Cited by 66Posttraumatic Stress Disorder ResearchStress Responses and CortisolT-cell and B-cell Immunology

PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit

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Aiello, Allison E., Dowd, Jennifer B., Jayabalasingham, Bamini, Feinstein, Lydia, Uddin, Monica, Simanek, Amanda M., Cheng, Caroline K., Galea, Sandro +3 more·2016·Psychoneuroendocrinology

Abstract

Background Psychosocial stress is thought to play a key role in the acceleration of immunological aging. This study investigated the relationship between lifetime and past-year history of post-traumatic stress disorder (PTSD) and the distribution of T cell phenotypes thought to be characteristic of immunological aging.Methods Data were from 85 individuals who participated in the community-based Detroit Neighborhood Health Study. Immune markers assessed included the CD4:CD8 ratio, the ratio of late-differentiated effector (CCR7-CD45RA+CD27-CD28-) to naïve (CCR7+CD45RA+CD27+CD28+) T cells, the percentage of KLRG1-expressing cells, and the percentage of CD57-expressing cells.Results In models adjusted for age, gender, race/ethnicity, education, smoking status, and medication use, we found that past-year PTSD was associated with statistically significant differences in the CD8+ T cell population, including a higher ratio of late-differentiated effector to naïve T cells, a higher percentage of KLRG1+ cells, and a higher percentage of CD57+ cells. The percentage of CD57+ cells in the CD4 subset was also significantly higher and the CD4:CD8 ratio significantly lower among individuals who had experienced past-year PTSD. Lifetime PTSD was also associated with differences in several parameters of immune aging.Conclusions PTSD is associated with an aged immune phenotype and should be evaluated as a potential catalyzer of accelerated immunological aging in future studies.

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Authors
Aiello, A. E., Dowd, J. B., Jayabalasingham, B., Feinstein, L., Uddin, M., Simanek, A. M., Cheng, C. K., Galea, S., Wildman, D. E., Koenen, K., & Pawelec, G.
Affiliations
  • University of North Carolina at Chapel Hill (US)
  • City University of New York (US)
  • University of Illinois Urbana-Champaign (US)
  • University of Wisconsin–Milwaukee (US)
  • University of Michigan (US)
  • Boston University (US)
  • Harvard University (US)
  • University of Tübingen (DE)
Corresponding author
Aiello, Allison E.
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2016-05
Volume
67
Pages
133-141
ISSN
0306-4530 (ISSN-L)
OpenAlex
W2253484288
Cited by
66
References
50
Citations by year
2026: 9 · 2025: 13 · 2024: 8 · 2023: 3 · 2022: 10 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 2
FWCI
5.35
Type
journal article
Language
en
Open access
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (DA22720, DA022720-S1, RC1MH088283)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
post-traumatic stress disorder, immunological aging, T cell phenotype, CD4/CD8 ratio, naive T cells, psychosocial stress
MeSH terms
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Phenotype, Stress Disorders, Post-Traumatic, Immunophenotyping, T-Lymphocyte Subsets, Cellular Senescence, Young Adult

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