Intestinal permeability is decreased in anorexia nervosa
Abstract
Malnutrition and absence of exogenous luminal nutrients in the gastrointestinal tract affect intestinal permeability (IP) leading to an increased penetration of substances that passively cross intestinal epithelium via intercellular pathways. We hypothesised that an increase in IP could occur in patients with anorexia nervosa because of their prolonged fasting and chronic malnutrition. Therefore, we assessed IP in 14 drug-free anorexic women and 19 drug-free age-matched healthy women by means of the lactulose/mannitol (LA/MA) test. To this purpose, after an overnight fast, subjects ingested an oral solution containing 5 g lactulose and 2 g mannitol in 100 ml water. Urine specimens were collected immediately before and 30, 60, 120, 180, 240 and 300 min after the ingestion of the sugar solution. Urinary lactulose and mannitol were determined by high-performance anion exchange chromatography coupled with pulsed amperometric detection. We found that IP, as expressed by the 5-h LA/MA excretion ratio, was significantly decreased in anorexic women because of a lower urinary recovery of lactulose. Moreover, in patients, the time course of lactulose excretion significantly differs from healthy controls. These results do not confirm our hypothesis of increased IP in anorexia nervosa. Since IP reflects the anatomo-functional status of intestinal mucosa, the present findings support the idea that changes in the anatomo-physiology of intestinal mucosa occur in anorexia nervosa.
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Colonic gut permeability data are not available in patients with eating disorders, but a study by Monteleone et al. showed a significant decrease in small intestinal permeability in anorexia nervosa patients.
“Colonic gut permeability data are not available in patients with eating disorders, but a study by Monteleone et al. [103] showed a significant decrease in small intestinal permeability in AN patients.”
A study by Monteleone et al. [103] showed a significant decrease in small intestinal permeability in patients with anorexia nervosa.
“but a study by Monteleone et al. [103] showed a significant decrease in small intestinal permeability in AN patients.”
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- Authors
- Monteleone, P., Carratù, R., Cartenì, M., Generoso, M., Lamberti, M., Magistris, L. D., Brambilla, F., Colurcio, B., Secondulfo, M., & Maj, M.
- Corresponding author
- Monteleone, P
- Venue
- Molecular Psychiatry
- Published
- 2003-12-22
- Volume
- 9
- Issue
- 1
- Pages
- 76-80
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2087170119
- Cited by
- 64
- References
- 27
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 4 · 2023: 8 · 2022: 9 · 2021: 5 · 2020: 4 · 2019: 9 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- anorexia nervosa, intestinal permeability, lactulose/mannitol test, malnutrition, fasting, intestinal mucosa, intercellular transport
- MeSH terms
- Adult, Anorexia Nervosa, Diuretics, Osmotic, Female, Gastrointestinal Agents, Humans, Intestinal Absorption, Lactulose, Mannitol, Malnutrition
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