The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.
Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress
Open accessAbstract
Central endocannabinoid signaling is known to be responsive to stressful stimuli; however, there is no research to date characterizing the effects of stress on peripheral endocannabinoid content. The current study examined serum content of the endocannabinoid ligands N-arachidonylethanolamide (anandamide; AEA) and 2-arachidonoylglycerol (2-AG), and the non-cannabinoid N-acyl ethanolamine (NAE) molecules palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) under basal conditions, immediately following the Trier Social Stress Test (TSST), and 30 min thereafter, in 15 medication-free women diagnosed with major depression, and 15 healthy matched controls. Basal serum concentrations of AEA and 2-AG, but not PEA or OEA, were significantly reduced in women with major depression relative to matched controls, indicating a deficit in peripheral endocannabinoid activity. Immediately following the TSST, serum 2-AG concentrations were increased compared to baseline; serum AEA concentration was unchanged at this time point. Serum concentrations of PEA and OEA were significantly lower than baseline 30 min following the cessation of the TSST. The magnitude of these responses did not differ between depressed and control subjects. These are the first data to demonstrate that the peripheral endocannabinoid/NAE system is responsive to exposure to stress.
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“The endocannabinoids anandamide (AEA) and 2arachidonoylglycerol (2AG) are endogenously produced lipids that have been found, for instance, to be elevated in blood in response to psychological stress (Hill et al., 2009;Dlugos et al., 2012).”
From Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans (2016) · cites this paper as Hill et al., 2009
In the citing paper
“Similar effects have been found after acute psychological stress (Hill et al., 2009).”
From Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans (2016) · cites this paper as Hill et al., 2009
In the citing paper
“a number of studies have detected reduced levels of AEA in patients suffering from stress-related psychiatric illnesses, including major depression (Hill et al., 2009) and PTSD (Neumeister et al., 2013).”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Hill et al., 2009
In the citing paper
“two independent studies have now both reported that 2-AG levels are reduced in individuals with major depression (Hill et al., 2008; Hill et al., 2009)”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Hill et al., 2009
In the citing paper
“EC plasma concentrations are also modified by the presence of affective disorders and severe mental illness [7], [8].”
From Plasma concentrations of endocannabinoids and related primary fatty acid amides in patients with post-traumatic stress disorder (2013) · cites this paper as [7]
In the citing paper
“there are a number of recent studies which demonstrated that EC and NAE blood concentrations increase in response to acute stress [7], [10] and that they are higher in individuals who show stress tolerance [10] and lower in patients with depression [18].”
From Plasma concentrations of endocannabinoids and related primary fatty acid amides in patients with post-traumatic stress disorder (2013) · cites this paper as [7]
In the citing paper
“The possible protective effects of an activated EC system are illustrated by the fact that patients with major depression show reduced serum ANA and 2-AG concentrations [7]”
From Plasma concentrations of endocannabinoids and related primary fatty acid amides in patients with post-traumatic stress disorder (2013) · cites this paper as [7]
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Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
Robins, L. N. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780290015001 · Cited by 5,219
Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study
Spitzer, R. L. (1994) · JAMA · doi:10.1001/jama.272.22.1749 · Cited by 2,648
Utility of a New Procedure for Diagnosing Mental Disorders in Primary Care: The PRIME-MD 1000 Study
Spitzer, R. L. (1994) · JAMA · doi:10.1001/jama.1994.03520220043029 · Cited by 1,873
Endocrinology of the stress response
Charmandari, E., Tsigos, C., & Chrousos, G. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.120816 · Cited by 1,799
Fu, J., Gaetani, S., Oveisi, F., Verme, J., Serrano, A., de Fonseca, F. D., Rosengarth, A., Luecke, H., Giacomo, B. D., Tarzia, G., et al. (2003) · Nature · doi:10.1038/nature01921 · Cited by 1,113
Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials
Christensen, R., Kristensen, P. K., Bartels, E. M., Bliddal, H., & Astrup, A. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61721-8 · Cited by 1,097
Lo Verme, J., Fu, J., Astarita, G., La Rana, G., Russo, R., Calignano, A., & Piomelli, D. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.006353 · Cited by 882
Pace, T. W. W., Mletzko, T. C., Alagbe, O., Musselman, D. L., Nemeroff, C. B., Miller, A. H., & Heim, C. M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1630 · Cited by 810
