Cited by 201Gut microbiota and healthStress Responses and CortisolGastrointestinal motility and disorders

Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial

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Dalile, Boushra, Vervliet, Bram, Bergonzelli, Gabriela, Verbeke, Kristin, Van Oudenhove, Lukas·2020·Neuropsychopharmacology

Abstract

Short-chain fatty acids (SCFAs) are products of microbial fermentation of dietary fiber in the colon and may mediate microbiota-gut-brain communication. However, their role in modulating psychobiological processes that underlie the development of stress- and anxiety-related disorders is not mechanistically studied in humans. In this triple-blind, randomized, placebo-controlled intervention trial, we examine in a parallel group design the effects of 1-week colonic SCFA-mixture delivery in doses equivalent to fermentation of 10 g or 20 g of arabinoxylan oligosaccharides on responses to psychosocial stress and fear tasks in 66 healthy men. We demonstrate that low and high doses of SCFAs significantly attenuate the cortisol response to psychosocial stress compared to placebo. Both doses of SCFAs increase serum SCFA levels and this increase in circulating SCFAs co-varies significantly with the attenuation of the cortisol response to psychosocial stress. Colonic SCFA delivery does not modulate fecal SCFA concentrations, serum brain-derived neurotrophic factor, cortisol awakening response, fear learning and extinction, or subjective mood ratings. These results demonstrate that colon-delivered SCFAs modulate hypothalamic-pituitary-adrenal axis reactivity to psychosocial stress, thereby supporting their hypothesized role in microbiota-gut-brain communication.

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  1. Boets E. Production of short chain fatty acids in the human colon and their impact on health. Doctoral thesis, KU Leuven, 2016.

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Authors
Dalile, B., Vervliet, B., Bergonzelli, G., Verbeke, K., & Van Oudenhove, L.
Affiliations
  • KU Leuven (BE)
  • Nestlé (Switzerland) (CH)
Venue
Neuropsychopharmacology
Published
2020-06-10
Volume
45
Issue
13
Pages
2257-2266
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
OpenAlex
W3033823110
Cited by
201
References
87
Citations by year
2026: 36 · 2025: 46 · 2024: 38 · 2023: 27 · 2022: 28 · 2021: 21 · 2020: 5
FWCI
6.57
Type
journal article
Language
en
Open access
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Lirias (KU Leuven) (submittedVersion, other-oa)
Funders
Fondation Nestlé
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
short-chain fatty acids, arabinoxylan oligosaccharides, psychosocial stress, cortisol response, hypothalamic-pituitary-adrenal axis, dietary fiber fermentation, fear extinction, brain-derived neurotrophic factor, cortisol awakening response, anxiety
MeSH terms
Gastrointestinal Microbiome, Colon, Fatty Acids, Volatile, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Stress, Psychological

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