Motivational systems and the neural circuitry of maternal behavior in the rat
Open accessAbstract
Jay Rosenblatt's approach‐avoidance model of maternal behavior proposes that maternal behavior occurs when the tendency to approach infant stimuli is greater than the tendency to avoid such stimuli. Our research program has uncovered neural circuits which conform to such a model. We present evidence that the medial preoptic area (MPOA: located in the rostral hypothalamus) may regulate maternal responsiveness by depressing antagonistic neural systems which promote withdrawal responses while also activating appetitive neural systems which increase the attractiveness of infant‐related stimuli. These MPOA circuits are activated by the hormonal events of late pregnancy. Preoptic efferents may suppress a central aversion system which includes an amygdala to anterior hypothalamic circuit. Preoptic efferents are also shown to interact with components of the mesolimbic dopamine (DA) system to regulate proactive voluntary maternal responses. We make a distinction between specific (MPOA neurons) and nonspecific motivational systems (mesolimbic DA system) in the regulation of maternal responsiveness. © 2006 Wiley Periodicals, Inc. Dev Psychobiol 49: 12–21, 2007.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There is well-documented evidence for anatomical circuitry underlying specific actions in mammals, such as vocalizations, maternal behavior, freezing, startle, attack, and appetitive behavior.
“There is well-documented evidence for the anatomical circuitry underlying specific actions such as vocalizations (Jürgens 2009), maternal behavior (e.g., pup retrieval, grooming, nest building, and nursing; Numan 2007), freezing (Fanselow & Poulos 2005), startle (Davis et al. 2008; Lang et al. 2000), attack (Blanchard & Blanchard 2003) and appetitive behavior (Berridge & Kringelbach 2008; Shultz 2”
From The brain basis of emotion: a meta-analytic review (2012) · cites this paper as Numan 2007
One role of the mesolimbic dopamine pathway and accumbal dopamine is to generate the powerful motivational states that produce maternal behaviors.
“This suggests that, similar to drugs of abuse, one role of the mesolimbic DA pathway and of accumbal DA in particular is to generate the powerful motivational states that produce such dramatic maternal behaviors (reviewed in Numan 2007; for a comprehensive treatment of the subject, see Numan and Insel 2003).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Numan 2007
In rodents, changes in the neural structure and function during the early postpartum period have been observed consistently to support maternal motivation and to enhance processing of sensory information that is specialized to detect and respond to infants' calls.
“In rodents, changes in the neural structure and function during the early postpartum period have been observed consistently to support maternal motivation and to enhance processing of sensory information that is specialized to detect and respond to infants’ calls (Fleming et al., 2002; Numan, 2007).”
From The maternal brain and its plasticity in humans (2016) · cites this paper as Numan, 2007
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1996) · Cited by 3,692 · see citing works
NEWMAN, S. W. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09271.x · Cited by 1,189 · see citing works
The Neurobiology of Parental Behavior
(2003) · Hormones, Brain, and Behavior · doi:10.1007/b97533 · Cited by 684 · see citing works
Self-citationA Defect in Nurturing in Mice Lacking the Immediate Early Gene fosB
Brown, J. R., Ye, H., Bronson, R. T., Dikkes, P., & Greenberg, M. E. (1996) · Cell · doi:10.1016/s0092-8674(00)80101-4 · Cited by 339 · see citing works
Fleming, A. S., & Luebke, C. (1981) · Physiology & Behavior · doi:10.1016/0031-9384(81)90054-8 · Cited by 305 · see citing works
Lee, A. M., Clancy, S., & Fleming, A. S. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00109-0 · Cited by 301 · see citing works
