Exposure of mother rats to chronic unpredictable stress before pregnancy alters the metabolism of gamma-aminobutyric acid and glutamate in the right hippocampus of offspring in early adolescence in a sexually dimorphic manner
Abstract
There is increasing evidence that mothers' exposure to stress before or during pregnancy is linked to an incidence of psychiatric disorders in offspring. However, a few studies have estimated the role of sex in the detrimental effects of pre-gestational stress on the offspring rats at early adolescence. Sex differences regarding the metabolism of gamma-aminobutyric acid and glutamate in the right hippocampus were investigated by MRS when the offspring rats reached 30 days. Additionally, the impact of pre-gestational stress exposed on an additional short-term acute stressor, such as forced swim, was examined in the male and female offspring rats. Our findings showed female offspring rats were more vulnerable to stressful conditions for either pre-gestational stress or acute stress in early adolescence, and had decreased GABA/Cr+PCr and Glu/Cr+PCr in the right hippocampus. Interestingly, in response to forced swim, male offspring rats whose mothers were exposed to pre-gestational stress were more affected by the short-term acute stressor and this was manifested by change of Glu/GABA and Glu/Gln in the right hippocampus. These data indicated that although female offspring rats were more vulnerable to pre-gestational stress from their mothers than males, in response to an additional acute stressor they showed better response. Therefore, both sexually dimorphic manner and combination of stressful procedures should be carefully considered in the study of stress-related psychiatric disorders in early adolescence.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Pre-gestational stress-exposed rat offspring show altered neurotransmitter metabolism of gamma-aminobutyric acid and glutamate in the right hippocampus.
“and altered neurotransmitter metabolism of gamma-aminobutyric acid and glutamate in the right hippocampus of pre-gestational stress-exposed rat offspring [100].”
From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [100]
Cites
Creatine and Creatinine Metabolism
Wyss, M., & Kaddurah-Daouk, R. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1107 · Cited by 2,950 · see citing works
Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832 · see citing works
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586 · see citing works
Chronic mild stress-induced anhedonia: A realistic animal model of depression
Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160 · cited 1× · see citing works
“The SIT is an additional, objective indicator to evaluate the rewarding value of sucrose solution in rodent chronic stress models (Willner et al., 1992).”
Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity.
Sibson, N. R., Dhankhar, A., Mason, G. F., Rothman, D. L., Behar, K. L., & Shulman, R. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.316 · Cited by 897 · see citing works
Postsynaptic signaling and plasticity mechanisms
Sheng, M., & Kim, M. J. (2002) · Science · doi:10.1126/science.1075333 · Cited by 731 · see citing works
Limbic Regulation of Hypothalamo‐Pituitary‐Adrenocortical Function during Acute and Chronic Stress
Jankord, R., & Herman, J. P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.012 · Cited by 578 · see citing works
Prenatal stress and brain development
Charil, A., Laplante, D. P., Vaillancourt, C., & King, S. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.06.002 · Cited by 554 · see citing works
Cunningham, M. G., Bhattacharyya, S., & Benes, F. M. (2002) · Journal of Comparative Neurology · doi:10.1002/cne.10376 · Cited by 474 · see citing works
Physiological stress reactivity in human pregnancy—a review
de Weerth, C., & Buitelaar, J. K. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.10.005 · Cited by 399 · see citing works
Chronic mild stress impact: Are females more vulnerable?
