Four functionally distinct populations of human effector-memory CD8+ T lymphocytes

Romero, Pedro; Zippelius, Alfred; Kurth, Isabel; Pittet, Mikaël J; Touvrey, Cédric; Iancu, Emanuela M; Corthesy, Patricia; Devevre, Estelle; Speiser, Daniel E; Rufer, Nathalie

doi:10.4049/jimmunol.178.7.4112

Cited by 405T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesPsoriasis: Treatment and Pathogenesis

Four functionally distinct populations of human effector-memory CD8+ T lymphocytes

Romero, Pedro, Zippelius, Alfred, Kurth, Isabel, Pittet, Mikaël J, Touvrey, Cédric, Iancu, Emanuela M, Corthesy, Patricia, Devevre, Estelle +2 more·2007·The Journal of Immunology

DOI 10.4049/jimmunol.178.7.4112

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Abstract

In humans, the pathways of memory and effector T cell differentiation remain poorly defined. We have dissected the functional properties of ex vivo effector-memory (EM) CD45RA−CCR7− T lymphocytes present within the circulating CD8+ T cell pool of healthy individuals. Our studies show that EM T cells are heterogeneous and are subdivided based on differential CD27 and CD28 expression into four subsets. EM1 (CD27+CD28+) and EM4 (CD27−CD28+) T cells express low levels of effector mediators such as granzyme B and perforin and high levels of CD127/IL-7Rα. EM1 cells also have a relatively short replicative history and display strong ex vivo telomerase activity. Therefore, these cells are closely related to central-memory (CD45RA−CCR7+) cells. In contrast, EM2 (CD27+CD28−) and EM3 (CD27−CD28−) cells express mediators characteristic of effector cells, whereby EM3 cells display stronger ex vivo cytolytic activity and have experienced larger numbers of cell divisions, thus resembling differentiated effector (CD45RA+CCR7−) cells. These data indicate that progressive up-regulation of cytolytic activity and stepwise loss of CCR7, CD28, and CD27 both characterize CD8+ T cell differentiation. Finally, memory CD8+ T cells not only include central-memory cells but also EM1 cells, which differ in CCR7 expression and may therefore confer memory functions in lymphoid and peripheral tissues, respectively.

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CCR7 directs homing to secondary lymphoid tissues.
“As CCR7 promotes homing to secondary lymphoid tissues, EM1 may represent memory T cells that can survey blood and peripheral tissues, whereas CM can home efficiently to lymphoid tissues (Romero et al., 2007).”
From Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination (2021) · cites this paper as Romero et al., 2007

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Authors: Romero, P., Zippelius, A., Kurth, I., Pittet, M. J., Touvrey, C., Iancu, E. M., Corthesy, P., Devevre, E., Speiser, D. E., & Rufer, N.
Affiliations: Ludwig Cancer Research (BE)
Columbia University Irving Medical Center (US)
Division of Clinical Onco-Immunology, Ludwig Institute for Cancer Research, Lausanne Branch, University Hospital of Lausanne , Lausanne ,
Swiss Institute for Experimental Cancer Research , Epalinges ,
Corresponding author: Romero, Pedro
Zippelius, Alfred
ORCID: Romero, Pedro
Zippelius, Alfred
Kurth, Isabel
Iancu, Emanuela M
Speiser, Daniel E
Rufer, Nathalie
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2007-04-01
Volume: 178
Issue: 7
Pages: 4112-4119
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.178.7.4112
OpenAlex: W1577972394
Cited by: 405
References: 43
Citations by year: 2026: 12 · 2025: 14 · 2024: 15 · 2023: 21 · 2022: 24 · 2021: 24 · 2020: 17 · 2019: 16 · 2018: 15 · 2017: 17 · 2016: 13 · 2015: 18 · 2014: 23 · 2013: 21 · 2012: 24
FWCI: 12.03
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (publishedVersion)
HAL (submittedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: CD8+ effector memory T cells, CD8+ T cell differentiation, CD27, CD28, CCR7, granzyme B, perforin, telomerase activity, cytolytic activity, central memory T cells, T cell heterogeneity, T cell memory subsets
MeSH terms: Adult, Aged, Cell Differentiation, Female, Flow Cytometry, Humans, Immunologic Memory, Male, Membrane Glycoproteins, Middle Aged, Receptors, Antigen, T-Cell, RNA, Messenger, T-Lymphocyte Subsets, Telomere, CD28 Antigens, Tumor Necrosis Factor Receptor Superfamily, Member 7, CD8-Positive T-Lymphocytes, Receptors, Chemokine, Receptors, Interleukin-7, Gene Expression Profiling, Pore Forming Cytotoxic Proteins, Interleukin-7 Receptor alpha Subunit, Granzymes, Perforin, Receptors, CCR6

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Four functionally distinct populations of human effector-memory CD8+ T lymphocytes

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