Amygdaloid inhibition of maternal behavior in the nulliparous female rat☆
FLEMING, A., Vaccarino, F. J., & Luebke, C. (1980) · Physiology & Behavior · doi:10.1016/0031-9384(80)90377-7 · Cited by 271 · see citing works
Fleming, A. S., & Rosenblatt, J. S. (1974) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0035936 · Cited by 247 · see citing works
Hypothalamic Neural Circuits Regulating Maternal Responsiveness Toward Infants
Numan, M. (2006) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582306288790 · Cited by 247 · see citing works
Self-citationVomeronasal and Olfactory System Modulation of Maternal Behavior in the Rat
Fleming, A. S., Vaccarino, F. J., Tambosso, L., & Chee, P. (1979) · Science · doi:10.1126/science.760196 · Cited by 244 · see citing works
Numan, M., & Smith, H. G. (1984) · Behavioral Neuroscience · doi:10.1037//0735-7044.98.4.712 · Cited by 217 · see citing works
Self-citationNeuroanatomical Circuitry for Mammalian Maternal Behaviora
Numan, M., & Sheehan, T. P. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51915.x · Cited by 194 · see citing works
Self-citationNuman, M., & Smith, H. G. (1984) · Behavioral Neuroscience · doi:10.1037/0735-7044.98.4.712 · Cited by 190 · see citing works
Self-citationNuman, M., Numan, M. J., Pliakou, N., Stolzenberg, D. S., Mullins, O. J., Murphy, J. M., & Smith, C. D. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.6.1588 · Cited by 186 · see citing works
Self-citationSomatosensation and Maternal Care in Norway Rats
Stern, J. M. (1996) · Advances in the study of behavior · doi:10.1016/s0065-3454(08)60335-6 · Cited by 181 · see citing works
Sheehan, T. P., Paul, M., Amaral, E., Numan, M. J., & Numan, M. J. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00286-x · Cited by 162 · see citing works
Self-citationStack, E. C., Balakrishnan, R., Numan, M. J., & Numan, M. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00370-9 · Cited by 151 · see citing works
Self-citationNuman, M., & Numan, M. J. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.t01-1-00597.x · Cited by 149 · see citing works
Self-citationSheehan, T. P., Cirrito, J. R., Numan, M. J., & Numan, M. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.2.337 · Cited by 139 · see citing works
Self-citationNuman, M., Numan, M. J., Schwarz, J. M., Neuner, C. M., Flood, T. F., & Smith, C. D. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.08.008 · Cited by 139 · see citing works
Self-citationNuman, M., Numan, M. J., & English, J. B. (1993) · Hormones and Behavior · doi:10.1006/hbeh.1993.1005 · Cited by 135 · see citing works
Self-citationPoling, A. (2016) · The SAGE Encyclopedia of Theory in Psychology · doi:10.4135/9781483346274.n29 · Cited by 120 · see citing works
Lonstein, J. S., & Vries, G. J. D. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00287-6 · Cited by 111 · see citing works
Kinsley, C. H., & Bridges, R. S. (1990) · Developmental Psychobiology · doi:10.1002/dev.420230405 · Cited by 102 · see citing works
Stack, E. C., & Numan, M. (2000) · Behavioral Neuroscience · doi:10.1037//0735-7044.114.3.609 · Cited by 90 · see citing works
Self-citationA developmental and component analysis of active sleep
BLUMBERG, M. S., & Lucas, D. E. (1996) · Developmental Psychobiology · doi:10.1002/(sici)1098-2302(199601)29:1 · Cited by 81 · see citing works
Self-citationStack, E. C., & Numan, M. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.3.609 · Cited by 79 · see citing works
Self-citationA comparative systems model of the regulation of maternal motivation in mammals
Pryce, C. R. (1992) · Animal Behaviour · doi:10.1016/s0003-3472(05)80102-2 · Cited by 71 · see citing works
Flagged first, then by citations
1 of the 29 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Newman, S. W. (1999). The medial extended amygdala in male sexual behavior. Annals of the New York Academy of Sciences, 877, 242-257.
