Modeling cortisol rhythms in a population-based study
Abstract
The aim of these analyses was to develop and describe easily implementable, yet information rich, approaches for analysis of the temporal profile of cortisol in human populations. A typical waking profile of cortisol in a sample of women aged 15-44 was parameterized by a piecewise linear regression model, implemented as a mixed model to accommodate repeated observations among individuals. The model was extended to distinguish characteristic cortisol profiles of obese women from those of non-obese women. Sharp inflection points for the diurnal profile of cortisol were noted at 30 and 75 min past awakening. Obese women showed a slight tendency to have a less sharply rising and declining response to awakening than non-obese women.
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Sample collection occurred between 2 and 4 pm for all subjects to control for circadian variation in cortisol levels.
“Sample collection occurred between 2 and 4 pm for all subjects to control for circadian variation in cortisol levels (Dorn et al., 2007; Ranjit et al., 2005).”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Ranjit et al., 2005
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Adam, E. K., Quinn, M. E., Tavernier, R., McQuillan, M. T., Dahlke, K. A., & Gilbert, K. E. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.05.018 · Cited by 905 · see citing works
Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome
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Smyth, N., Clow, A., Thorn, L., Hucklebridge, F., & Evans, P. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.12.013 · Cited by 85 · see citing works
- Authors
- Ranjit, N., Young, E. A., Raghunathan, T. E., & Kaplan, G. A.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Ranjit, Nalini
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 30
- Issue
- 7
- Pages
- 615-624
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2146775256
- Cited by
- 92
- References
- 20
- Citations by year
- 2026: 3 · 2024: 3 · 2023: 7 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 5 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 7 · 2012: 9
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- Joyce Foundation
- Charles Stewart Mott Foundation
- National Institutes of Health
- National Institute of Mental Health (MH 01931, K05MH001931)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50-HD38986, R24HD047861, P50HD038986)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- cortisol rhythm, obesity, women, piecewise linear regression, mixed models, repeated measures, inflection point, population-based study
- MeSH terms
- Adolescent, Adult, Algorithms, Circadian Rhythm, Data Interpretation, Statistical, Female, Humans, Hydrocortisone, Middle Aged, Obesity, Population, Regression Analysis, Saliva, Work, Single Parent, Statistics, Nonparametric
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