Dalla, C., Antoniou, K., Drossopoulou, G., Xagoraris, M., Kokras, N., Sfikakis, A., & Papadopoulou‐Daifoti, Z. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.068 · Cited by 340 · see citing works
Huang, G. Z., & Woolley, C. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.035 · Cited by 288 · see citing works
Role of GABA and Glutamate Circuitry in Hypothalamo‐Pituitary‐Adrenocortical Stress Integration
HERMAN, J. P., MUELLER, N. K., & FIGUEIREDO, H. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.004 · Cited by 282 · see citing works
Naninck, E. F. G., Hoeijmakers, L., Kakava-Georgiadou, N., Meesters, A., Lazic, S. E., Lucassen, P. J., & Kőrösi, A. (2014) · Hippocampus · doi:10.1002/hipo.22374 · Cited by 281 · see citing works
Local circuit regulation of paraventricular nucleus stress integration
Herman, J. P., Tasker, J. G., Ziegler, D. R., & Cullinan, W. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00681-5 · Cited by 274 · see citing works
Radley, J. J., Gosselink, K. L., & Sawchenko, P. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5924-08.2009 · Cited by 268 · see citing works
Prenatal exposure to maternal psychosocial stress and HPA axis regulation in young adults
Entringer, S., Kumsta, R., Hellhammer, D. H., Wadhwa, P. D., & Wüst, S. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.11.006 · Cited by 251 · see citing works
A common substrate for prefrontal and hippocampal inhibition of the neuroendocrine stress response
Radley, J. J., & Sawchenko, P. E. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6040-10.2011 · Cited by 251 · see citing works
Rhodes, M. E., & Rubín, R. T. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00011-9 · Cited by 215 · see citing works
Dynamic Regulation of Synaptic GABA Release by the Glutamate-Glutamine Cycle in Hippocampal Area CA1
Liang, S., Carlson, G. C., & Coulter, D. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0329-06.2006 · Cited by 203 · see citing works
Prenatal stress and neonatal rat brain development
van den Hove, D., Steinbusch, H. W. M., Scheepens, A., van de Berg, W. D. J., Kooiman, L. A. M., Boosten, B. J. G., Prickaerts, J., & Blanco, C. E. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.060 · Cited by 192 · see citing works
Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus
Tabatadze, N., Huang, G., May, R. M., Jain, A., & Woolley, C. S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1067-15.2015 · Cited by 191 · see citing works
Role of the paraventricular nucleus microenvironment in stress integration
Herman, J. P., Cullinan, W. E., Ziegler, D. R., & Tasker, J. G. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02133.x · Cited by 168 · see citing works
McCormick, C. M., Linkroum, W., Sallinen, B. J., & Miller, N. W. (2002) · Stress · doi:10.1080/1025389021000061165 · Cited by 151 · see citing works
Jackson, J. G., O’Donnell, J. C., Takano, H., Coulter, D. A., & Robinson, M. B. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3510-13.2014 · Cited by 146 · see citing works
Northoff, G., & Sibille, E. L. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.68 · Cited by 145 · see citing works
Fujioka, T., Sakata, Y., Yamaguchi, K., Shibasaki, T., Kato, H., & Nakamura, S. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00073-1 · Cited by 134 · see citing works
Knox, D., Perrine, S. A., George, S. A., Galloway, M. P., & Liberzon, I. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.05.052 · Cited by 132 · see citing works
Peng, L., Hertz, L., Huang, R., Sonnewald, U., Petersen, S. B., Westergaard, N., Larsson, O. M., & Schousboe, A. (1994) · Developmental Neuroscience · doi:10.1159/000111357 · Cited by 128 · see citing works
