The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Oxytocin mediates rodent social memory within the lateral septum and the medial amygdala depending on the relevance of the social stimulus: Male juvenile versus female adult conspecifics
Abstract
Brain oxytocin (OXT) plays an important role in short-term social memory in laboratory rodents. Here we monitored local release of OXT and its functional involvement in the maintenance and retrieval of social memory during the social discrimination test. We further assessed, if the local effects of OXT within the medial amygdala (MeA) and lateral septum (LS) on social discrimination abilities were dependent on the biological relevance of the social stimulus, thus comparing male juvenile versus adult female conspecifics. OXT release was increased in the LS of male rats during the retrieval, but not during the acquisition or maintenance, of social memory for male juvenile stimuli. Blockade of OXT activity by intracerebroventricular (ICV) administration of a specific OXT receptor antagonist (OXTR-A, rats: 0.75 μg/5 μl, mice: 2 μg/2 μl) immediately after acquisition of social memory impaired the maintenance of social memory, and consequently discrimination abilities during retrieval of social memory. In contrast, ICV OXTR-A was without effect when administered 20 min prior to retrieval of social memory in both species. Non-social memory measured in the object discrimination test was not affected by ICV OXTR-A in male mice, indicating that brain OXT is mainly required for memory formation in a social context. The biological relevance of the social stimulus seems to importantly determine social memory abilities, as male rats recognized a previously encountered female adult stimulus for at least 2h (versus 60 min for male juveniles), with a region-dependent contribution of endogenous OXT; while bilateral administration of OXTR-A into the MeA (0.1 μg/1 μl) impaired social memory for adult females only, administration of OXTR-A into the LS via retrodialysis (10 μg/ml, 1.0 μl/min) impaired social memory for both male juveniles and female adults. Overall, these results indicate that brain OXT is a critical mediator of social memory in male rodents and that, depending on the biological relevance of the social stimulus, distinct brain regions are recruited to mediate its effects.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Likewise, the same dose of OTR-A impaired social recognition when injected into the lateral septum (Lukas et al., 2013)”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Lukas et al., 2013
In the citing paper
“even though the dose that we used impaired social recognition in adult male rats (Lukas et al., 2013) and in juvenile male rats (Veenema, unpublished observation).”
From Sex-specific modulation of juvenile social play by vasopressin (2013) · cites this paper as Lukas et al., 2013
In the citing paper
“ICV administration of an OTR antagonist impaired social recognition in both male (Lukas et al., 2013) and female (Engelmann et al., 1998) rats.”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Lukas et al., 2013
In the citing paper
“Utilizing the three-chamber social memory assay in rodents, it was found that OXT activity in the septum and amygdala is required for social memory [43,70].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [70]
In the citing paper
“OXT is released within the brain as relationships form and it facilitates experience-dependent social adaptations including the formation of social memories 14,15, the establishment of mating-induced pair bonds 2 and maternal responsiveness 16.”
From Social experience alters oxytocinergic modulation in the nucleus accumbens of female prairie voles (2022) · cites this paper as [15]
In the citing paper
“and the well-established role of oxytocin in social behaviors and social recognition (13, 21, 34; 39-44).”
From Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus (2024) · cites this paper as [40]
Citations
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043
Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice
Takayanagi, Y., Yoshida, M., Bielsky, I. F., Ross, H. E., Kawamata, M., Onaka, T., Yanagisawa, T., Kimura, T., Matzuk, M. M., Young, L. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505312102 · Cited by 806
Oxytocin, vasopressin, and social recognition in mammals
Bielsky, I. F., & Young, L. J. (2004) · Peptides · doi:10.1016/j.peptides.2004.05.019 · Cited by 460
Tribollet, E., Barberis, C., Jard, S., Dubois-Dauphin, M., & Dreifuss, J. J. (1988) · Brain Research · doi:10.1016/0006-8993(88)91437-0 · Cited by 442
Modulation of social memory in male rats by neurohypophyseal peptides
Dantzer, R., Bluthe, R. M., Koob, G. F., & Le Moal, M. (1987) · Psychopharmacology · doi:10.1007/bf00518192 · Cited by 423
Lukas, M., Toth, I., Reber, S. O., Slattery, D. A., Veenema, A. H., & Neumann, I. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.95 · Cited by 403
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–211 of 211
Gumerova, A. A., Pevnev, G., Korkmaz, F., Cheliadinova, U., Burganova, G., Vasilyeva, D., Cullen, L., Barak, O., Sultana, F., Zhou, W., et al. (2025) · eLife · doi:10.7554/elife.105355.1
Gumerova, A. A., Pevnev, G., Korkmaz, F., Cheliadinova, U., Burganova, G., Vasilyeva, D., Cullen, L., Barak, O., Sultana, F., Zhou, W., et al. (2025) · eLife · doi:10.7554/elife.105355 · Cited by 1
Raftogianni, A., Lydia, P., Sofia, G., Kalpachidou, T., Stylianopoulou, F., & Stamatakis, A. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70326
Gumerova, A. A., Pevnev, G., Korkmaz, F., Cheliadinova, U., Burganova, G., Vasilyeva, D., Cullen, L., Barak, O., Sultana, F., Zhou, W., et al. (2026) · eLife · doi:10.7554/elife.105355.2
Zhang, L., Huang, M., Ye, C.-L., Tang, Z., Xu, M., Yuan, W. A. N. G., Wang, T., Luo, S., Ji, R., Yu, C., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69955-3
Zoicas, I., Sucu, B., Kornhuber, J., & Fejtová, A. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107362 · Cited by 1
Bertoni, A. (2019) · theses.fr (ABES) · doi:10.70675/d43fcf44zc66ez47a1zae43zd20439e2b233
Circuit logic of oxytocin and vasopressin complementary actions
Jeanneteau, F. D., Chakraborty, P., Petitjean, H., & Charlet, A. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1875731
Ze-ming, Z., Wang, D., Tang, W.-J., Chen, X.-L., Li, H., Li, G., Xiao, R., Xu, L.-H., Si, W.-K., & Chen, Z.-Y. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117854
Wang, J., Cai, F., Zhu, Q., Song, Z., Zhang, H., Wang, H., Duan, J., Huang, H., & Xu, Y. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1834610
Metadata
- Authors
- Lukas, M., Toth, I., Veenema, A. H., & Neumann, I. D.
- Affiliations
- University of Regensburg (DE)
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 38
- Issue
- 6
- Pages
- 916-926
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2105088884
- Cited by
- 211
- References
- 43
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 26 · 2023: 18 · 2022: 19 · 2021: 12 · 2020: 15 · 2019: 18 · 2018: 21 · 2017: 13 · 2016: 18 · 2015: 14 · 2014: 11 · 2013: 7
- FWCI
- 15.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, social memory, lateral septum, medial amygdala, social discrimination, memory retrieval, memory maintenance, sex differences, retrodialysis, object discrimination, rats, mice
- MeSH terms
- Amygdala, Animals, Cues, Discrimination, Psychological, Female, Male, Memory, Short-Term, Ornipressin, Oxytocin, Septal Nuclei, Receptors, Oxytocin, Mice, Rats, Infusions, Intraventricular, Social Discrimination
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
