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Cited by 28Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorChild Abuse and Trauma

Early-Life Adversity Induces Epigenetically Regulated Changes in Hippocampal Dopaminergic Molecular Pathways

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Köhler, Jana C., Gröger, N., Lesse, A., Guara Ciurana, S., Rether, K., Fegert, J., Bock, J., Braun, Katharina·2019·Molecular Neurobiology
DOI 10.1007/s12035-018-1199-1PMC PMC6476847
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Abstract

Early-life adversity (ELA) represents a major risk factor for the development of behavioral dysfunctions and mental disorders later in life. On the other hand, dependent on type, time point, and duration, ELA exposure can also induce adaptations, which result in better stress coping and resilience later in life. Guided by the hypothesis that chronic exposure to ELA results in dysfunctional brain and behavior, whereas short exposure to ELA may result in resilience, the behavioral and neurobiological consequences of long-term separation stress (LTSS) and short-term separation stress (STSS) were compared in a mouse model for ELA. In line with our hypothesis, we found that LTSS induced depressive-like behavior, whereas STSS reduced depressive-like behavioral symptoms. We then tested the hypothesis that the opposite behavioral outcomes of the two stress paradigms may be mediated by functional, epigenetically regulated changes of dopaminergic modulation in the hippocampal formation. We found that STSS exposure elevated dopamine receptor D1 (DRD1) gene expression and decreased gene expression of its downstream modulator DARPP-32 (32-kDa dopamine- and cAMP-regulated phosphoprotein), which was paralleled by decreased H3 acetylation at its gene promoter region. In contrast, LTSS elevated DARPP-32 gene expression, which was not paralleled by changes in histone acetylation and DRD1 gene expression. These findings indicate that short- and long-term neonatal exposure to ELA induces changes in dopaminergic molecular pathways, some of which are epigenetically regulated and which either alleviate or aggravate depressive-like symptoms later in life.

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Authors
Köhler, J. C., Gröger, N., Lesse, A., Guara Ciurana, S., Rether, K., Fegert, J., Bock, J., & Braun, K.
Affiliations
  • Otto-von-Guericke-Universität Magdeburg (DE)
  • University Hospital Ulm (DE)
  • Center for Behavioral Brain Sciences (DE)
Corresponding author
Braun, Katharina
ORCID
Venue
Molecular Neurobiology
Publisher
Springer Science and Business Media LLC
Published
2018-09-01
Volume
56
Issue
5
Pages
3616-3625
ISSN
  • 0893-7648 (ISSN-L)
  • 1559-1182
DOI
10.1007/s12035-018-1199-1
PMC
PMC6476847
OpenAlex
W2889305916
Cited by
28
References
12
Citations by year
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FWCI
1.29
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Neurobiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Bundesministerium für Bildung und Forschung (TRANSGEN 01KR13404B, UBICA 01KR1207D, 01KR1304A)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords
childhood adversity, hippocampus, dopaminergic pathways, dopamine D1 receptor, DARPP-32, histone acetylation, epigenetic regulation, depression-like behavior, resilience, neonatal stress, mouse model
MeSH terms
Acetylation, Animals, Behavior, Animal, Dopamine, Hippocampus, Histones, Immobilization, Mice, Inbred C57BL, Promoter Regions, Genetic, Stress, Psychological, Swimming, Receptors, Dopamine D2, Epigenesis, Genetic, Dopamine and cAMP-Regulated Phosphoprotein 32

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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