Olanzapine-induced weight gain in anorexia nervosa: Involvement of leptin and ghrelin secretion?
Abstract
Background Olanzapine (OLA) administration has been reported to induce weight gain in experimental animals and humans, through not yet fully defined mechanisms of action. Aim of this study was to determine whether in patients with Anorexia Nervosa (AN) OLA induces weight gain through the modulation of the hunger-satiety regulatory peptides leptin and ghrelin.Methods Twenty anorexic probands received a 3 months course of cognitive-behavioral psychotherapy and programmed nutritional rehabilitation, combined with OLA PO (2.5 mg for 1 month and 5 mg for 2 months) in ten patients and with placebo PO (PL) in the other 10. Weight, measured as body mass index (BMI), leptin and ghrelin plasma values were monitored before starting the therapy and then monthly for 3 months. Plasma leptin was measured by ELISA, and plasma ghrelin by radioimmunoassay.Results BMI increased significantly but not differently in both treatment groups. Leptin and ghrelin secretion did not change during the course of the treatments. No correlations were observed between BMI values and leptin and ghrelin levels.Conclusions Our data suggest that the weight gain observed in our OLA-treated patients was not linked to drug administration. Moreover, leptin and ghrelin secretions were not responsible for BMI changes.
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A small number of double-blind trials have evaluated the effects of antipsychotics for anorexia nervosa, with essentially non-significant effects.
“A small number of double-blind trials have evaluated the effects of antipsychotics, with essentially non-significant effects [345-347].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [346]
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- Authors
- Brambilla, F., Monteleone, P., & Maj, M.
- Corresponding author
- Brambilla, F.
- Venue
- Psychoneuroendocrinology
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- Elsevier BV
- Published
- 2007-05
- Volume
- 32
- Issue
- 4
- Pages
- 402-406
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2164564819
- Cited by
- 54
- References
- 42
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- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- olanzapine, anorexia nervosa, weight gain, drug-induced weight gain, leptin, ghrelin, body mass index, antipsychotic adverse effects, cognitive behavioral therapy, nutritional rehabilitation
- MeSH terms
- Olanzapine, Adult, Anorexia Nervosa, Benzodiazepines, Double-Blind Method, Female, Humans, Placebos, Weight Gain, Body Mass Index, Selective Serotonin Reuptake Inhibitors, Leptin, Peptide Hormones, Ghrelin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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