The DOI matches its Crossref record; 204 of the 204 references it cites were found in a registry or an index.
The three-hit concept of vulnerability and resilience: Toward understanding adaptation to early-life adversity outcome
Open accessAbstract
Stressful experiences during early-life can modulate the genetic programming of specific brain circuits underlying emotional and cognitive aspects of behavioral adaptation to stressful experiences later in life. Although this programming effect exerted by experience-related factors is an important determinant of mental health, its outcome depends on cognitive inputs and hence the valence an individual assigns to a given environmental context. From this perspective we will highlight, with studies in rodents, non-human primates and humans, the three-hit concept of vulnerability and resilience to stress-related mental disorders, which is based on gene-environment interactions during critical phases of perinatal and juvenile brain development. The three-hit (i.e., hit-1: genetic predisposition, hit-2: early-life environment, and hit-3: later-life environment) concept accommodates the cumulative stress hypothesis stating that in a given context vulnerability is enhanced when failure to cope with adversity accumulates. Alternatively, the concept also points to the individual’s predictive adaptive capacity, which underlies the stress inoculation and match/mismatch hypotheses. The latter hypotheses propose that the experience of relatively mild early-life adversity prepares for the future and promotes resilience to similar challenges in later-life; when a mismatch occurs between early and later-life experience, coping is compromised and vulnerability is enhanced. The three-hit concept is fundamental for understanding how individuals can either be prepared for coping with life to come and remain resilient or are unable to do so and succumb to a stress-related mental disorder, under seemingly identical circumstances.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Accordingly, this shift from a hyper- to a hypo-responsive stress axis in the first 5 years in life may be represent an particularly crucial stress-sensitive period, especially in the absence of a nurturing caregiver (104).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [104]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“After an initial hyper-responsive period, the HPA axis may later transition into a stress hypo-responsive period (SHRP) with lower basal cortisol levels and blunted stress-induced cortisol reactivity (101, 104–106).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [104]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The classical vulnerabilitystress model of mental disorders, arguably one of the most influential models of disorder development, as well as conceptually similar approaches such as the”
From The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention (2020) · cites this paper as Daskalakis, Bagot, Parker, Vinkers, & de Kloet, 2013
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Taken together, enduring changes in the transcriptome may facilitate the response to early developmental challenges and thus play a central role in the long-term (and sometimes transgenerational) biological trajectories of stress-related disease through programming effects for stress reactivity after ELS/CT exposure (104, 413, 414).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [104]
The cited source says what the claim attributes to it.
In the citing paper
“Recently, Daskalakis et al. (104) have expanded this model suggesting a three-hit concept for vulnerability and resilience.”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [104]
The cited source says what the claim attributes to it.
In the citing paper
“Accordingly, vulnerability in a given context is enhanced when failure to cope with adversity accumulates.”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [104]
The cited source says what the claim attributes to it.
In the citing paper
“The interaction of the individual genetic background (hit-1) with ELS/CT exposure (hit-2) results in an evolving phenotype with altered stress axis regulation and sensitivity due to early developmental programming, which, in turn, interacts with later-life challenges (hit-3) to result in a higher or lower vulnerability risk according to the type of challenge experienced.”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [104]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177
Stress, adaptation, and disease. Allostasis and allostatic load
McEWEN, B. S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09546.x · Cited by 5,092
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531
Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170
Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R. (1998) · Endocrine Reviews · doi:10.1210/er.19.3.269 · Cited by 2,614
Self-citationCausal Relationship Between Stressful Life Events and the Onset of Major Depression
Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.837 · Cited by 2,566 · cited 2×
“, events that are directly related to an individual’s own behavior (Kendler et al., 1999).”
