The DOI matches its Crossref record; 204 of the 204 references it cites were found in a registry or an index.
The three-hit concept of vulnerability and resilience: Toward understanding adaptation to early-life adversity outcome
Open accessAbstract
Stressful experiences during early-life can modulate the genetic programming of specific brain circuits underlying emotional and cognitive aspects of behavioral adaptation to stressful experiences later in life. Although this programming effect exerted by experience-related factors is an important determinant of mental health, its outcome depends on cognitive inputs and hence the valence an individual assigns to a given environmental context. From this perspective we will highlight, with studies in rodents, non-human primates and humans, the three-hit concept of vulnerability and resilience to stress-related mental disorders, which is based on gene-environment interactions during critical phases of perinatal and juvenile brain development. The three-hit (i.e., hit-1: genetic predisposition, hit-2: early-life environment, and hit-3: later-life environment) concept accommodates the cumulative stress hypothesis stating that in a given context vulnerability is enhanced when failure to cope with adversity accumulates. Alternatively, the concept also points to the individual’s predictive adaptive capacity, which underlies the stress inoculation and match/mismatch hypotheses. The latter hypotheses propose that the experience of relatively mild early-life adversity prepares for the future and promotes resilience to similar challenges in later-life; when a mismatch occurs between early and later-life experience, coping is compromised and vulnerability is enhanced. The three-hit concept is fundamental for understanding how individuals can either be prepared for coping with life to come and remain resilient or are unable to do so and succumb to a stress-related mental disorder, under seemingly identical circumstances.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Accordingly, this shift from a hyper- to a hypo-responsive stress axis in the first 5 years in life may be represent an particularly crucial stress-sensitive period, especially in the absence of a nurturing caregiver (104).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [104]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“After an initial hyper-responsive period, the HPA axis may later transition into a stress hypo-responsive period (SHRP) with lower basal cortisol levels and blunted stress-induced cortisol reactivity (101, 104–106).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [104]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The classical vulnerabilitystress model of mental disorders, arguably one of the most influential models of disorder development, as well as conceptually similar approaches such as the”
From The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention (2020) · cites this paper as Daskalakis, Bagot, Parker, Vinkers, & de Kloet, 2013
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Taken together, enduring changes in the transcriptome may facilitate the response to early developmental challenges and thus play a central role in the long-term (and sometimes transgenerational) biological trajectories of stress-related disease through programming effects for stress reactivity after ELS/CT exposure (104, 413, 414).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [104]
The cited source says what the claim attributes to it.
In the citing paper
“Recently, Daskalakis et al. (104) have expanded this model suggesting a three-hit concept for vulnerability and resilience.”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [104]
The cited source says what the claim attributes to it.
In the citing paper
“Accordingly, vulnerability in a given context is enhanced when failure to cope with adversity accumulates.”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [104]
The cited source says what the claim attributes to it.
In the citing paper
“The interaction of the individual genetic background (hit-1) with ELS/CT exposure (hit-2) results in an evolving phenotype with altered stress axis regulation and sensitivity due to early developmental programming, which, in turn, interacts with later-life challenges (hit-3) to result in a higher or lower vulnerability risk according to the type of challenge experienced.”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [104]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177
Stress, adaptation, and disease. Allostasis and allostatic load
McEWEN, B. S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09546.x · Cited by 5,092
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531
Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170
Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R. (1998) · Endocrine Reviews · doi:10.1210/er.19.3.269 · Cited by 2,614
Self-citationCausal Relationship Between Stressful Life Events and the Onset of Major Depression
Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.837 · Cited by 2,566 · cited 2×
“, events that are directly related to an individual’s own behavior (Kendler et al., 1999).”
