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Polycystic ovary syndrome and psychiatric disorders: Co-morbidity and heritability in a nationwide Swedish cohort
Abstract
Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting 5-15% of reproductive-aged women and characterized by high levels of circulating androgens. Given that androgens have been implicated in the aetiology of several psychiatric disorders, it was hypothesized that women with PCOS have high risk for psychiatric comorbidity. We aimed to investigate this risk amongst women with PCOS, as well as in their siblings, to elucidate if familial factors underlie any potential associations. Using the Swedish national registers, we identified all women diagnosed with PCOS between 1990 and 2013 (n=24,385), their full-siblings (n=25,921), plus matched individuals (1:10/100) from the general population and their full-siblings. Psychiatric disorder diagnoses were identified including schizophrenia, bipolar disorder, depressive and anxiety disorders, eating disorders, personality and gender identity disorder, autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), tics, attempted and completed suicide. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression and adjusted ORs (AOR) were determined by adjustment for comorbid psychiatric disorders. Overall, women with PCOS had an increased odds of having at least one psychiatric disorder (OR=1.56 [95CI%, 1.51-1.61]). Crude ORs showed associations with nearly all psychiatric disorders included in this study. Following adjustment for comorbid psychiatric disorders, women with PCOS were still at a significantly increased risk for bulimia, schizophrenia, bipolar disorder, depressive and anxiety disorders, personality disorders, with the highest AORs for ASD (AOR=1.55 [95%CI, 1.32-1.81]) and tics (AOR=1.65 [95%CI, 1.10-2.47]). Significantly higher AORs were found for ASD in both brothers and sisters of women with PCOS, and for depressive, anxiety, and schizophrenia spectrum disorders in the sisters only. Notably, the crude ORs for attempted suicide were 40% higher in women with PCOS and 16% higher in their unaffected sisters. However, the AORs were greatly attenuated indicating that underlying psychiatric comorbidity is important for this association. Women with PCOS had higher risks for a range of psychiatric disorders not shown before. Elevated risk in their siblings suggests shared familial factors between PCOS and psychiatric disorders. This study is an important first step towards identifying the underlying mechanisms for risk of psychiatric disorders in women with PCOS. Health professionals treating women with PCOS should be aware that these patients - as well as their family members - are important targets for mental health care.
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“Our data showed that mental health and psychiatric disorders had a 30% higher prevalence in those with PCOS, consistent with findings of previous population cohort studies.6,29,31,32,126,127”
From Increased Prevalence of Adverse Health Outcomes Across the Lifespan in Those Affected by Polycystic Ovary Syndrome: A Canadian Population Cohort (2024) · cites this paper as [127]
In the citing paper
“In particular, the prevalence of depression and anxiety in those with PCOS has been reported to be markedly elevated, with a 30%-50% prevalence and an odds ratio of 1.4 to > 2.5 in those with PCOS.7,29,32,127,128”
From Increased Prevalence of Adverse Health Outcomes Across the Lifespan in Those Affected by Polycystic Ovary Syndrome: A Canadian Population Cohort (2024) · cites this paper as [127]
In the citing paper
“it has been both reported that women with POS themselves have an elevated rate of ASD (OR 1.55, 95% CI 1.32–1.81) [81],”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [81]
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Cooney, L. G., Lee, I., Sammel, M. D., & Dokras, A. (2017) · Human Reproduction · doi:10.1093/humrep/dex044 · Cited by 631
The contribution of environmental exposure to the etiology of autism spectrum disorder
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Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome
Stener‐Victorin, E., Padmanabhan, V., Walters, K. A., Campbell, R. E., Benrick, A., Giacobini, P., Dumesic, D. A., & Abbott, D. H. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa010 · Cited by 391
Adolescent polycystic ovary syndrome according to the international evidence-based guideline
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Dokras, A., Stener-Victorin, E., Yildiz, B. O., Li, R., Ottey, S., Shah, D., Epperson, N., & Teede, H. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.01.038 · Cited by 285
Metadata
- Authors
- Cesta, C. E., Månsson, M., Palm, C., Lichtenstein, P., Iliadou, A. N., & Landén, M.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Cesta, Carolyn E.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 73
- Pages
- 196-203
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2488412037
- Cited by
- 217
- References
- 47
- Citations by year
- 2026: 13 · 2025: 20 · 2024: 25 · 2023: 31 · 2022: 24 · 2021: 24 · 2020: 27 · 2019: 27 · 2018: 8 · 2017: 15 · 2016: 3
- FWCI
- 23.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Swedish Medical Research Council
- EU-FP7 Health program
- Swedish Foundation for Strategic Research
- Strategic Research Program in Epidemiology Young Scholar Awards, Karolinska Institutet
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- polycystic ovary syndrome, psychiatric comorbidity, heritability, familial aggregation, autism spectrum disorder, schizophrenia, bipolar disorder, depressive disorders, anxiety disorders, bulimia nervosa, personality disorders, gender dysphoria, tics, suicide attempts, androgens, full siblings, women's mental health, women of reproductive age
- MeSH terms
- Adolescent, Adult, Mental Disorders, Female, Humans, Polycystic Ovary Syndrome, Registries, Sweden, Cohort Studies, Comorbidity, Siblings, Young Adult
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