Background
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 582
Morató, L., Astori, S., Zalachoras, I., Rodrigues, J., Ghosal, S., Huang, W., de Suduiraut, I. G., Grosse, J., Zanoletti, O., Cao, L., et al. (2022) · Science Advances · doi:10.1126/sciadv.abj9109 · Cited by 51
Albertella, L., Rotaru, K., Christensen, E., Lowe, A., Brierley, M., Richardson, K. E., Chamberlain, S. R., Lee, R. S. C., Kayayan, E., Grant, J. E., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.634583 · Cited by 50
Tung, I., Hipwell, A. E., Grosse, P. J., Battaglia, L. P., Cannova, E., English, G. E., Quick, A. D., Llamas, B., Taylor, M., & Foust, J. E. (2023) · Psychological Bulletin · doi:10.1037/bul0000407 · Cited by 55
Saavedra, L. M., Navarro, B. F., & Torner, L. (2017) · NeuroImmunoModulation · doi:10.1159/000485383 · Cited by 56
Nolvi, S., Uusitupa, H., Bridgett, D. J., Pesonen, H., Aatsinki, A., Kataja, E., Korja, R., Karlsson, H., & Karlsson, L. (2017) · Developmental Science · doi:10.1111/desc.12625 · Cited by 56
Psychological Predictors of Unhealthy Eating Attitudes in Young Adults
Izydorczyk, B., Sitnik‐Warchulska, K., Lizińczyk, S., & Lipiarz, A. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00590 · Cited by 49
Jawad, M. Y., Meshkat, S., Tabassum, A., Mckenzie, A., Vincenzo, J. D. D., Guo, Z., Musavi, N. B., Phan, L., Ceban, F., Kwan, A. T. H., et al. (2022) · CNS Spectrums · doi:10.1017/s1092852922001043 · Cited by 48
Childhood Bereavement and Lower Stress Resilience in Late Adolescence
Kennedy, B., Chen, R., Valdimarsdóttir, U. A., Montgomery, S., Fang, F., & Fall, K. (2018) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2018.02.002 · Cited by 51
Usacheva, M., Choe, D. E., Liu, S., Timmer, S., & Belsky, J. (2022) · Development and Psychopathology · doi:10.1017/s0954579422000013 · Cited by 51
Zalosnik, M. I., Pollano, A., Trujillo, V., Suárez, M. M., & Durando, P. E. (2014) · Stress · doi:10.3109/10253890.2014.936005 · Cited by 47
Environmental and neurodevelopmental contributors to youth mental illness
Whittle, S., Zhang, L., & Rakesh, D. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01926-y · Cited by 49
A Comprehensive Overview of Stress, Resilience, and Neuroplasticity Mechanisms
Buenrostro-Jáuregui, M. H., Muñoz-Sánchez, S., Rojas-Hernández, J., Alonso-Orozco, A. I., Vega‐Flores, G., Tapia-de-Jesús, A., & Leal‐Galicia, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073028 · Cited by 50
Chaudhury, S., Aurbach, E. L., Sharma, V., Blandino, P., Turner, C. A., Watson, S. J., & Akil, H. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411618111 · Cited by 46
Dissel, S., Seugnet, L., Thimgan, M. S., Silverman, N. S., Angadi, V., Thacher, P. V., Burnham, M. M., & Shaw, P. J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.09.019 · Cited by 50
Cingulate-basal ganglia-thalamo-cortical aspects of catatonia and implications for treatment
Fricchione, G. L., & Beach, S. R. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64196-0.00012-1 · Cited by 48
Cumulative lifetime stress exposure predicts greater impulsivity and addictive behaviors
McMullin, S. D., Shields, G. S., Slavich, G. M., & Buchanan, T. W. (2020) · Journal of Health Psychology · doi:10.1177/1359105320937055 · Cited by 46
Early adversity, immunity and infectious disease
Avitsur, R., Levy, S., Goren, N., & Grinshpahet, R. (2015) · Stress · doi:10.3109/10253890.2015.1017464 · Cited by 45
Keers, R., & Pluess, M. (2017) · Development and Psychopathology · doi:10.1017/s0954579417001493 · Cited by 51
Childhood maltreatment and risk for suicide attempts in major depression: a sex-specific approach
Goldberg, X., Serra-Blasco, M., Vicent-Gil, M., Aguilar, E., Ros, L., Arias, B., Courtet, P., Palao, D. J., & Cardoner, N. (2019) · European Journal of Psychotraumatology · doi:10.1080/20008198.2019.1603557 · Cited by 48
Galatzer‐Levy, I. R., Ruggles, K. V., & Chen, Z. S. (2018) · Chronic Stress · doi:10.1177/2470547017747553 · Cited by 50
