Controversies surrounding the comorbidity of depression and anxiety in inflammatory bowel disease patients: A literature review
Abstract
Psychological disorders are highly prevalent in patients with inflammatory bowel disease (IBD). Anxiety and depression are known to independently affect quality of life and may additionally impair quality of life in IBD over and above the IBD itself. Some researchers have further proposed that anxiety and depression may influence the clinical course of IBD. However, despite the potential for anxiety and depression to play an important role in the clinical picture of IBD, there is little prospective well-controlled research in this area. Probably because of this lack of clear data, researchers dispute the actual role of these psychological disorders in IBD, with a number of conflicting opinions expressed. This article reports on a review of the literature in this field. Herein we discuss the five main areas of controversy regarding IBD and the specific psychological comorbidities of depression and anxiety: 1) the relative rate of cooccurrence of these psychological disorders with IBD; 2) the cooccurrence of these psychological disorders with particular phase of IBD; 3) the cooccurrence of these psychological disorders with the specific type of IBD; 4) the rate of these psychological comorbidities compared both to healthy subjects and to other disease states; and 5) the timing of onset of psychological comorbidity with respect to onset of IBD. Methodological weaknesses of the reviewed studies make it impossible to resolve these controversies. However, the results clearly show that anxiety/depression and IBD frequently interact. Given the long-term illness burden patients with IBD face, further prospective, appropriately controlled studies are needed to adequately answer the question of the precise interplay between anxiety/depression and IBD.
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Psychological comorbidity, such as depressive or anxiety disorders, is thought to be higher amongst those people who have IBS symptoms in addition to IBD or those in the relapse phase of the disease.
“Psychological comorbidity, such as depressive or anxiety disorders, is thought to be higher amongst those people who have IBS symptoms in addition to IBD or those in the relapse phase of the disease. 6”
From Systematic review: the role of psychological stress in inflammatory bowel disease (2022) · cites this paper as [6]
The CHRNA5-CHRNA3-CHRNB4 region has been suggested to contain risk genes for affective disorders such as major depressive disorder.
“the associated CHRNA5-CHRNA3-CHRNB4 region has also been suggested to contain risk genes for affective disorders such as major depressive disorder 49-51”
From Depressive symptoms predict clinical recurrence of inflammatory bowel disease (2022) · cites this paper as [51]
The 2007 review identified five controversies regarding anxiety/depression rates and various comparators between and within IBD.
“A review in 2007 identified five controversies regarding anxiety/depression rates and various comparators between and within IBD (1).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [1]
The quality of the available 17 studies at the time of the previous review was poor, making it difficult to answer the five questions other than to confirm that anxiety and depression were highly prevalent within IBD.
“However, since the quality of the available 17 studies at the time was poor, it was difficult to provide an answer to these questions, other than to confirm that anxiety and depression were highly prevalent within IBD.”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [1]
In 2007, the first author and collaborators published a review paper exploring the comorbidity of anxiety and depression with IBD.
“In 2007, the first author and her collaborators published a review paper exploring the comorbidity of anxiety and depression with IBD (1).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [1]
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- Authors
- Mikocka-Walus, A. A., Turnbull, D. A., Moulding, N. T., Wilson, I. G., Andrews, J. M., & Holtmann, G. J.
- Affiliations
- The University of Adelaide (AU)
- Royal Adelaide Hospital (AU)
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-02
- Volume
- 13
- Issue
- 2
- Pages
- 225-234
- ISSN
- 1078-0998 (ISSN-L)
- OpenAlex
- W2057882590
- Cited by
- 178
- References
- 49
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 3 · 2021: 17 · 2020: 8 · 2019: 9 · 2018: 10 · 2017: 11 · 2016: 11 · 2015: 14 · 2014: 8 · 2013: 11 · 2012: 18
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Inflammatory Bowel Diseases (publishedVersion)
- PubMed (publishedVersion)
- Research Online (University of Wollongong) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Own your potential (DEAKIN) (submittedVersion)
- Figshare (submittedVersion)
- Funders
- Pfizer
- AstraZeneca
- Deutsche Forschungsgemeinschaft
- University of Adelaide
- Royal Adelaide Hospital
- AstraZeneca Australia
- Cilag
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- inflammatory bowel disease, depression
- MeSH terms
- Anxiety Disorders, Depressive Disorder, Humans, Inflammatory Bowel Diseases
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