Randomized Controlled Trial of Olanzapine in the Treatment of Cognitions in Anorexia Nervosa
Abstract
Objective: Recovery from anorexia nervosa is confounded by intrusive anorec-tic cognitions and rituals. It has been observed that olanzapine, an atypical antipsychotic, can reduce this anorexic rumination. A pilot study was designed to test the effectiveness of olanzapine in this role. Methods: A randomized trial of olanzapine versus chlorpromazine, with anorexic rumination as the primary outcome, was conducted. Of the 26 patients who presented, 15 were randomized in a balanced block design, eight to olanzapine and seven to chlorpromazine. Results: Only the olanzapine group had a significant reduction in the degree of rumination. Conclusion: Olanzapine may be of benefit in anorexia nervosa by causing a reduction in anorexic rumination.
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A small number of double-blind trials have evaluated the effects of antipsychotics for anorexia nervosa, with essentially non-significant effects.
“A small number of double-blind trials have evaluated the effects of antipsychotics, with essentially non-significant effects [345-347].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [347]
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- Authors
- Mondraty, N., Laird Birmingham, C., Touyz, S., Sundakov, V., Chapman, L., & Beumont, P.
- Affiliations
- Peter Beumont Eating Disorder Service, Ashfield, NSW, Australia
- Eating Disorders Programme, St Paul's Hospital, University of British, Columbia, Vancouver, Canada
- The University of Sydney (AU)
- Royal Prince Alfred Hospital (AU)
- Corresponding author
- Mondraty, Naresh
- Venue
- Australasian Psychiatry
- Publisher
- SAGE Publications
- Published
- 2005-03
- Volume
- 13
- Issue
- 1
- Pages
- 72-75
- ISSN
- 1039-8562 (ISSN-L)
- 1440-1665
- OpenAlex
- W2055502324
- Cited by
- 130
- References
- 8
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 10 · 2018: 8 · 2017: 1 · 2016: 4 · 2015: 7 · 2014: 7 · 2013: 4 · 2012: 11
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Australasian Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- olanzapine, anorexia nervosa, rumination, chlorpromazine, atypical antipsychotics, eating disorders
- MeSH terms
- Olanzapine, Adult, Anorexia Nervosa, Benzodiazepines, Chlorpromazine, Cognition Disorders, Drug Administration Schedule, Female, Humans, Male, Antipsychotic Agents
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