Keilow, M., Wu, C., & Obel, C. (2020) · SSM - Population Health · doi:10.1016/j.ssmph.2020.100548 · Cited by 44
Schizophrenia in the Spectrum of Gene-Stress Interactions: The FKBP5 Example
Daskalakis, N. P., & Binder, E. B. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu189 · Cited by 45
Self-citationFuentes, S., Daviu, N., Gagliano, H., Garrido, P., Zelena, D., Monasterio, N., Armario, A., & Nadal, R. A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00056 · Cited by 47
Chocyk, A., Majcher‐Maślanka, I., Przyborowska, A., Maćkowiak, M., & Wędzony, K. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.05.002 · Cited by 45
Criado‐Marrero, M., Gebru, N. T., Gould, L. A., Smith, T. M., Kim, S., Blackburn, R. J., Dickey, C. A., & Blair, L. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112738 · Cited by 44
Aligning physiology with psychology: Translational neuroscience in neuropsychiatric drug discovery
McArthur, R. A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.004 · Cited by 42
Psychometric validation of the French version of the Connor-Davidson Resilience Scale
Guihard, G., Deumier, L., Alliot‐Licht, B., Bouton-Kelly, L., Michaut, C., & Quilliot, F. (2017) · L Encéphale · doi:10.1016/j.encep.2017.06.002 · Cited by 50
Pillai, A. G., Arp, M., Velzing, E. H., Lesuis, S. L., Schmidt, M. V., Holsboer, F., Joëls, M., & Krugers, H. J. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.02.001 · Cited by 44
Wei, Y., Wang, G., Wang, H., He, J., Zhang, N., Wu, Z., Xiao, L., & Yang, C. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.04.034 · Cited by 43
Locci, A., & Pinna, G. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.12.014 · Cited by 42
Bonapersona, V., Joëls, M., & Sarabdjitsingh, R. A. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.003 · Cited by 44
FKBP5 and early life stress affect the hippocampus by an age-dependent mechanism
Criado‐Marrero, M., Smith, T. M., Gould, L. A., Kim, S., Penny, H. J., Sun, Z., Gulick, D., Dickey, C. A., & Blair, L. J. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100143 · Cited by 45
Claypoole, L. D., Zimmerberg, B., & Williamson, L. L. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.08.017 · Cited by 41
Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone
Harris, G., Eschment, M., Orozco, S. P., McCaffery, J. M., Maclennan, R., Severín, D., Leist, M., Kleensang, A., Pamies, D., Maertens, A., et al. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2250-8 · Cited by 42
Neurobiological Trajectories Involving Social Isolation in PTSD: A Systematic Review
Vlachos, I. I., Papageorgiou, C., & Margariti, M. M. (2020) · Brain Sciences · doi:10.3390/brainsci10030173 · Cited by 40
Aging, Social Distancing, and COVID-19 Risk: Who is more Vulnerable and Why?
Faraji, J., & Metz, G. A. S. (2021) · Aging and Disease · doi:10.14336/ad.2021.0319 · Cited by 44
Alexander‐Bloch, A. F., Huguet, G., Schultz, L. M., Huffnagle, N., Jacquemont, S., Seidlitz, J., Saci, Z., Moore, T. M., Bethlehem, R. A. I., Mollon, J., et al. (2022) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2022.1017 · Cited by 43
Translational models of stress and resilience: An applied neuroscience methodology review
Albayrak, Z. S., Vaz, A., Bordes, J., Ünlü, S., Sep, M. S. C., Vinkers, C. H., Pinto, L., & Eser, H. Y. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.104064 · Cited by 43
Self-citationFarkas, J. I., Kovács, L. Á., Gáspár, L., Nafz, A. E., Gaszner, T., Ujvari, B., Kormos, V., CSERNUS, V. J., Hashimoto, H., Reglődi, D., et al. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.019 · Cited by 42
Basson, R. J., O’Loughlin, J. I., Weinberg, J., Young, A. H., Bodnar, T. S., & Brotto, L. A. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.03.001 · Cited by 40
Sanwald, S., Widenhorn‐Müller, K., Schönfeldt‐Lecuona, C., Connemann, B. J., Gahr, M., Kammer, T., Montag, C., & Kiefer, M. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03166-6 · Cited by 39
