The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Cortisol circadian rhythms and response to stress in children with autism
Abstract
Background Autism is a severe neurodevelopmental disorder characterized by impairment in communication, social interaction, repetitive behaviors and difficulty adapting to novel experiences. The Hypothalamic-Pituitary-Adrenocortical (HPA) system responds consistently to perceived novel or unfamiliar situations and can serve as an important biomarker of the response to a variety of different stimuli. Previous research has suggested that children with autism may exhibit dysfunction of the HPA system, but it is not clear whether altered neuroendrocrine regulation or altered responsiveness underlies the differences between children with and without autism. In order to provide preliminary data concerning HPA regulation and responsiveness, we compared circadian rhythms and response to a non-social, environmental stressor in children with and without autism.Methods Circadian rhythms of cortisol were estimated in children with (N=12) and without (N=10) autism via analysis of salivary samples collected in the morning, afternoon and evening on 2 consecutive days. HPA responsiveness was assessed by examining the time course of changes in salivary cortisol in response to a mock MRI.Results Both groups showed expected circadian variation with higher cortisol concentration in morning than in the evening samples. The children with autism, but not typical children, showed a more variable circadian rhythm as well as statistically significant elevations in cortisol following exposure to a novel, nonsocial stimulus.Conclusions The results suggest that children with autism process and respond idiosyncratically to novel and threatening events resulting in an exaggerated cortisol response.
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“Psychobiological factors, such as stress, might underlie the poor response to novelty and changes in routine in autism [52].”
From The paradox of cognitive flexibility in autism (2009) · cites this paper as [52]
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The long-term behavioural consequences of prenatal stress
Weinstock, M. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.002 · Cited by 1,098
Psychosis and autism as diametrical disorders of the social brain
Crespi, B. J., & Badcock, C. R. (2008) · Behavioral and Brain Sciences · doi:10.1017/s0140525x08004214 · Cited by 635
Gunnar, M. R., Talge, N. M., & Herrera, A. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.02.010 · Cited by 603
The paradox of cognitive flexibility in autism
Geurts, H. M., Corbett, B., & Solomon, M. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2008.11.006 · Cited by 538
Self-citationThe Intense World Theory – A Unifying Theory of the Neurobiology of Autism
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Metadata
- Authors
- Corbett, B. A., Mendoza, S., Abdullah, M., Wegelin, J. A., & Levine, S.
- Affiliations
- University of California, Davis (US)
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 31
- Issue
- 1
- Pages
- 59-68
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2124859267
- Cited by
- 258
- References
- 35
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 11 · 2023: 5 · 2022: 11 · 2021: 15 · 2020: 18 · 2019: 11 · 2018: 21 · 2017: 10 · 2016: 8 · 2015: 16 · 2014: 20 · 2013: 17 · 2012: 14
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r21mh065672-01)
- University of California, Davis
- National Institute of Mental Health (MH065672)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- autism spectrum disorder, cortisol, circadian rhythm, hypothalamic-pituitary-adrenal axis, stress response, salivary cortisol, children, novel stimuli, neuroendocrine regulation, biomarkers
- MeSH terms
- Autistic Disorder, Child, Circadian Rhythm, Environment, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Surveys and Questionnaires, Saliva, Sensation, Specimen Handling, Stress, Psychological, Feedback, Psychological
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