Cited by
Sorted by citations
The brain basis of emotion: a meta-analytic review
Lindquist, K. A., Wager, T. D., Kober, H., Bliss-Moreau, E., & Barrett, L. F. (2012) · Behavioral and Brain Sciences · doi:10.1017/s0140525x11000446 · Cited by 2,320 · see citing works
“…underlying specific actions such as vocalizations (Jürgens 2009), maternal behavior (e.g., pup retrieval, grooming, nest building, and nursing; Numan 2007), freezing (Fanselow & Poulos 2005), startle (Davis et al. 2008; Lang et al. 2000), attack (Blanchard & Blanchard 2003) and appetitive…”
BackgroundLasting epigenetic influence of early-life adversity on the BDNF gene
Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.028 · Cited by 1,273 · see citing works
Dopamine: Functions, Signaling, and Association with Neurological Diseases
Klein, M. O., Battagello, D. S., Cardoso, A. R., Hauser, D. N., Bittencourt, J. C., & Correa, R. G. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0632-3 · Cited by 1,073 · see citing works
The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis
O'Connell, L. A., & Hofmann, H. A. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22735 · Cited by 986 · see citing works
Epigenetic mechanisms and the transgenerational effects of maternal care
Champagne, F. A. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.03.003 · Cited by 812 · see citing works
Emotional Experience in Patients With Schizophrenia Revisited: Meta-analysis of Laboratory Studies
Cohen, A. S., & Minor, K. S. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn061 · Cited by 541 · see citing works
Neural control of maternal and paternal behaviors
Dulac, C., O’Connell, L. A., & Wu, Z. (2014) · Science · doi:10.1126/science.1253291 · Cited by 457 · see citing works
Barrett, J., & Fleming, A. S. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02306.x · Cited by 433 · see citing works
Breastfeeding, brain activation to own infant cry, and maternal sensitivity
Kim, P., Feldman, R., Mayes, L. C., Eicher, V., Thompson, N., Leckman, J. F., & Swain, J. E. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02406.x · Cited by 386 · see citing works
The origins of altruism in offspring care.
Preston, S. D. (2013) · Psychological Bulletin · doi:10.1037/a0031755 · Cited by 368 · see citing works
Numan, M., & Stolzenberg, D. S. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.10.002 · Cited by 361 · see citing works
Self-citationNuman, M., & Young, L. J. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.015 · Cited by 355 · see citing works
Self-citationNeuroendocrine regulation of maternal behavior
Bridges, R. S. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.11.007 · Cited by 346 · see citing works
Burkett, J. P., & Young, L. J. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2794-x · Cited by 307 · see citing works
“…to drugs of abuse , one role of the mesolimbic DA pathway and of accumbal DA in particular is to generate the powerful mo - tivational states that produce such dramatic maternal behav - iors ( reviewed in Numan 2007 ; for a comprehensive treatment of the subject , see Numan and Insel 2003 ) .”
The maternal brain and its plasticity in humans
Kim, P., Strathearn, L., & Swain, J. E. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.08.001 · Cited by 278 · see citing works
Barba‐Müller, E., Craddock, S., Carmona, S., & Hoekzema, E. A. (2018) · Archives of Women s Mental Health · doi:10.1007/s00737-018-0889-z · Cited by 240 · see citing works
Of Mice and Men: Natural Kinds of Emotions in the Mammalian Brain? A Response to Panksepp and Izard
Barrett, L. F., Lindquist, K. A., Bliss‐Moreau, E., Duncan, S., Gendron, M., Mize, J., & Brennan, L. E. (2007) · Perspectives on Psychological Science · doi:10.1111/j.1745-6916.2007.00046.x · Cited by 227 · see citing works
The neural and hormonal bases of human parentalcare
Rilling, J. K. (2013) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.12.017 · Cited by 230 · see citing works
Maternal brain response to own baby‐cry is affected by cesarean section delivery
Swain, J. E., Tasgin, E., Mayes, L. C., Feldman, R., Todd Constable, R., & Leckman, J. F. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01963.x · Cited by 206 · see citing works
Reproductive experience alters hippocampal neurogenesis during the postpartum period in the dam
Pawluski, J. L., & Galea, L. A. M. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.07.031 · Cited by 209 · see citing works
The neurobiology of mammalian parenting and the biosocial context of human caregiving
Feldman, R. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.10.001 · Cited by 209 · see citing works
Oxytocin and mutual communication in mother-infant bonding
Nagasawa, M., Okabe, S., Mogi, K., & Kikusui, T. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00031 · Cited by 202 · see citing works
Responses and functions of dopamine in nucleus accumbens core during social behaviors