Background
Cited by
Sorted by citations
Items 201–300 of 582
von Gontard, A., Vrijens, D., Selai, C. E., Mosiello, G., Panicker, J. N., van Koeveringe, G. A., Apostolidis, A., & Anding, R. (2019) · Neurourology and Urodynamics · doi:10.1002/nau.24016 · Cited by 26
Trujillo, V., Durando, P. E., & Suárez, M. M. (2015) · Stress · doi:10.3109/10253890.2015.1105958 · Cited by 26
Knop, J., Joëls, M., & van der Veen, R. (2017) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2017.02.030 · Cited by 26
Few long-term consequences after prolonged maternal separation in female Wistar rats
Lundberg, S., Abelson, K., Nylander, I., & Roman, E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0190042 · Cited by 26
Trajectory of depressive symptoms over adolescence in autistic and neurotypical youth
Corbett, B. A., Muscatello, R. A., McGonigle, T., Vandekar, S., Burroughs, C., & Sparks, S. (2024) · Molecular Autism · doi:10.1186/s13229-024-00600-w · Cited by 28
A new 3-hit mouse model of schizophrenia built on genetic, early and late factors
Bouët, V., Percelay, S., Leroux, E., Diarra, B., Léger, M., Delcroix, N., Andrieux, A., Dollfus, S., Fréret, T., & Boulouard, M. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.11.043 · Cited by 25
Snyder, K., Barry, M. E., Plona, Z., Ho, A., Zhang, X., & Valentino, R. J. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.047 · Cited by 25
Paul, N. W., Banerjee, M., & Efferth, T. (2015) · Humanities · doi:10.3390/h5010004 · Cited by 24
Childhood trauma and insulin resistance in patients suffering from depressive disorders
Nasca, C., Watson, K. T., Bigio, B., Robakis, T. K., Myoraku, A., Wroolie, T., McEwen, B. S., & Rasgon, N. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.01.005 · Cited by 24
Active behaviour during early development shapes glucocorticoid reactivity
Castillo-Ramírez, L. A., Ryu, S., & Marco, R. J. D. (2019) · Scientific Reports · doi:10.1038/s41598-019-49388-3 · Cited by 24
Mancini, G. F., Torrisi, S. A., Viho, E. M. G., Meijer, O. C., Leggio, G. M., & Campolongo, P. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00732-5 · Cited by 25
Bodden, C., Richter, S. H., Schreiber, R. S., Kloke, V., Gerß, J., Palme, R., Lesch, K., Lewejohann, L., Kaiser, S., & Sachser, N. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00047 · Cited by 25
Effects of Early Life Adversities upon Memory Processes and Cognition in Rodent Models
Alves, J., Pereira, N. D. S. C., de Lima, R. M. S., Quillfeldt, J. A., & Dalmaz, C. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.04.023 · Cited by 26
Demaili, A., Portugalov, A., Dudai, M., Maroun, M., Akirav, I., Braun, K., & Bock, J. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1129946 · Cited by 24
Kasanova, Z., Hernaus, D., Vaessen, T., van Amelsvoort, T., Winz, O., Heinzel, A., Pruessner, J. C., Mottaghy, F. M., Collip, D., & Myin‐Germeys, I. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150746 · Cited by 23
Hostinar, C. E., Swartz, J. R., Alen, N. V., Guyer, A. E., & Hastings, P. D. (2023) · Journal of Psychopathology and Clinical Science · doi:10.1037/abn0000619 · Cited by 25
Stress, Environment and Early Psychosis
Xenaki, L., Dimitrakopoulos, S., Selaković, M., & Stefanis, N. C. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230817153631 · Cited by 23
Perinatal Developmental Origins of Self-Regulation
Henrichs, J., & den Bergh, B. R. H. V. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1236-0_23 · Cited by 22
Can the neural–cortisol association be moderated by experience-induced changes in awareness?