Stress during Adolescence Increases Novelty Seeking and Risk-Taking Behavior in Male and Female Rats
Toledo-Rodriguez, M., & Sandi, C. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00017 · Cited by 126 · see citing works
Di, S., Itoga, C. A., Fisher, M. O., Solomonow, J., Roltsch, E. A., Gilpin, N. W., & Tasker, J. G. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2279-15.2016 · Cited by 120 · see citing works
Almeida-Suhett, C. P., Prager, E. M., Pidoplichko, V. I., Figueiredo, T. H., Marini, A. M., Li, Z., Eiden, L. E., & Braga, M. F. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102627 · Cited by 117 · see citing works
Grønli, J., Fiske, E., Murison, R. C. C., Bjorvatn, B., Sørensen, E., Ursin, R., & Portas, C. M. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.03.018 · Cited by 115 · see citing works
Sex Differences in the Serotonergic Influence on the Hypothalamic-Pituitary-Adrenal Stress Axis
Goel, N., & Bale, T. L. (2010) · Endocrinology · doi:10.1210/en.2009-1180 · Cited by 113 · see citing works
Kapoor, A., Kostaki, A., Janus, C., & Matthews, S. G. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.08.018 · Cited by 109 · see citing works
Pezze, M. A., McGarrity, S., Mason, R., Fone, K. C. F., & Bast, T. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3450-13.2014 · Cited by 106 · see citing works
Shao, Y., Yan, G., Xuan, Y., Peng, H., Huang, Q., Wu, R., & Xu, H. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.01.005 · Cited by 87 · see citing works
Self-citationReduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress
Suárez-Roca, H., Leal, L., Silva, J. A., Piñerúa-Shuhaibar, L., & Quintero, L. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.12.022 · Cited by 79 · see citing works
Glutamate, a neurotransmitter—And so much more
Hertz, L. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.021 · Cited by 78 · see citing works
Glutamate–glutamine cycle and exchange in the placenta–fetus unit during late pregnancy
Wu, X., Xie, C., Zhang, Y., Fan, Z., Yin, Y., & Blachier, F. (2014) · Amino Acids · doi:10.1007/s00726-014-1861-5 · Cited by 77 · see citing works
Huang, Y., Shi, X., Xu, H., Yang, H., Tian, C., Chen, S., & Chen, X. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0152-0 · Cited by 68 · see citing works
Self-citationMairesse, J., Gatta, E., Reynaert, M., Marrocco, J., Morley‐Fletcher, S., Soichot, M., Deruyter, L., Camp, G. V., Bouwalerh, H., Fagioli, F., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.07.005 · Cited by 63 · see citing works
Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function
Raudensky, J., & Yamamoto, B. K. (2007) · Brain Research · doi:10.1016/j.brainres.2006.12.002 · Cited by 63 · see citing works
(1996) · PubMed · Cited by 61 · see citing works
Dopaminergic involvement in attention a novel animal model
Katz, R. J., & Schmaltz, K. (1981) · Progress in Neuro-Psychopharmacology · doi:10.1016/0364-7722(81)90099-0 · Cited by 59 · see citing works
Corticosterone Peak is Responsible for Stress-Induced Elevation of Glutamate in the Hippocampus
Ábrahám, I. M., Juhász, G. D., Kékesi, K. A., & Kovács, K. (1998) · Stress · doi:10.3109/10253899809167281 · Cited by 59 · see citing works
Hasler, G., van der Veen, J. W., Geraci, M., Shen, J., Pine, D., & Drevets, W. C. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.023 · Cited by 58 · see citing works
Huang, Y., Xu, H., Li, H., Yang, H., Chen, Y., & Shi, X. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-22 · Cited by 55 · see citing works
Self-citationHippocampal biomarkers of fear memory in an animal model of generalized anxiety disorder