Kirschbaum, C., Prussner, J. C., Stone, A. A., Federenko, I., Gaab, J., Lintz, D., Schommer, N., & Hellhammer, D. H. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199509000-00009 · Cited by 666
Pace, T. W. W., Hu, F., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.08.009 · Cited by 621
Howlett, A. C. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00060-6 · Cited by 562
Ishac, E. J. N., Jiang, L., Lake, K. D., Varga, K., Abood, M. E., & Kunos, G. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15639.x · Cited by 352
Cannabinoid Receptors and Endocannabinoids: Evidence for New Players
Mackie, K., & Stella, N. (2006) · The AAPS Journal · doi:10.1007/bf02854900 · Cited by 303
Serum Endocannabinoid Content is Altered in Females with Depressive Disorders: A Preliminary Report
Hill, M., Miller, G., Ho, W.-S., Gorzalka, B., & Hillard, C. (2008) · Pharmacopsychiatry · doi:10.1055/s-2007-993211 · Cited by 292
Clinical depression and regulation of the inflammatory response during acute stress
Miller, G. E., Rohleder, N., Stetler, C., & Kirschbaum, C. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000174172.82428.ce · Cited by 253
Simon, G. M., & Cravatt, B. F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707807200 · Cited by 232
Gorzalka, B. B., Hill, M. N., & Hillard, C. J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.004 · Cited by 211
Hill, M. N., & Gorzalka, B. B. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00006 · Cited by 196
Role of the endocannabinoid system in regulation of the hypothalamic-pituitary-adrenocortical axis
Steiner, M. S., & Wotjak, C. T. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00433-0 · Cited by 174
Endogenous Cannabinoids: Structure and Metabolism
Bisogno, T. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01676.x · Cited by 170
Berdyshev, E. V., Boichot, E., Germain, N., Allain, N., Anger, J.-P., & Lagente, V. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01007-8 · Cited by 168
Freedland, K. E., Skala, J. A., Carney, R. M., Raczynski, J. M., Taylor, C. B., de Leon, C. F. M., Ironson, G. H., Youngblood, M., Krishnan, K., & Veith, R. C. (2002) · Psychosomatic Medicine · doi:10.1097/01.psy.0000028826.64279.29 · Cited by 156
Matias, I., Bisogno, T., & Marzo, V. D. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803271 · Cited by 154
Cannabinoid Receptors and Endocannabinoids: Evidence for New Players
Mackie, K., & Stella, N. (2006) · The AAPS Journal · doi:10.1208/aapsj080234 · Cited by 149
Role and regulation of acylethanolamides in energy balance: focus on adipocytes and β‐cells
Matias, I., Gonthier, M., Petrosino, S., Docimo, L., Capasso, R., Hoareau, L., Monteleone, P., Roche, R., Izzo, A. A., & Marzo, V. D. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707424 · Cited by 109
Impairments in Endocannabinoid Signaling and Depressive Illness
Hill, M. N. (2009) · JAMA · doi:10.1001/jama.2009.369 · Cited by 69
Endocannabinoids and the haematological system
Randall, M. D. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707420 · Cited by 50
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Psychogios, N., Hau, D., Peng, J., Guo, A. C., Mandal, R., Bouatra, S., Sinelnikov, I. V., Krishnamurthy, R., Eisner, R., Gautam, B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016957 · Cited by 1,779
Neurobiological Interactions Between Stress and the Endocannabinoid System
Morena, M., Patel, S., Bains, J. S., & Hill, M. N. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.166 · Cited by 698
Multiple Functions of Endocannabinoid Signaling in the Brain
Katona, I., & Freund, T. F. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150420 · Cited by 630
Ligresti, A., PETROCELLIS, L. D., & Marzo, V. D. (2016) · Physiological Reviews · doi:10.1152/physrev.00002.2016 · Cited by 505
Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?
Hillard, C. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.130 · Cited by 449
Metadata
- Authors
- Hill, M. N., Miller, G. E., Carrier, E. J., Gorzalka, B. B., & Hillard, C. J.
- Affiliations
- University of British Columbia (CA)
- Medical College of Wisconsin (US)
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 34
- Issue
- 8
- Pages
- 1257-1262
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC2716432
- OpenAlex
- W2097199164
- Cited by
- 328
- References
- 30
- Citations by year
- 2026: 14 · 2025: 22 · 2024: 29 · 2023: 19 · 2022: 25 · 2021: 37 · 2020: 23 · 2019: 22 · 2018: 22 · 2017: 17 · 2016: 15 · 2015: 18 · 2014: 8 · 2013: 20 · 2012: 12
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01DA009155)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- endocannabinoids, N-acylethanolamines, major depressive disorder, social stress, anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, oleoylethanolamide, serum biomarkers, Trier Social Stress Test, women, stress response
- MeSH terms
- Adult, Amides, Arachidonic Acids, Major Depressive Disorder, Ethanolamines, Female, Glycerides, Humans, Oleic Acids, Palmitic Acids, Stress, Psychological, Case-Control Studies, Polyunsaturated Alkamides, Cannabinoid Receptor Modulators, Endocannabinoids
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