Lau, W. K., Leung, M.-K., Chan, C. C. H., Wong, S. S. Y., & Lee, T. M. C. (2015) · Scientific Reports · doi:10.1038/srep16620 · Cited by 22
Yu, H., Tain, Y., Sheen, J., Tiao, M., Chen, C., Kuo, H., Hung, P., Hsieh, K., & Huang, L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101610 · Cited by 22
Calpe-López, C., Martínez-Caballero, M. Á., García-Pardo, M. P., & Aguilar, M. A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.825522 · Cited by 22
van den Heuvel, M. I., Henrichs, J., Donkers, F. C. L., & den Bergh, B. R. H. V. (2017) · Developmental Science · doi:10.1111/desc.12612 · Cited by 22
McKenna, B. G., Hammen, C., & Brennan, P. A. (2021) · Development and Psychopathology · doi:10.1017/s0954579419001639 · Cited by 21
Epigenetic mechanisms linking early-life adversities and mental health
Cánepa, E. T., & Berardino, B. G. (2024) · Biochemical Journal · doi:10.1042/bcj20230306 · Cited by 22
Sachs, B. D., Rodriguiz, R. M., Tran, H. L., Iyer, A., Wetsel, W. C., & Caron, M. G. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.12.019 · Cited by 21
Benmhammed, H., Hayek, S. E., Nassiri, A., Bousalham, R., Mesfioui, A., Ouichou, A., & Hessni, A. E. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.01.005 · Cited by 21
King, L., Jolicoeur‐Martineau, A., Laplante, D. P., Székely, E., Levitan, R. D., & Wazana, A. D. (2020) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000663 · Cited by 23
Oresta, S., Vinkers, C. H., van Rossum, E. F. C., Penninx, B. W. J. H., & Nawijn, L. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105150 · Cited by 22
Self-citationGrant, K.-A., Sandman, C. A., Wing, D. A., Dmitrieva, J., & Davis, E. P. (2015) · Psychological Science · doi:10.1177/0956797615580299 · Cited by 20
Mechanisms of childhood trauma: an integrative review of a multimodal, transdiagnostic pathway
Pasteuning, J., Broeder, C., Broeders, T. A. A., Busby, R. M., Gathier, A. W., Kuzminskaite, E., Linsen, F., Souama, C., Verhoeven, J. E., Sep, M. S. C., et al. (2025) · Neurobiology of Stress · doi:10.1016/j.ynstr.2025.100737 · Cited by 20
Self-citationPsychological Resilience in Response to Adverse Experiences
Popham, C. M., McEwen, A. F. S., & Pluess, M. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190095888.003.0022 · Cited by 20
Pilleron, S., Guerchet, M., Bandzouzi, B. N., Mbélesso, P., Dartigues, J., Preux, P., Clément, J., & for the EPIDEMCA Group (2015) · Neuroepidemiology · doi:10.1159/000375462 · Cited by 20
Endogenous opioids regulate glucocorticoid-dependent stress-coping strategies in mice
Szklarczyk, K., Korostyński, M., Gołda, S., Piechota, M., Ficek, J., & Przewłocki, R. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.034 · Cited by 20
Segni, M. D., Andolina, D., D’Addario, S. L., Babicola, L., Ielpo, D., Luchetti, A., Pascucci, T., Iacono, L. L., D'Amato, F. R., & Ventura, R. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.06.016 · Cited by 21
Brückmann, R., Tuchscherer, M., Tuchscherer, A., Gimsa, U., & Kanitz, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155212 · Cited by 20
The Neurobiology of Infant Attachment-Trauma and Disruption of Parent–Infant Interactions
Naeem, N., Zanca, R. M., Weinstein, S., Urquieta, A., Sosa, A., Yu, B., & Sullivan, R. M. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.882464 · Cited by 25
Filho, M. O. A., de Freitas, B. S., Garcia, R. C. L., Crivelaro, P. C. D. F., Schröder, N., & de Lima, M. N. M. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.12.054 · Cited by 19
Brain-region-specific Molecular Responses to Maternal Separation and Social Defeat Stress in Mice
Sachs, B. D., Tran, H. L., Folse, E., & Caron, M. G. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.01.018 · Cited by 19
van der Doelen, R. H. A., Robroch, B., Arnoldussen, I. A. C., Schulpen, M., Homberg, J. R., & Kozicz, T. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.10.072 · Cited by 20
Segni, M. D., Andolina, D., Coassin, A., Accoto, A., Luchetti, A., Pascucci, T., Luzi, C., Lizzi, A. R., D'Amato, F. R., & Ventura, R. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.07.014 · Cited by 19
Kirkpatrick, M., Mandal, G., Elhadidy, I., Mariani, N., Priestley, K., Pariante, C. M., & Borsini, A. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02866-1 · Cited by 20