The Pathways between Cortisol-Related Regulation Genes and PTSD Psychotherapy
Castro-Vale, I., & Carvalho, D. M. (2020) · Healthcare · doi:10.3390/healthcare8040376 · Cited by 39
de Kloet, E. R. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100352 · Cited by 37
Niu, L., Gao, Q., Xie, M., Yip, T., Gunnar, M. R., Wang, W., Xu, Q., Zhang, Y., & Lin, D. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106124 · Cited by 40
Long-term effects of early environment on the brain: Lesson from rodent models
Segni, M. D., Andolina, D., & Ventura, R. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.09.039 · Cited by 38
Cognitive flexibility mediates the association between early life stress and habitual behavior
Zhou, X., Meng, Y., Schmitt, H., Montag, C., Kendrick, K. M., & Becker, B. (2020) · Personality and Individual Differences · doi:10.1016/j.paid.2020.110231 · Cited by 37
Fontana, B. D., Gibbon, A. J., Cleal, M., Norton, W., & Parker, M. O. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110087 · Cited by 36
Context Modulates Outcome of Perinatal Glucocorticoid Action in the Brain
de Kloet, E. R., Claessens, S. E. F., & Kentrop, J. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00100 · Cited by 36
Hu, D., Yu, Z., Zhang, Y., Han, Y., Zhang, W., Lü, L., & Shi, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-12183-z · Cited by 37
Maternal pre- and postnatal anxiety symptoms and infant attention disengagement from emotional faces
Kataja, E.-L., Karlsson, L., Parsons, C. E., Pelto, J., Pesonen, H., Häikiö, T., Hyönä, J., Nolvi, S., Korja, R., & Karlsson, H. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.09.064 · Cited by 36
The potential of epigenetics in stress-enhanced fear learning models of PTSDPreprint
Blouin, A. M., Sillivan, S. E., Joseph, N. F., & Miller, C. A. (2016) · Learning & Memory · doi:10.1101/lm.040485.115 · Cited by 37
Majcher‐Maślanka, I., Solarz, A., Wędzony, K., & Chocyk, A. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.03.038 · Cited by 35
Pallier, P. N., Ferrara, M., Romagnolo, F., Ferretti, M. T., Soreq, H., & Cerase, A. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102353 · Cited by 37
Cramer, T., Kisliouk, T., Yeshurun, S., & Meiri, N. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22252 · Cited by 35
Daskalakis, N. P., Diamantopoulou, A., Claessens, S. E. F., Remmers, E., Tjälve, M., Oitzl, M. S., Champagne, D. L., & de Kloet, E. R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.021 · Cited by 36
Self-citationTielbeek, J. J., Al-Itejawi, Z., Zijlmans, J., Polderman, T. J. C., Buckholtz, J. W., & Popma, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.009 · Cited by 36
Walther, A., Rice, T., Kufert, Y., & Ehlert, U. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00206 · Cited by 34
The Epigenetics of Early Life Adversity: Current Limitations and Possible Solutions
Barnett-Burns, S., Almeida, D. M., & Turecki, G. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.01.008 · Cited by 35
Omics Insights into Animal Resilience and Stress Factors
Basile, F., Capaccia, C., Zampini, D., Biagetti, T., Diverio, S., & Guelfi, G. (2020) · Animals · doi:10.3390/ani11010047 · Cited by 39
Parental effects alter the adaptive value of an adult behavioural trait
Kilner, R. M., Boncoraglio, G. P., Henshaw, J. M., Jarrett, B. J. M., Gasperin, O. D., Attisano, A., & Kokko, H. (2015) · eLife · doi:10.7554/elife.07340 · Cited by 33
Goh, J.-Y., O’Sullivan, S. E., Shortall, S. E., Zordan, N., Piccinini, A. M., Potter, H. G., Fone, K. C. F., & King, M. V. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.05.076 · Cited by 33
Starr, L. R., Stroud, C. B., Shaw, Z. A., & Vrshek‐Schallhorn, S. (2020) · Development and Psychopathology · doi:10.1017/s0954579420000474 · Cited by 36
Korja, R., Nolvi, S., Scheinin, N. M., Tervahartiala, K., Carter, A. S., Karlsson, H., Kataja, E., & Karlsson, L. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.12.076 · Cited by 38
