Is endometrial receptivity transcriptomics affected in women with endometriosis? A pilot study
Open accessAbstract
Endometrial receptivity is still questioned today in women with endometriosis. The aim of this study was to assess the endometrial receptivity gene signature in patients with different stages of endometriosis by investigating transcriptomic modifications of their endometrium using the endometrial receptivity array (ERA) test. A prospective, interventional multicentre pilot trial was designed and implemented in two university-affiliated infertility units from Belgium and Spain. Gene expression microarray was used to diagnose the receptivity status by quantifying the expression of 238 specific genes directly related to human endometrial receptivity. Unsupervised hierarchical clustering showed no clustering of samples based on endometriosis stages. Two subgroups of samples clustered together corresponding on the day of the cycle in which the biopsy was taken (day 18 versus days 19-20). None of the 238 genes present in the ERA array were significantly over- or under- expressed in any of different stages of the disease compared with controls. Minimal differences were found when looking at the functional profile, suggesting that the possible effect from a clinical point of view may be meaningless. Endometrial receptivity gene signature during the implantation window does not vary significantly among patients with endometriosis even considering different stages compared with healthy women.
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Endometrial biopsy by pipelle or curette is minimally invasive and can be useful to test endometrial receptivity in infertile women and as a diagnostic tool for endometriosis in an outpatient setting.
“The method of obtaining endometrial sample by either pipelle or curette is minimally invasive; however, aside from minimal discomfort for the patient, biopsy can prove to be a useful not only to test endometrial receptivity in infertile women with or without endometriosis (81), but also as a diagnostic tool for endometriosis in an outpatient setting (82).”
From Biomarkers in endometriosis: Challenges and opportunities (2017) · cites this paper as [81]
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Biomarkers in endometriosis: Challenges and opportunities
Ahn, S. H., Singh, V., & Tayade, C. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.01.009 · Cited by 242 · see citing works
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Naem, A., Krentel, H., Moawad, G., Naem, J., Venezia, R., Etrusco, A., Terzic, S., & Laganà, A. S. (2024) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2024.102500 · Cited by 15 · see citing works
- Authors
- Garcia-Velasco, J. A., Fassbender, A., Ruiz-Alonso, M., Blesa, D., D‘Hooghe, T., & Simon, C.
- Affiliations
- Universitair Ziekenhuis Leuven (BE)
- Universitat de València (ES)
- ORCID
- Blesa, David
- Venue
- Reproductive BioMedicine Online
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 31
- Issue
- 5
- Pages
- 647-654
- ISSN
- 1472-6483 (ISSN-L)
- OpenAlex
- W2128261604
- Cited by
- 70
- References
- 44
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 7 · 2017: 9 · 2016: 8 · 2015: 1
- FWCI
- 9.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Reproductive BioMedicine Online (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- endometrial receptivity, endometriosis, endometrial receptivity array, gene expression signatures, endometriosis stage, implantation window, infertility
- MeSH terms
- Adult, Endometriosis, Endometrium, Female, Humans, Pilot Projects, Prospective Studies, Gene Expression Profiling, Microarray Analysis, Transcriptome
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