Mental health and suicidal ideation in US military veterans with histories of COVID-19 infection
Na, P. J., Tsai, J., Harpaz‐Rotem, I., & Pietrzak, R. H. (2021) · BMJ Military Health · doi:10.1136/bmjmilitary-2021-001846 · Cited by 18
Azar, N., & Booij, L. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.09.008 · Cited by 23
Cosentino, L., Zidda, F., Dukal, H., Witt, S. H., Filippis, B. D., & Flor, H. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02259-4 · Cited by 18
Daskalakis, N. P., Enthoven, L., Schoonheere, E., de Kloet, E. R., & Oitzl, M. S. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00190 · Cited by 18
Self-citationStress Response and Perinatal Reprogramming: Unraveling (Mal)adaptive Strategies
Musazzi, L., & Marrocco, J. (2016) · Neural Plasticity · doi:10.1155/2016/6752193 · Cited by 18
Liang, Y., Cheng, J., Zhou, Y., & Liu, Z. (2019) · European Journal of Psychotraumatology · doi:10.1080/20008198.2019.1586266 · Cited by 18
Rajkumar, R. P. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.621853 · Cited by 19
McCarty, R. C., Josephs, T., Kovtun, O., & Rosenthal, S. J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01494-5 · Cited by 19
Stressful Newborn Memories: Pre-Conceptual, In Utero, and Postnatal Events
Papadopoulou, Z. L., Vlaikou, A., Theodoridou, D., Markopoulos, G. S., Tsoni, K., Agakidou, E., Drosou‐Agakidou, V., Turck, C. W., Filiou, M. D., & Syrrou, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00220 · Cited by 19
Parvalbumin interneuron activity in autism underlies susceptibility to PTSD-like memory formation
Abed, A. S. A., Allen, T. V., Ahmed, N. Y., Sellami, A., Sontani, Y., Rawlinson, E. C., Marighetto, A., Desmedt, A., & Dehorter, N. (2024) · iScience · doi:10.1016/j.isci.2024.109747 · Cited by 17
Alexithymia and negative emotions among nursing students: a moderated mediation model
Sun, F., Wang, F., Hu, X., Xue, J.-M., Zheng, S., Su, J., & Lu, Q. (2024) · BMC Nursing · doi:10.1186/s12912-024-01832-0 · Cited by 18
Bertollo, A. G., Mingoti, M. E. D., de Medeiros, J., da Silva, G. B., Capoani, G. T., Lindemann, H., Cassol, J. V., Manica, D., de Oliveira, T., Garcez, M. L., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04198-1 · Cited by 18
Gaudi, S., Guffanti, G., Fallon, J., & Macciardi, F. M. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24046 · Cited by 17
Knop, J., van IJzendoorn, M. H., Bakermans‐Kranenburg, M. J., Joëls, M., & van der Veen, R. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.04.001 · Cited by 17
Zhang, W., Ham, J., Li, Q., Deyssenroth, M. A., Lambertini, L., Huang, Y., Tsuchiya, K. J., Chen, J., & Nomura, Y. (2020) · PLoS ONE · doi:10.1371/journal.pone.0226605 · Cited by 19
Contributions of PTSD polygenic risk and environmental stress to suicidality in preadolescents
Daskalakis, N. P., Schultz, L. M., Visoki, E., Moore, T. M., Argabright, S. T., Harnett, N. G., DiDomenico, G. E., Warrier, V., Almasy, L. A., & Barzilay, R. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100411 · Cited by 17
Self-citationKentrop, J., van der Tas, L., Loi, M., van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Joëls, M., & van der Veen, R. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00122 · Cited by 16
Cirulli, F. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.12.009 · Cited by 16
Fuentes, S., Daviu, N., Gagliano, H., Belda, X., Armario, A., & Nadal, R. A. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.05.017 · Cited by 16
Nolvi, S., Bridgett, D. J., Korja, R., Kataja, E., Junttila, N., Karlsson, H., & Karlsson, L. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.07.055 · Cited by 16
Tripathi, K. K., Demiray, Y. E., Kliche, S., Jing, L., Hazra, S., Hazra, J. D., Richter‐Levin, G., & Stork, O. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100350 · Cited by 16
Trauma history as a resilience factor for patients recovering from total knee replacement surgery
Cremeans‐Smith, J. K., Greene, K. A., & Delahanty, D. L. (2014) · Psychology and Health · doi:10.1080/08870446.2014.1001391 · Cited by 16