Margolis, E. T., & Gabard-Durnam, L. J. (2024) · Infancy · doi:10.1111/infa.12588 · Cited by 34
DNA methylation and the social gradient of osteoporotic fracture: A conceptual model
Brennan-Olsen, S. L., Page, R. S., Berk, M., Riancho, J. A., Leslie, W. D., Wilson, S. G., Saban, K. L., Janusek, L. W., Pasco, J. A., Hodge, J. M., et al. (2015) · Bone · doi:10.1016/j.bone.2015.12.015 · Cited by 32
Boeck, C., Salinas-Manrique, J., Calzia, E., Radermacher, P., Arnim, C. A. F. V., Dietrich, D. E., Kolassa, I., & Karabatsiakis, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-26867-7 · Cited by 32
Gross, M., Romi, H., Miller, A., & Pinhasov, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-27988-9 · Cited by 32
Stability and change: Stress responses and the shaping of behavioral phenotypes over the life span
Hennessy, M. B., Kaiser, S., Tiedtke, T., & Sachser, N. (2015) · Frontiers in Zoology · doi:10.1186/1742-9994-12-s1-s18 · Cited by 32
Seiler, A., Milliken, A. B., Leiter, R. E., Blum, D., & Slavich, G. M. (2024) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2024.100226 · Cited by 36
Early-life social adversity and developmental processes in nonhuman primates
French, J. A., & Carp, S. B. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.11.004 · Cited by 34
Buffington, C. A. T., & Bain, M. J. (2020) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2020.03.001 · Cited by 32
Zhang, B. (2017) · PubMed Central · doi:10.13918/j.issn.2095-8137.2017.002 · Cited by 32
Koenig, A. M., Ramo‐Fernández, L., Boeck, C., Umlauft, M., Pauly, M., Binder, E. B., Kirschbaum, C., Gündel, H., Karabatsiakis, A., & Kolassa, I. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.04.002 · Cited by 31
The Development of Stress Reactivity and Regulation in Children and Adolescents
Filetti, C. R., Kane‐Grade, F., & Gunnar, M. R. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230808120504 · Cited by 32
Principles for developing animal models of military PTSD
Daskalakis, N. P., & Yehuda, R. (2014) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v5.23825 · Cited by 32
Self-citationHaller, J. (2018) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2018.00026 · Cited by 33
Mihaljevic, M. M., Zeljić, K., Soldatović, I., Petrović, S. A., Mirjanić, T., Richards, A. L., Mantripragada, K. K., Pekmezovic, T. D., Novaković, I. V., & Marić, N. P. (2016) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-016-0720-7 · Cited by 30
Reconsolidation and extinction: Using epigenetic signatures to challenge conventional wisdom
Hemstedt, T. J., Lattal, K. M., & Wood, M. A. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.01.007 · Cited by 30
Pereira, N. D. S. C., Lampert, C., Vieira, A. D. S., Lazzaretti, C., Kincheski, G. C., Espejo, P. J., Molina, V. A., Quillfeldt, J. A., & Dalmaz, C. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00134 · Cited by 31
Bonapersona, V., Damsteegt, R., Adams, M. L., van Weert, L. T. C. M., Meijer, O. C., Joëls, M., & Sarabdjitsingh, R. A. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00181 · Cited by 32
Mancini, G. F., Marchetta, E., Pignani, I., Trezza, V., & Campolongo, P. (2021) · Cells · doi:10.3390/cells10020360 · Cited by 33
Captivity-Induced Depression in Animals
Lecorps, B., Weary, D. M., & von Keyserlingk, M. A. G. (2021) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2021.03.010 · Cited by 29
Mancini, G. F., Meijer, O. C., & Campolongo, P. (2023) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2023.101065 · Cited by 33
Mposhi, A., & Turner, J. D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1215544 · Cited by 30
The stress concept in gastroenterology: from Selye to today
Elsenbruch, S., & Enck, P. (2017) · F1000Research · doi:10.12688/f1000research.12435.1 · Cited by 31
The Developmental Origins of Opioid Use Disorder and Its Comorbidities
Levis, S. C., Mahler, S. V., & Baram, T. Z. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.601905 · Cited by 33