Dias, G. P., Bevilaqua, M. C. D. N., da Luz, A. C. D. D. S., Fleming, R. L., de Carvalho, L. A., Cocks, G. D., Beckman, D., Hosken, L., Machado, W. D. S., Corrêa-e-Castro, A. C., et al. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.01.012 · Cited by 55 · see citing works
Zhu, M., Wang, W., Huang, J., Feng, Y., Regunathan, S., & Bissette, G. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.09.001 · Cited by 48 · see citing works
Reznikov, L. R., Reagan, L. P., & Fadel, J. R. (2008) · Brain Research · doi:10.1016/j.brainres.2008.12.022 · Cited by 43 · see citing works
Stan, A. D., Schirda, C., Bertocci, M. A., Bebko, G. M., Kronhaus, D. M., Aslam, H. A., LaBarbara, E. J., Tanase, C., Lockovich, J., Pollock, M., et al. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.05.016 · Cited by 41 · see citing works
Li, H., Zhang, L., Fang, Z., Lin, L., Wu, C., & Huang, Q. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.12.017 · Cited by 40 · see citing works
Self-citationKanamori, K., Ross, B. D., & Kuo, E. L. (1995) · Biochemical Journal · doi:10.1042/bj3110681 · Cited by 38 · see citing works
Li, J.-T., Zhao, Y., Wang, H.-L., Wang, X.-D., Su, Y., & Si, T. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.003 · Cited by 37 · see citing works
Koch, H. R., McCormack, K. M., Sánchez, M. M., & Dario Maestripieri, A. (2012) · Developmental Psychobiology · doi:10.1002/dev.21093 · Cited by 37 · see citing works
Bingham, B., Myung, C., Innala, L., Gray, M. E., Anonuevo, A. M. S., & Viau, V. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.27 · Cited by 31 · see citing works
Das, S. C., Althobaiti, Y. S., Alshehri, F. S., & Sari, Y. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.01.052 · Cited by 31 · see citing works
Baquedano, E., García‐Cáceres, C., Diz-Chaves, Y., Lagunas, N., Calmarza-Font, I., Azcoitia, Í., García‐Segura, L. M., Argente, J., Chowen, J. A., & Frago, L. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027549 · Cited by 28 · see citing works
Kuipers, S. D., Trentani, A., van der Zee, E. A., & den Boer, J. A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.018 · Cited by 27 · see citing works
del Cerro, M. C. R., Ortega, E., Gómez-Oliver, F., Segovia, S., & Pérez-Laso, C. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.07.004 · Cited by 25 · see citing works
Melon, C., Chassain, C., Biélicki, G., Renou, J., Goff, L. K., Salin, P., & Durif, F. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.13015 · Cited by 23 · see citing works
Huang, Y., Chen, S., Xu, H., Yu, X., Lai, H., Ho, G., Huang, Q., & Shi, X. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-67 · Cited by 21 · see citing works
Self-citationOptogenetic fMRI in the mouse hippocampus: Hemodynamic response to brief glutamatergic stimuli
Lebhardt, P., von Hohenberg, C. C., Weber‐Fahr, W., Kelsch, W., & Sartorius, A. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15606455 · Cited by 15 · see citing works
Uzturk, B. G., Jin, S., Rubin, B. S., Bartolome, C. L., & Feig, L. A. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0304 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Wu, Y., Lu, Y.-C., Jacobs, M., Pradhan, S., Kapse, K., Zhao, L., Niforatos-Andescavage, N., Vezina, G., du Plessis, A. J., & Limperopoulos, C. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.19940 · Cited by 218 · see citing works
Wu, Y., De Asis-Cruz, J., & Limperopoulos, C. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02449-0 · Cited by 124 · see citing works
“…in N-acetylaspartate (a marker of neuronal integrity) in the frontal cortex and hypothalamus in early-life stress-exposed mice [97 – 99] and altered neurotransmitter metabolism of gamma-aminobutyric acid and glutamate in the right hippocampus of pre-gestational stress-exposed rat offspring [100].”
