Cited by 70Endometriosis Research and TreatmentReproductive System and PregnancyReproductive Biology and Fertility

Is endometrial receptivity transcriptomics affected in women with endometriosis? A pilot study

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Garcia-Velasco, Juan A., Fassbender, Amelie, Ruiz-Alonso, Maria, Blesa, David, D‘Hooghe, Thomas, Simon, Carlos·2015·Reproductive BioMedicine Online

Abstract

Endometrial receptivity is still questioned today in women with endometriosis. The aim of this study was to assess the endometrial receptivity gene signature in patients with different stages of endometriosis by investigating transcriptomic modifications of their endometrium using the endometrial receptivity array (ERA) test. A prospective, interventional multicentre pilot trial was designed and implemented in two university-affiliated infertility units from Belgium and Spain. Gene expression microarray was used to diagnose the receptivity status by quantifying the expression of 238 specific genes directly related to human endometrial receptivity. Unsupervised hierarchical clustering showed no clustering of samples based on endometriosis stages. Two subgroups of samples clustered together corresponding on the day of the cycle in which the biopsy was taken (day 18 versus days 19-20). None of the 238 genes present in the ERA array were significantly over- or under- expressed in any of different stages of the disease compared with controls. Minimal differences were found when looking at the functional profile, suggesting that the possible effect from a clinical point of view may be meaningless. Endometrial receptivity gene signature during the implantation window does not vary significantly among patients with endometriosis even considering different stages compared with healthy women.

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Crossref · 10.1016/j.rbmo.2015.07.014

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  • Endometrial biopsy by pipelle or curette is minimally invasive and can be useful to test endometrial receptivity in infertile women and as a diagnostic tool for endometriosis in an outpatient setting.

    “The method of obtaining endometrial sample by either pipelle or curette is minimally invasive; however, aside from minimal discomfort for the patient, biopsy can prove to be a useful not only to test endometrial receptivity in infertile women with or without endometriosis (81), but also as a diagnostic tool for endometriosis in an outpatient setting (82).”

    From Biomarkers in endometriosis: Challenges and opportunities (2017) · cites this paper as [81]

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Authors
Garcia-Velasco, J. A., Fassbender, A., Ruiz-Alonso, M., Blesa, D., D‘Hooghe, T., & Simon, C.
Affiliations
  • Universitair Ziekenhuis Leuven (BE)
  • Universitat de València (ES)
Venue
Reproductive BioMedicine Online
Publisher
Elsevier BV
Published
2015-11
Volume
31
Issue
5
Pages
647-654
ISSN
1472-6483 (ISSN-L)
OpenAlex
W2128261604
Cited by
70
References
44
Citations by year
2026: 4 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 7 · 2017: 9 · 2016: 8 · 2015: 1
FWCI
9.50
Type
journal article
Language
en
Open access
Locations
  • Reproductive BioMedicine Online (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
endometrial receptivity, endometriosis, endometrial receptivity array, gene expression signatures, endometriosis stage, implantation window, infertility
MeSH terms
Adult, Endometriosis, Endometrium, Female, Humans, Pilot Projects, Prospective Studies, Gene Expression Profiling, Microarray Analysis, Transcriptome

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