Dai, B., Sun, F., Tong, X., Ding, Y., Kuang, A., Osakada, T., Li, Y., & Lin, D. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111246 · Cited by 179 · see citing works
Neural and behavioral responses to attractiveness in adult and infant faces
Hahn, A. C., & Perrett, D. I. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.015 · Cited by 167 · see citing works
Goodson, J. L., & Kingsbury, M. A. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.05.006 · Cited by 156 · see citing works
The role of oxytocin in male and female reproductive behavior
Veening, J. G., A, T. R. D. J., Waldinger, M. D., Korte, S. M., & Olivier, B. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.045 · Cited by 156 · see citing works
Testicular volume is inversely correlated with nurturing-related brain activity in human fathers
Mascaro, J. S., Hackett, P. D., & Rilling, J. K. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305579110 · Cited by 153 · see citing works
Rutherford, H. J. V., Williams, S. K., Moy, S., Mayes, L. C., & Johns, J. M. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00037 · Cited by 140 · see citing works
Endocrine induced changes in brain function during pregnancy
Brunton, P. J., & Russell, J. A. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.062 · Cited by 134 · see citing works
The neurobiology of fatherhood
Rilling, J. K., & Mascaro, J. S. (2017) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2017.02.013 · Cited by 135 · see citing works
Neuroplasticity in the maternal hippocampus: Relation to cognition and effects of repeated stress
Pawluski, J. L., Lambert, K. G., & Kinsley, C. H. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.004 · Cited by 130 · see citing works
Early motherhood in rats is associated with a modification of hippocampal function
Darnaudéry, M., Perez-Martin, M., Del Favero, F., Gomez-Roldan, C., Garcia-Segura, L. M., & Maccari, S. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.05.012 · Cited by 128 · see citing works
Depressive symptoms in early pregnancy disrupt attentional processing of infant emotion
Pearson, R. M., Cooper, R. M., Penton‐Voak, I. S., Lightman, S. L., & Evans, J. (2009) · Psychological Medicine · doi:10.1017/s0033291709990961 · Cited by 128 · see citing works
Mileva‐Seitz, V. R., Steiner, M. S., Atkinson, L. R., Meaney, M. J., Levitan, R. D., Kennedy, J. L., Sokolowski, M. B., & Fleming, A. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061443 · Cited by 127 · see citing works
A, T. R. D. J., Miyetani Chauke, A., Harris, B. N., & Wendy Saltzman, A. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.05.001 · Cited by 123 · see citing works
Moberg, K. U., Handlin, L., & Petersson, M. (2020) · Infant Behavior and Development · doi:10.1016/j.infbeh.2020.101482 · Cited by 125 · see citing works
Oxytocin-messages via the cerebrospinal fluid: Behavioral effects; a review
Veening, J. G., A, T. R. D. J., & Barendregt, H. P. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.05.004 · Cited by 126 · see citing works
Allopregnanolone in the brain: Protecting pregnancy and birth outcomes
Brunton, P. J., Russell, J. A., & Hirst, J. J. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.08.005 · Cited by 122 · see citing works
The maternal brain: an organ with peripartal plasticity
Hillerer, K. M., Jacobs, V. R., Fischer, T., & Aigner, L. (2014) · Neural Plasticity · doi:10.1155/2014/574159 · Cited by 120 · see citing works
Afonso, V. M., King, S., Chatterjee, D., & Fleming, A. S. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.02.003 · Cited by 112 · see citing works
Piallini, G., Palo, F. D., & Simonelli, A. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01625 · Cited by 106 · see citing works
Intranasal oxytocin, but not vasopressin, augments neural responses to toddlers in human fathers
Li, T., Chen, X., Mascaro, J., Haroon, E., & Rilling, J. K. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.01.006 · Cited by 105 · see citing works
Human Maternal Brain Plasticity: Adaptation to Parenting
Kim, P. (2016) · New Directions for Child and Adolescent Development · doi:10.1002/cad.20168 · Cited by 102 · see citing works
Mileva‐Seitz, V. R., Kennedy, J. L., Atkinson, L. R., Steiner, M., Levitan, R. D., Matthews, S. G., Meaney, M. J., Sokolowski, M. B., & Fleming, A. S. (2011) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00671.x · Cited by 100 · see citing works
Flexibility and adaptation of the neural substrate that supports maternal behavior in mammals
Olazábal, D. E., Pereira, M., Agrati, D., Ferreira, A., Fleming, A. S., González-Mariscal, G., Lévy, F., Lucion, A. B., Morrell, J. I., Numan, M., et al. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.004 · Cited by 97 · see citing works
Self-citationDechartres, J., Pawluski, J. L., Guéguen, M., Jablaoui, A., Maguin, E., Rhimi, M., & Charlier, T. D. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12731 · Cited by 97 · see citing works
