding for P2X7 purinergic receptor) has been suggested as a novel candidate gene for major depressive disorder (MDD) and bipolar disorder (BPD). The proposed risk allele (G-allele) of the rs2230912 polymorphism results in an amino acid change at the 460th position, marking this genetic variation a possibly functional one. Here we present a case-control analysis of 171 patients diagnosed with MDD or BPD and 178 controls, as well as a dimensional approach using the Hospital Anxiety and Depression Scale (HADS) for studying the Gln460Arg polymorphism of the P2RX7 gene as a genetic risk factor in depression. While case-control analysis did not show significant difference between the groups, a significant association was found between the P2RX7 polymorphism and the HADS scales in the clinical group (MANOVA P = 0.001). Both anxiety and depression scores increased as the number of G-allele increased in the genotype groups (ANOVA for HADS-anxiety: P = 0.01, HADS-depression: P < 0.001). A significant interaction of clinical status and the P2RX7 polymorphism was also found for the depression scale (MANOVA P = 0.025, subsequent ANOVA for anxiety: P = 0.252; depression: P = 0.002). Whereas patients with G-allele-present genotypes showed more elevated depression scores, level of depression in the control group was not affected by the P2RX7 genotype. In conclusion, case-control analysis did not reveal significant results, but using a symptom severity scale we could support the association between depressive disorder and the G-allele of the Gln460Arg polymorphism in the P2RX7 gene.
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In a case-control study, no difference in the presence of SNP rs2230912 between patients suffering from MDD and controls was shown.
“Subsequent studies, however, have shown controversial results on this polymorphism, and in a case-control study no difference in the presence of SNP rs2230912 between patients suffering from MDD and controls was shown, although it was found that the severity of symptoms of depression was directly related to the presence of the polymorphism [72].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [72]
The severity of symptoms of depression is directly related to the presence of the rs2230912 polymorphism.
“although it was found that the severity of symptoms of depression was directly related to the presence of the polymorphism [72].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [72]
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- Authors
- Hejjas, K., Szekely, A., Domotor, E., Halmai, Z., Balogh, G., Schilling, B., Sarosi, A., Faludi, G., Sasvari‐Szekely, M., & Nemoda, Z.
- Affiliations
- Eötvös Loránd University (HU)
- Semmelweis University (HU)
- Venue
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2008-06-09
- Volume
- 150B
- Issue
- 2
- Pages
- 295-299
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- OpenAlex
- W2084501633
- Cited by
- 100
- References
- 24
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 8 · 2021: 4 · 2020: 1 · 2019: 11 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 7 · 2012: 8
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Magyar Tudományos Akadémia
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- major depressive disorder, bipolar disorder, depression, anxiety, genetic risk factors, purinergic receptors, symptom severity, dimensional approach
- MeSH terms
- Adult, Aged, Alleles, Anxiety, Depression, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Case-Control Studies, Receptors, Purinergic P2, Young Adult, Receptors, Purinergic P2X7
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