A genome-wide association study of suicide attempts and suicidal ideation in U.S. military veterans
Open accessAbstract
Death by suicide and suicidal behavior are major concerns among U.S. military veterans; however, no genome-wide association studies (GWAS) studies of suicidal behavior have been conducted among U.S. military veterans to date, despite the elevated rate of suicidal behavior observed within this population. Accordingly, the primary objective of the present research was to conduct the first GWAS of suicide attempts and suicidal ideation in a large and well-characterized sample of U.S. military veterans. The gene most significantly associated (p = 9.28 × 10-7) with suicide attempts was the Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 2 (KCNMB2) gene, which plays a key role in neuronal excitability. In addition, replication analyses provided additional support for the potential role of the ABI Family Member 3 Binding Protein (ABI3BP) gene in the pathogenesis of suicidal behavior, as numerous nominal associations were found between this gene and both suicide attempts and suicidal ideation. Additional work aimed at replicating and extending these findings is needed.
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Candidate-gene-based studies and GWAS have not produced consistent results, with genes of interest frequently failing to pass rigorous reproducibility and significance testing.
“overall, candidate-gene-based studies 44,45 and GWAS 30,40,46-49 have not produced consistent results, with genes of interest frequently failing to pass rigorous reproducibility and significance testing.”
From Suicide and suicide risk (2019) · cites this paper as [49]
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- Authors
- Kimbrel, N. A., Garrett, M. E., Dennis, M. F., Hauser, M. A., Ashley-Koch, A. E., & Beckham, J. C.
- Affiliations
- Duke Medical Center (US)
- Duke University (US)
- Corresponding author
- Kimbrel, Nathan A.
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 269
- Pages
- 64-69
- ISSN
- 0165-1781 (ISSN-L)
- PMC
- PMC6207450
- OpenAlex
- W2883166186
- Cited by
- 52
- References
- 41
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 9 · 2022: 13 · 2021: 6 · 2020: 3 · 2019: 10
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (IK2CX000718, I01BX002577, IK6 BX003777, IK2 RX000908, IK2 RX000703, IK2CX000525)
- National Institutes of Health (1s10od018164-01)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- suicide attempts, suicidal ideation, military veterans, genetic susceptibility, neuronal excitability, replication
- MeSH terms
- Adult, Female, Humans, Male, Middle Aged, Military Personnel, Suicide, Attempted, United States, Genetic Variation, Veterans, Genome-Wide Association Study, Suicidal Ideation
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