Carmona, S., Martínez‐García, M., Paternina‐Die, M., Barba‐Müller, E., Wierenga, L. M., Alemán‐Gómez, Y., Pretus, C., Marcos‐Vidal, L., Beumala, L., Cortizo, R., et al. (2019) · Human Brain Mapping · doi:10.1002/hbm.24513 · Cited by 95 · see citing works
Febo, M., Felix‐Ortiz, A. C., & Johnson, T. R. (2010) · Brain Research · doi:10.1016/j.brainres.2010.02.027 · Cited by 98 · see citing works
Mesolimbic Dopamine Transients in Motivated Behaviors: Focus on Maternal Behavior
Robinson, D. L., Zitzman, D. L., & Williams, S. K. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00023 · Cited by 89 · see citing works
Previous maternal experience affects accumbal dopaminergic responses to pup-stimuli
Afonso, V. M., Grella, S. L., Chatterjee, D., & Fleming, A. S. (2008) · Brain Research · doi:10.1016/j.brainres.2007.12.042 · Cited by 89 · see citing works
Staples, L. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.09.009 · Cited by 89 · see citing works
Sze, Y., & Brunton, P. J. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14615 · Cited by 85 · see citing works
Rocchetti, M., Radua, J., Paloyelis, Y., Xenaki, L., Frascarelli, M., Caverzasi, E., Politi, P., & Fusar‐Poli, P. (2014) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12185 · Cited by 83 · see citing works
Epigenetic legacy of parental experiences: Dynamic and interactive pathways to inheritance
Champagne, F. A. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000808 · Cited by 80 · see citing works
Prolactin and avian parental care: New insights and unanswered questions
Smiley, K. O. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.02.012 · Cited by 83 · see citing works
Hypothalamic control of innate social behaviors
Mei, L., Osakada, T., & Lin, D. (2023) · Science · doi:10.1126/science.adh8489 · Cited by 83 · see citing works
Zhao, C., & Li, M. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.01.023 · Cited by 83 · see citing works
Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice
Okabe, S., Tsuneoka, Y., Takahashi, A., Ooyama, R., Watarai, A., Maeda, S., Honda, Y., Nagasawa, M., Mogi, K., Nishimori, K., et al. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.01.036 · Cited by 82 · see citing works
Lee, S. S., Chronis-Tuscano, A. M., Keenan, K. E., Pelham, W. E., Loney, J., HULLE, C. A. V., Cook, E. H., & LAHEY, B. B. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.102 · Cited by 81 · see citing works
Neural systems and hormones mediating attraction to infant and child faces
Luo, L. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00970 · Cited by 80 · see citing works
Specific maternal brain responses to their own child’s face: An fMRI meta-analysis
Rigo, P., Kim, P., Esposito, G., Putnick, D. L., Venuti, P., & Bornstein, M. H. (2018) · Developmental Review · doi:10.1016/j.dr.2018.12.001 · Cited by 73 · see citing works
Modification of feeding circuits in the evolution of social behavior
Fischer, E. K., & O’Connell, L. A. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.143859 · Cited by 70 · see citing works
Yamamoto, R. T., Dan Ariely, C., Chi, W., Langleben, D. D., & Elman, I. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006042 · Cited by 71 · see citing works
Antagonistic circuits mediating infanticide and maternal care in female mice
Mei, L., Yan, R., Yin, L., Sullivan, R. M., & Lin, D. (2023) · Nature · doi:10.1038/s41586-023-06147-9 · Cited by 73 · see citing works
Oxytocin increases VTA activation to infant and sexual stimuli in nulliparous and postpartum women
Gregory, R., Cheng, H., Rupp, H. A., Sengelaub, D. R., & Heiman, J. R. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.12.009 · Cited by 72 · see citing works
Kinsley, C. H., & Amory, E. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02194.x · Cited by 71 · see citing works
CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice
Akther, S., Korshnova, N., Zhong, J., Liang, M., Михайлович, Ч. С., Lopatina, O., Komleva, Y. K., Salmina, A. B., Nishimura, T., Fakhrul, A. A. K. M., et al. (2013) · Molecular Brain · doi:10.1186/1756-6606-6-41 · Cited by 66 · see citing works
Pereira, M., & Ferreira, A. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.08.005 · Cited by 68 · see citing works
Biosocial Influences on the Family: A Decade Review
D'Onofrio, B. M., & Lahey, B. B. (2010) · Journal of Marriage and the Family · doi:10.1111/j.1741-3737.2010.00729.x · Cited by 67 · see citing works
Explaining individual variation in paternal brain responses to infant cries
Li, T., Horta, M., Mascaro, J. S., Bijanki, K. R., Arnal, L. H., Adams, M. K., Barr, R. G., & Rilling, J. K. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.12.033 · Cited by 66 · see citing works
Jaffee, S. R., & Price, T. S. (2012) · Development and Psychopathology · doi:10.1017/s0954579412000685 · Cited by 67 · see citing works
Many mouths to feed: the control of food intake during lactation.