Panicker, J. N., Selai, C. E., Hervé, F., Rademakers, K. L. J., Dmochowski, R. R., Tarcan, T., von Gontard, A., & Vrijens, D. (2019) · Neurourology and Urodynamics · doi:10.1002/nau.24233 · Cited by 16
Tang, A., Wade, M., Fox, N. A., Nelson, C. A., Zeanah, C. H., & Slopen, N. B. (2020) · Development and Psychopathology · doi:10.1017/s0954579420001479 · Cited by 16
Meditation for stress and anxiety relief in undergraduate students: a randomized clinical trial
Malheiros, P. C., Vanderlei, A. D., & de Brum, E. H. M. (2023) · Revista Brasileira de Educação Médica · doi:10.1590/1981-5271v47.1-20220021 · Cited by 15
Skånberg, L., Newberry, R. C., Estévez, I., & Keeling, L. J. (2023) · Scientific Reports · doi:10.1038/s41598-023-33212-0 · Cited by 15
den Bergh, B. R. H. V., Antonelli, M. C., & Stein, D. J. (2024) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000932 · Cited by 16
Gao, Y., Liu, J., Liu, X., Wang, Y., & Qiu, S. (2024) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2024.106804 · Cited by 15
Vasopressin and post-traumatic stress disorder
Sipos, E., Török, B., Barna, I., Engelmann, M., & Zelena, D. (2020) · Stress · doi:10.1080/10253890.2020.1826430 · Cited by 15
Palser, E. R., Morris, N., Roy, A. R. K., Holley, S. R., Veziris, C. R., Watson, C., Deleon, J., Miller, Z., Miller, B. L., Gorno‐Tempini, M. L., et al. (2021) · Biological Psychology · doi:10.1016/j.biopsycho.2021.108203 · Cited by 20
Kafetsios, K. G. (2021) · Social Psychological and Personality Science · doi:10.1177/19485506211053461 · Cited by 15
Nazar, F. N., Skånberg, L., McCrea, K., & Keeling, L. J. (2022) · Animals · doi:10.3390/ani12151969 · Cited by 15
Prophylactic action of ayahuasca in a non-human primate model of depressive-like behavior
Grilo, M. L. P. D. M., de Sousa, G. M., de Mendonça, L. A. C., Soares, B. L., de Sousa, M. B. C., Palhano-Fontes, F., de Araújo, D. B., Perkins, D., Hallak, J. E. C., & Coelho, N. L. G. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.901425 · Cited by 16
Coping with the multifaceted and multifunctional role of cortisol in the brain
de Kloet, E. R. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.104047 · Cited by 18
Wang, R., Chen, Y.-F., Chen, S. X., Hao, B., Li, X., Wang, X., Shi, Y., & Zhao, H. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy078 · Cited by 14
Berry, A., Mazzelli, M., Musillo, C., Riva, M. A., Cattaneo, A., & Cirulli, F. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15181 · Cited by 14
D’Addario, S. L., Segni, M. D., Ledonne, A., Piscitelli, R. M., Babicola, L., Martini, A., Spoleti, E., Mancini, C., Ielpo, D., D'Amato, F. R., et al. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100324 · Cited by 16
Matas, E., Bock, J., & Braun, K. (2016) · Psychopathology · doi:10.1159/000448055 · Cited by 14
An allostatic epigenetic memory on chromatin footprints after double-hit acute stress
Caradonna, S. G., Paul, M. R., & Marrocco, J. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100475 · Cited by 13
Atkinson, L., Doyle, R. E., Woodward, A. P., & Jongman, E. C. (2022) · Behavioural Processes · doi:10.1016/j.beproc.2022.104709 · Cited by 13
Floating Rodents and Stress-Coping Neurobiology
de Kloet, E. R., & Molendijk, M. L. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.04.003 · Cited by 14
Fontana, B. D., Cleal, M., Norton, W., & Parker, M. O. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113526 · Cited by 13
Ionic Channels as Potential Targets for the Treatment of Autism Spectrum Disorder: A Review
da Silva, B. A., da Silva, P. R., Gonzaga, T. K. S. D. N., & Maia, R. E. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210809102547 · Cited by 13
Developmental Programming, Evolution, and Animal Welfare: A Case for Evolutionary Veterinary Science
Veit, W., & Browning, H. (2021) · Journal of Applied Animal Welfare Science · doi:10.1080/10888705.2021.2014838 · Cited by 13
Schuler, H., Bonapersona, V., Joëls, M., & Sarabdjitsingh, R. A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0253406 · Cited by 15
Baugher, B. J., & Sachs, B. D. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.941884 · Cited by 15
Gaszner, T., Farkas, J. I., Kun, D., Ujvari, B., Berta, G., CSERNUS, V. J., Füredi, N., Kovács, L. Á., Hashimoto, H., Reglődi, D., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.995900 · Cited by 14
