CoChat
Sign Up
Cited by 211Neuroendocrine regulation and behaviorMemory and Neural MechanismsOlfactory and Sensory Function Studies

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Oxytocin mediates rodent social memory within the lateral septum and the medial amygdala depending on the relevance of the social stimulus: Male juvenile versus female adult conspecifics

Lukas, Michael, Toth, Iulia, Veenema, Alexa H., Neumann, Inga D.·2013·Psychoneuroendocrinology
DOI 10.1016/j.psyneuen.2012.09.018
Open this paper in CoChat — free account

Abstract

Brain oxytocin (OXT) plays an important role in short-term social memory in laboratory rodents. Here we monitored local release of OXT and its functional involvement in the maintenance and retrieval of social memory during the social discrimination test. We further assessed, if the local effects of OXT within the medial amygdala (MeA) and lateral septum (LS) on social discrimination abilities were dependent on the biological relevance of the social stimulus, thus comparing male juvenile versus adult female conspecifics. OXT release was increased in the LS of male rats during the retrieval, but not during the acquisition or maintenance, of social memory for male juvenile stimuli. Blockade of OXT activity by intracerebroventricular (ICV) administration of a specific OXT receptor antagonist (OXTR-A, rats: 0.75 μg/5 μl, mice: 2 μg/2 μl) immediately after acquisition of social memory impaired the maintenance of social memory, and consequently discrimination abilities during retrieval of social memory. In contrast, ICV OXTR-A was without effect when administered 20 min prior to retrieval of social memory in both species. Non-social memory measured in the object discrimination test was not affected by ICV OXTR-A in male mice, indicating that brain OXT is mainly required for memory formation in a social context. The biological relevance of the social stimulus seems to importantly determine social memory abilities, as male rats recognized a previously encountered female adult stimulus for at least 2h (versus 60 min for male juveniles), with a region-dependent contribution of endogenous OXT; while bilateral administration of OXTR-A into the MeA (0.1 μg/1 μl) impaired social memory for adult females only, administration of OXTR-A into the LS via retrodialysis (10 μg/ml, 1.0 μl/min) impaired social memory for both male juveniles and female adults. Overall, these results indicate that brain OXT is a critical mediator of social memory in male rodents and that, depending on the biological relevance of the social stimulus, distinct brain regions are recruited to mediate its effects.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.psyneuen.2012.09.018

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 43 references

Cited by

Sorted by citations

Items 101–200 of 211

Related

See all

Metadata

Authors
Lukas, M., Toth, I., Veenema, A. H., & Neumann, I. D.
Affiliations
University of Regensburg (DE)
ORCID
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2013-06
Volume
38
Issue
6
Pages
916-926
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/j.psyneuen.2012.09.018
OpenAlex
W2105088884
Cited by
211
References
43
Citations by year
2026: 9 · 2025: 9 · 2024: 26 · 2023: 18 · 2022: 19 · 2021: 12 · 2020: 15 · 2019: 18 · 2018: 21 · 2017: 13 · 2016: 18 · 2015: 14 · 2014: 11 · 2013: 7
FWCI
15.91
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords
oxytocin, social memory, lateral septum, medial amygdala, social discrimination, memory retrieval, memory maintenance, sex differences, retrodialysis, object discrimination, rats, mice
MeSH terms
Amygdala, Animals, Cues, Discrimination, Psychological, Female, Male, Memory, Short-Term, Ornipressin, Oxytocin, Septal Nuclei, Receptors, Oxytocin, Mice, Rats, Infusions, Intraventricular, Social Discrimination

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review