BackgroundMcIntosh, A. L., Gormley, S., Tozzi, L., Frodl, T., & Harkin, A. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00150 · Cited by 21 · see citing works
Huang, S., Dong, W., Jiao, Z., Liu, J., Li, K., Wang, H., & Xu, D. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz163 · Cited by 21 · see citing works
Bögi, E., Belovičová, K., Moravčíková, L., Csatlósová, K., Dremencov, E., Lacinová, Ľ., & Dubovický, M. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112131 · Cited by 16 · see citing works
Pavlova, I., & Kučerová, J. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110808 · Cited by 15 · see citing works
Sekar, S., Grandjean, J., Garnell, J. F., Willems, R., Duytschaever, H., Seramani, S., Huang, S., Donck, L. V., & Bhakoo, K. K. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.021 · Cited by 11 · see citing works
Rice, R. C., Gil, D. V., Baratta, A. M., Frawley, R. R., Hill, S. Y., Farris, S. P., & Homanics, G. E. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100603 · Cited by 13 · see citing works
Belovičová, K., Šimončičová, E., Viñas-Noguera, M., Dubovický, M., & Bögi, E. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112944 · Cited by 10 · see citing works
Huang, Y., Hu, L., Li, H., Huang, Y., Li, Y., Yang, J., Gu, J., & Xu, H. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.112497 · Cited by 10 · see citing works
Self-citationSex differences in the vulnerability of the hippocampus to prenatal stress
Soti, M., Ranjbar, H., Kohlmeier, K. A., & Shabani, M. (2022) · Developmental Psychobiology · doi:10.1002/dev.22305 · Cited by 10 · see citing works
Xu, Y., Wang, X., Wang, M.-J., Liu, Y.-Y., Xue, Z., & Chen, J. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111204 · Cited by 6 · see citing works
Mentzinger, J., Teixeira, G. F., Monnerat, J. A. D. S., Velasco, L. L., Lucchetti, B. B., Martins, M., Costa, V., de Andrade, G. P., Magliano, D. C., Rocha, H. N. M., et al. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00243.2024 · Cited by 5 · see citing works
Bögi, E., Belovičová, K., Csatlósová, K., & Dubovický, M. (2017) · Interdisciplinary Toxicology · doi:10.1515/intox-2017-0005 · Cited by 5 · see citing works
Sajdel, E. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817933-8.00007-4 · Cited by 4 · see citing works
Hoppanová, L., Filipova, A., Bukatová, S., Ondáčová, K., Tomko, M., Jurkovičová-Tarabová, B., Dubovický, M., Dremencov, E., & Lacinová, Ľ. (2025) · Scientia Pharmaceutica · doi:10.3390/scipharm93020017 · Cited by 4 · see citing works
Dory, E. K., Loterstein, Y., Hazani, R., Zalsman, G., & Weller, A. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106114 · Cited by 1 · see citing works
Gáspárová, Z., Bukatová, S., & Dubovický, M. (2025) · Drug Research · doi:10.1055/a-2682-5112 · Cited by 1 · see citing works
Impact of gestational stress on bone and body composition in Wistar rats after lactation
Martins, M., Monnerat, J. A. D. S., Teixeira, G. F., Lucchetti, B. B., Mentzinger, J., Velasco, L. L., Sodré, F. A., da Silva, E. M., Rocha, H. N. M., da Nóbrega, A. C. L., et al. (2025) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2025e14551 · Cited by 1 · see citing works
(2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811351-6.00026-7
(2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23565-8.09996-8
Prenatal and Early Postnatal Influences on Health
Anisman, H., Hayley, S. P., & Kusnecov, A. W. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23565-8.00008-9
- Authors
- Huang, Y., Shen, Z., Hu, L., Xia, F., Li, Y., Zhuang, J., Chen, P., & Huang, Q.
- Affiliations
- Shantou University (CN)
- Corresponding author
- Zhuang, Jingwen
- Chen, Peishan
- Huang, Qingjun
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 246
- Pages
- 236-245
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2527788373
- Cited by
- 22
- References
- 65
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 2
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31300927)
- Medical Scientific Research Foundation of Guangdong Province (A2014452)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- maternal stress exposure, chronic unpredictable mild stress, GABA metabolism, glutamate metabolism, hippocampus, early adolescence, forced swim stress, stress-related psychiatric disorders, rat offspring
- MeSH terms
- Animals, Female, gamma-Aminobutyric Acid, Hippocampus, Male, Mothers, Pregnancy, Prenatal Exposure Delayed Effects, Sex Factors, Stress, Psychological, Rats, Sprague-Dawley, Glutamic Acid, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