Vasopressin as Possible Treatment Option in Autism Spectrum Disorder
László, K., Vörös, D., Correia, P., Fazekas, C. L., Török, B., Plangár, I., & Zelena, D. (2023) · Biomedicines · doi:10.3390/biomedicines11102603 · Cited by 13
Pre-reproductive Parental Enriching Experiences Influence Progeny’s Developmental Trajectories
Cutuli, D., Berretta, E., Laricchiuta, D., Caporali, P., Gelfo, F., & Petrosini, L. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00254 · Cited by 13
Photobiomodulation rescues cognitive flexibility in early stressed subjects
Banqueri, M., Martínez, J. A., Prieto, M. J., Cid-Duarte, S., Méndez, M., & Arias, J. L. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146300 · Cited by 13
Genetics and epigenetics of stress: New avenues for an old concept
Estruch, M. S., Tamashiro, K. L., & Daskalakis, N. P. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100525 · Cited by 13
Self-citationAge-related physiological dysregulation progresses slowly in semi-free-ranging chimpanzees
Cole, M. F., Barnes, P., Monroe, I. G., Rukundo, J., Thompson, M. E., & Rosati, A. G. (2024) · Evolution Medicine and Public Health · doi:10.1093/emph/eoae010 · Cited by 12
Validation of the Assessment of Parent and Child Adversity (APCA) in Mothers and Young Children
King, L. S., Humphreys, K. L., Shaw, G. M., Stevenson, D. K., & Gotlib, I. H. (2022) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2022.2042696 · Cited by 12
Lopes, N. A., Ambeskovic, M., King, S. E., Faraji, J., Soltanpour, N., Falkenberg, E. A., Scheidl, T. B., Patel, M. M., Fang, X., Metz, G. A. S., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043734 · Cited by 12
Yu, S., Zhao, Y., Luo, Q., Gu, B., Wang, X., Cheng, J., Wang, Z., Liu, D., Ho, R., & Ho, C. S. H. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.12.030 · Cited by 12
Iacono, L. L., Mancini, C., Babicola, L., Pietrosanto, M., Segni, M. D., D’Addario, S. L., Municchi, D., Ielpo, D., Pascucci, T., Cabib, S., et al. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100406 · Cited by 13
Cabib, S., Latagliata, E. C., & Orsini, C. (2022) · Brain Sciences · doi:10.3390/brainsci12020246 · Cited by 12
Spiliopoulos, O. M., Brown, C., Hilder, P. E., Tilbrook, A. J., & Descovich, K. (2025) · Reviews in Aquaculture · doi:10.1111/raq.70051 · Cited by 11
The Impact of Stress Within and Across Generations: Neuroscientific and Epigenetic Considerations
Miller, C. W. T. (2021) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000300 · Cited by 13
Metadata
- Authors
- Daskalakis, N. P., Bagot, R. C., Parker, K. J., Vinkers, C. H., & de Kloet, E. R.
- Affiliations
- Leiden University (NL)
- Douglas Mental Health University Institute (CA)
- Stanford Medicine (US)
- Utrecht University (NL)
- Corresponding author
- Daskalakis, Nikolaos P.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 38
- Issue
- 9
- Pages
- 1858-1873
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC3773020
- OpenAlex
- W2150581383
- Semantic Scholar
- 803eaa44fe6fdff1f9eccd7886ac5a72114899e7
- Cited by
- 579
- References
- 202
- Citations by year
- 2026: 34 · 2025: 29 · 2024: 62 · 2023: 49 · 2022: 52 · 2021: 58 · 2020: 54 · 2019: 50 · 2018: 45 · 2017: 44 · 2016: 41 · 2015: 34 · 2014: 22 · 2013: 4
- FWCI
- 14.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Funders
- Dutch Top-Institute Pharma T5-209
- NIH-R01HD67175
- Royal Netherlands Academy for Sciences
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- vulnerability and resilience, childhood adversity, stress-related disorders, gene-environment interaction, match-mismatch hypothesis, coping
- MeSH terms
- Adaptation, Psychological, Animals, Avoidance Learning, Disease Models, Animal, Female, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Maternal Behavior, Maternal Deprivation, Models, Neurological, Models, Psychological, Neuronal Plasticity, Pituitary-Adrenal System, Pregnancy, Prenatal Exposure Delayed Effects, Primates, Stress Disorders, Post-Traumatic, Stress, Psychological, Genetic Predisposition to Disease, Vulnerable Populations, Epigenesis, Genetic, Rats, Resilience, Psychological, Gene-Environment Interaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
