The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
The effect of mindfulness meditation training on biological acute stress responses in generalized anxiety disorder
Open accessAbstract
Mindfulness-Based interventions have increased in popularity in psychiatry, but the impact of these treatments on disorder-relevant biomarkers would greatly enhance efficacy and mechanistic evidence. If Generalized Anxiety Disorder (GAD) is successfully treated, relevant biomarkers should change, supporting the impact of treatment and suggesting improved resilience to stress. Seventy adults with GAD were randomized to receive either Mindfulness-Based Stress Reduction (MBSR) or an attention control class; before and after, they underwent the Trier Social Stress Test (TSST). Area-Under-the-Curve (AUC) concentrations were calculated for adrenocorticotropic hormone (ACTH) and pro-inflammatory cytokines. MBSR participants had a significantly greater reduction in ACTH AUC compared to control participants. Similarly, the MBSR group had a greater reduction in inflammatory cytokines' AUC concentrations. We found larger reductions in stress markers for patients with GAD in the MBSR class compared to control; this provides the first combined hormonal and immunological evidence that MBSR may enhance resilience to stress.
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“Hoge et al. (2018) have shown that anxiety reduction is associated with improved emotional resilience and concentration.”
From The influence of teacher-guided mindfulness practice on inter and intra-personal abilities among Israeli Arab students (2024) · cites this paper as Hoge et al., 2018
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“A similarly sized trial of mindfulness-based stress reduction for generalized anxiety disorder did show reductions in TNF-α, although TNF-α was measured in the context of a challenge, the laboratory-based Trier Social Stress Test (TSST). Similar differences were observed for interleukin-6 and adrenocorticotropic hormone (ACTH). This was interpreted as a greater increase in stress resilience, as”
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“Mindfulness was assessed using the Five Facets of Mindfulness Questionnaire (FFMQ), a 39-item self-report measure of an individual’s tendency to be mindful in daily life.25”
From Mindfulness, Anxiety Symptoms, and Quality of Life in Heart Failure. (2020) · cites this paper as [25]
Experimental — accuracy not yet measuredIn the citing paper
“This study builds on previous research that indicates that mindfulness-based interventions delivered in-person can decrease anxiety in individuals with moderate to severe anxiety (eg, generalized anxiety disorder) and decrease physician burnout [20,28,45,46].”
From Physician Anxiety and Burnout: Symptom Correlates and a Prospective Pilot Study of App-Delivered Mindfulness Training (2020) · cites this paper as [45]
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Metadata
- Authors
- Hoge, E. A., Bui, E., Palitz, S. A., Schwarz, N. R., Owens, M. E., Johnston, J. M., Pollack, M. H., & Simon, N. M.
- Affiliations
- Georgetown University Medical Center (US)
- Massachusetts General Hospital (US)
- Boston University (US)
- Rush University Medical Center (US)
- Harvard University (US)
- Corresponding author
- Hoge, Elizabeth A.
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 262
- Pages
- 328-332
- ISSN
- 0165-1781 (ISSN-L)
- PMC
- PMC5526744
- OpenAlex
- W2581630748
- Cited by
- 193
- References
- 38
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 15 · 2023: 28 · 2022: 24 · 2021: 30 · 2020: 27 · 2019: 25 · 2018: 14
- FWCI
- 24.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Foundation for Suicide Prevention
- Harvard University
- Harvard Catalyst
- National Center for Research Resources (UL1RR025758)
- National Center for Complementary and Integrative Health (K23AT004432, L30 AT005427)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- mindfulness meditation, mindfulness-based stress reduction, generalized anxiety disorder, acute stress response, Trier Social Stress Test, ACTH, inflammatory cytokines, stress resilience, biomarkers, neuroendocrine stress response, inflammation
- MeSH terms
- Adaptation, Psychological, Adrenocorticotropic Hormone, Adult, Anxiety Disorders, Arousal, Female, Humans, Male, Middle Aged, Stress, Psychological, Tumor Necrosis Factor-alpha, Interleukin-6, Meditation, Mindfulness
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