The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Oxytocin mediates rodent social memory within the lateral septum and the medial amygdala depending on the relevance of the social stimulus: Male juvenile versus female adult conspecifics
Abstract
Brain oxytocin (OXT) plays an important role in short-term social memory in laboratory rodents. Here we monitored local release of OXT and its functional involvement in the maintenance and retrieval of social memory during the social discrimination test. We further assessed, if the local effects of OXT within the medial amygdala (MeA) and lateral septum (LS) on social discrimination abilities were dependent on the biological relevance of the social stimulus, thus comparing male juvenile versus adult female conspecifics. OXT release was increased in the LS of male rats during the retrieval, but not during the acquisition or maintenance, of social memory for male juvenile stimuli. Blockade of OXT activity by intracerebroventricular (ICV) administration of a specific OXT receptor antagonist (OXTR-A, rats: 0.75 μg/5 μl, mice: 2 μg/2 μl) immediately after acquisition of social memory impaired the maintenance of social memory, and consequently discrimination abilities during retrieval of social memory. In contrast, ICV OXTR-A was without effect when administered 20 min prior to retrieval of social memory in both species. Non-social memory measured in the object discrimination test was not affected by ICV OXTR-A in male mice, indicating that brain OXT is mainly required for memory formation in a social context. The biological relevance of the social stimulus seems to importantly determine social memory abilities, as male rats recognized a previously encountered female adult stimulus for at least 2h (versus 60 min for male juveniles), with a region-dependent contribution of endogenous OXT; while bilateral administration of OXTR-A into the MeA (0.1 μg/1 μl) impaired social memory for adult females only, administration of OXTR-A into the LS via retrodialysis (10 μg/ml, 1.0 μl/min) impaired social memory for both male juveniles and female adults. Overall, these results indicate that brain OXT is a critical mediator of social memory in male rodents and that, depending on the biological relevance of the social stimulus, distinct brain regions are recruited to mediate its effects.
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“Likewise, the same dose of OTR-A impaired social recognition when injected into the lateral septum (Lukas et al., 2013)”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Lukas et al., 2013
In the citing paper
“even though the dose that we used impaired social recognition in adult male rats (Lukas et al., 2013) and in juvenile male rats (Veenema, unpublished observation).”
From Sex-specific modulation of juvenile social play by vasopressin (2013) · cites this paper as Lukas et al., 2013
In the citing paper
“ICV administration of an OTR antagonist impaired social recognition in both male (Lukas et al., 2013) and female (Engelmann et al., 1998) rats.”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Lukas et al., 2013
In the citing paper
“Utilizing the three-chamber social memory assay in rodents, it was found that OXT activity in the septum and amygdala is required for social memory [43,70].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [70]
In the citing paper
“OXT is released within the brain as relationships form and it facilitates experience-dependent social adaptations including the formation of social memories 14,15, the establishment of mating-induced pair bonds 2 and maternal responsiveness 16.”
From Social experience alters oxytocinergic modulation in the nucleus accumbens of female prairie voles (2022) · cites this paper as [15]
In the citing paper
“and the well-established role of oxytocin in social behaviors and social recognition (13, 21, 34; 39-44).”
From Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus (2024) · cites this paper as [40]
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“However, ICV administration of an OTR antagonist impaired social recognition in both male (Lukas et al., 2013) and female (Engelmann et al., 1998) rats.”
BackgroundOxytocin enhances social recognition by modulating cortical control of early olfactory processing
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Metadata
- Authors
- Lukas, M., Toth, I., Veenema, A. H., & Neumann, I. D.
- Affiliations
- University of Regensburg (DE)
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 38
- Issue
- 6
- Pages
- 916-926
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2105088884
- Cited by
- 211
- References
- 43
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 26 · 2023: 18 · 2022: 19 · 2021: 12 · 2020: 15 · 2019: 18 · 2018: 21 · 2017: 13 · 2016: 18 · 2015: 14 · 2014: 11 · 2013: 7
- FWCI
- 15.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, social memory, lateral septum, medial amygdala, social discrimination, memory retrieval, memory maintenance, sex differences, retrodialysis, object discrimination, rats, mice
- MeSH terms
- Amygdala, Animals, Cues, Discrimination, Psychological, Female, Male, Memory, Short-Term, Ornipressin, Oxytocin, Septal Nuclei, Receptors, Oxytocin, Mice, Rats, Infusions, Intraventricular, Social Discrimination
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