Verstraeten, B. S. E., McCreary, J. K., Weyers, S., Metz, G. A. S., & Olson, D. M. (2019) · Biology of Reproduction · doi:10.1093/biolre/ioy166 · Cited by 28
Neural underpinnings of fine motor skills under stress and anxiety: A review
Martins, L. A., Schiavo, A., Paz, L. V., Xavier, L. L., & Mestriner, R. G. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114593 · Cited by 30
Strzelewicz, A. R., Sanchez, E. O., Rondón-Ortiz, A. N., Raneri, A., Famularo, S. T., Bangasser, D. A., & Kentner, A. C. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.01.003 · Cited by 29
Oswald, L. M., Dunn, K. E., Seminowicz, D. A., & Storr, C. L. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11040315 · Cited by 29
Köhler, J. C., Gröger, N., Lesse, A., Guara Ciurana, S., Rether, K., Fegert, J., Bock, J., & Braun, K. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1199-1 · Cited by 28
Inflammation as a Mechanism of Bipolar Disorder Neuroprogression
Barichello, T., Giridharan, V. V., Bhatti, G. S., Sayana, P., Doifode, T., Macêdo, D. S., & Quevedo, J. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_173 · Cited by 28
Long term effects of early life stress on HPA circuit in rodent models
Babicola, L., Ventura, R., D’Addario, S. L., Ielpo, D., Andolina, D., & Segni, M. D. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111125 · Cited by 31
Is early life adversity a trigger towards inflammageing?
Merz, M. P., & Turner, J. D. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111377 · Cited by 29
Lizárraga, D., & Garcı́a-Gasca, A. (2021) · Epigenomes · doi:10.3390/epigenomes5020013 · Cited by 27
McKibben, L. A., & Dwivedi, Y. (2021) · BMC Genomics · doi:10.1186/s12864-021-08003-4 · Cited by 28
Impact of Enrichment and Repeated Mixing on Resilience in Pigs
Luo, L., van der Zande, L. E., van Marwijk, M. A., Knol, E. F., Rodenburg, T. B., Bolhuis, J. E., & Parois, S. P. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.829060 · Cited by 27
Prusator, D. K., Andrews, A., & Meerveld, B. G. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12862 · Cited by 27
Campus, P., Canterini, S., Orsini, C., Fiorenza, M. T., Puglisi‐Allegra, S., & Cabib, S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00621 · Cited by 28
Nees, F., Witt, S. H., & Flor, H. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.12.015 · Cited by 28
Metadata
- Authors
- Daskalakis, N. P., Bagot, R. C., Parker, K. J., Vinkers, C. H., & de Kloet, E. R.
- Affiliations
- Leiden University (NL)
- Douglas Mental Health University Institute (CA)
- Stanford Medicine (US)
- Utrecht University (NL)
- Corresponding author
- Daskalakis, Nikolaos P.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 38
- Issue
- 9
- Pages
- 1858-1873
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC3773020
- OpenAlex
- W2150581383
- Semantic Scholar
- 803eaa44fe6fdff1f9eccd7886ac5a72114899e7
- Cited by
- 579
- References
- 202
- Citations by year
- 2026: 34 · 2025: 29 · 2024: 62 · 2023: 49 · 2022: 52 · 2021: 58 · 2020: 54 · 2019: 50 · 2018: 45 · 2017: 44 · 2016: 41 · 2015: 34 · 2014: 22 · 2013: 4
- FWCI
- 14.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Funders
- Dutch Top-Institute Pharma T5-209
- NIH-R01HD67175
- Royal Netherlands Academy for Sciences
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- vulnerability and resilience, childhood adversity, stress-related disorders, gene-environment interaction, match-mismatch hypothesis, coping
- MeSH terms
- Adaptation, Psychological, Animals, Avoidance Learning, Disease Models, Animal, Female, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Maternal Behavior, Maternal Deprivation, Models, Neurological, Models, Psychological, Neuronal Plasticity, Pituitary-Adrenal System, Pregnancy, Prenatal Exposure Delayed Effects, Primates, Stress Disorders, Post-Traumatic, Stress, Psychological, Genetic Predisposition to Disease, Vulnerable Populations, Epigenesis, Genetic, Rats, Resilience, Psychological, Gene-Environment Interaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