Woodside, B., Budin, R., Wellman, M. K., & Abizaid, A. (2012) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2012.09.002 · Cited by 54 · see citing works
Posillico, C. K., & Schwarz, J. M. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.11.011 · Cited by 65 · see citing works
Shams, S., Pawluski, J. L., Chatterjee‐Chakraborty, M., Oatley, H., Mastroianni, A., & Fleming, A. S. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.048 · Cited by 64 · see citing works
Seip, K. M., & Morrell, J. I. (2009) · Behavioral Neuroscience · doi:10.1037/a0017666 · Cited by 63 · see citing works
Sexually dimorphic oxytocin receptor-expressing neurons in the preoptic area of the mouse brain
Sharma, K., LeBlanc, R. M., Haque, M., Nishimori, K., Reid, M. M., & Teruyama, R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219784 · Cited by 63 · see citing works
Neural mechanisms of the link between giving social support and health
Inagaki, T. K. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13703 · Cited by 62 · see citing works
Emotional Security Theory and Developmental Psychopathology
Davies, P. T., Martin, M. J., & Sturge‐Apple, M. L. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy106 · Cited by 62 · see citing works
Nelson, L. H., Saulsbery, A. I., & Lenz, K. M. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.09.002 · Cited by 61 · see citing works
Physical presence of spouse enhances brain-to-brain synchrony in co-parenting couples
Azhari, A., Lim, M., Bizzego, A., Gabrieli, G., Bornstein, M. H., & Esposito, G. (2020) · Scientific Reports · doi:10.1038/s41598-020-63596-2 · Cited by 61 · see citing works
Rincón‐Cortés, M., & Grace, A. A. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100839 · Cited by 60 · see citing works
The Roles of Dopamine and α1-Adrenergic Receptors in Cocaine Preferences in Female and Male Rats
Perry, A. N., Westenbroek, C., Jagannathan, L., & Becker, J. B. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.116 · Cited by 59 · see citing works
Banerjee, S. B., & Liu, R. C. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.07.008 · Cited by 58 · see citing works
It takes two! Exploring sex differences in parenting neurobiology and behaviour
Rajhans, P., Goin‐Kochel, R. P., Strathearn, L., & Kim, S. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12721 · Cited by 57 · see citing works
McHenry, J. A., Rubinow, D. R., & Stuber, G. D. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.001 · Cited by 56 · see citing works
Tsuneoka, Y., Tsukahara, S., Yoshida, S., Takase, K., Oda, S., Kuroda, M., & Funato, H. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00026 · Cited by 57 · see citing works
Neuromodulation of maternal circuits by oxytocin
Valtcheva, S., & Froemke, R. C. (2019) · Cell and Tissue Research · doi:10.1007/s00441-018-2883-1 · Cited by 54 · see citing works
Glasper, E. R., Kenkel, W. M., Bick, J. R., & Rilling, J. K. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.02.005 · Cited by 54 · see citing works
Impact of intra‐ and interstrain cross‐fostering on mouse maternal care
Van Der Veen, R., Abrous, D. N., Ronald de Kloet, E., Piazza, P. V., & Koehl, M. (2008) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2007.00337.x · Cited by 54 · see citing works
Lambert, K. G., Franssen, C. L., Bardi, M., Hampton, J. E., Hainley, L., Karsner, S., Tu, E. B., Hyer, M. M., Crockett, A., Baranova, A., et al. (2011) · Brain Behavior and Evolution · doi:10.1159/000326054 · Cited by 53 · see citing works
Pitchers, K. K., Schmid, S., Sebastiano, A. R. D., Wang, X., Laviolette, S. R., Lehman, M. N., & Coolen, L. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034700 · Cited by 53 · see citing works
Wendy Saltzman, A., & Abbott, D. H. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.03.012 · Cited by 53 · see citing works
Stathmin reveals dissociable roles of the basolateral amygdala in parental and social behaviors
Martel, G., Nishi, A., & Shumyatsky, G. P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807507105 · Cited by 53 · see citing works
Experience-dependent mechanisms in the regulation of parental care
Stolzenberg, D. S., & Mayer, H. S. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.04.002 · Cited by 52 · see citing works
Sato, K., Hamasaki, Y., Fukui, K., Ito, K., Miyamichi, K., Minami, M., & Amano, T. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0438-19.2020 · Cited by 50 · see citing works
Prenatal exposure to a low fipronil dose disturbs maternal behavior and reflex development in rats
Udo, M. S. B., Sandini, T. M., Reis-Silva, T. M., Bernardi, M. M., & Spinosa, H. D. S. (2014) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2014.05.010 · Cited by 50 · see citing works
Vitamin D is crucial for maternal care and offspring social behaviour in rats
Yates, N. J., Tesic, D., Feindel, K. W., Smith, J. T., Clarke, M. W., Wale, C. H., Crew, R. C., Wharfe, M. D., Whitehouse, A., & Wyrwoll, C. S. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0008 · Cited by 52 · see citing works
The Prolactin Family of Hormones as Regulators of Maternal Mood and Behavior
Georgescu, T. R., Swart, J. M., Grattan, D. R., & Brown, R. S. E. (2021) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2021.767467 · Cited by 51 · see citing works
Neonatal Exposure to Sevoflurane in Mice Causes Deficits in Maternal Behavior Later in Adulthood
Takaenoki, Y., Satoh, Y., Araki, Y., Kodama, M., Yonamine, R., Yufune, S., & Kazama, T. (2013) · Anesthesiology · doi:10.1097/aln.0000435846.28299.e7 · Cited by 48 · see citing works
Dopamine receptors D1 and D2 are related to observed maternal behavior
Mileva‐Seitz, V. R., Fleming, A. S., Meaney, M. J., Mastroianni, A., Sinnwell, J. P., Steiner, M. S., Atkinson, L. R., Levitan, R. D., Matthews, S. G., Kennedy, J. L., et al. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00804.x · Cited by 48 · see citing works
- Authors
- Numan, M.
- Affiliations
- Boston College (US)
- Corresponding author
- Numan, Michael
- Venue
- Developmental Psychobiology
- Publisher
- Wiley
- Published
- 2006-12-21
- Volume
- 49
- Issue
- 1
- Pages
- 12-21
- ISSN
- 0012-1630 (ISSN-L)
- 1098-2302
- OpenAlex
- W2043549994
- Cited by
- 358
- References
- 29
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 21 · 2023: 17 · 2022: 17 · 2021: 20 · 2020: 19 · 2019: 25 · 2018: 23 · 2017: 19 · 2016: 17 · 2015: 19 · 2014: 14 · 2013: 24 · 2012: 22
- FWCI
- 20.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Developmental Psychobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (0312380)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- maternal behavior, medial preoptic area, rostral hypothalamus, maternal responsiveness, amygdala, anterior hypothalamus, mesolimbic dopamine system, motivation system, neural circuits, rats
- MeSH terms
- Amygdala, Animals, Animals, Newborn, Behavior, Animal, Female, Maternal Behavior, Neurons, Nucleus Accumbens, Preoptic Area, Receptors, Dopamine, Models, Animal, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
