Cited by 221

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Physiology of Bone Loss

Clarke, Bart L., Khosla, Sundeep·2010·Radiologic Clinics of North America

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.rcl.2010.02.014

Cites

14 of 14 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 77

  1. Riggs, 2004, A population-based study of age and sex differences in bone volumetric density, size, geometry and structure at different skeletal sites, J Bone Miner Res, 19, 1945, 10.1359/jbmr.040916 · DOI · Paper page
  2. Hanson, 1997, New software toolkits for comprehensive visualization and analysis of three-dimensional multimodal biomedical images, J Digit Imaging, 10, 229, 10.1007/BF03168711 · DOI
  3. Khosla, 2006, Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment, J Bone Miner Res, 21, 124, 10.1359/JBMR.050916 · DOI
  4. Khosla, 2006, Hormonal and biochemical determinants of trabecular microstructure at the ultradistal radius in women and men, J Clin Endocrinol Metab, 91, 885, 10.1210/jc.2005-2065 · DOI
  5. Riggs, 2008, A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men, J Bone Miner Res, 23, 205, 10.1359/jbmr.071020 · DOI
  6. Cummings, 2002, Epidemiology and outcomes of osteoporotic fractures, Lancet, 359, 1761, 10.1016/S0140-6736(02)08657-9 · DOI · Paper page
  7. Tosteson, 2002, Quality of life assessment in osteoporosis: health-status and preference-based measures, Pharmacogenomics, 20, 289
  8. Lindsay, 1976, Long-term prevention of postmenopausal osteoporosis by oestrogen: evidence for an increased bone mass after delayed onset of oestrogen treatment, Lancet, 1, 1038, 10.1016/S0140-6736(76)92217-0 · DOI
  9. Genant, 1982, Quantitative computed tomography of vertebral spongiosa: a sensitive method for detecting early bone loss after oophorectomy, Ann Intern Med, 97, 699, 10.7326/0003-4819-97-5-699 · DOI
  10. Khosla, 1997, Effects of age and estrogen status on serum parathyroid hormone levels and biochemical markers of bone turnover in women: a population-based study, J Clin Endocrinol Metab, 82, 1522
  11. Horton, 1966, Androstenedione and testosterone in ovarian venous and peripheral plasma during ovariectomy for breast cancer, J Clin Endocrinol Metab, 26, 1267, 10.1210/jcem-26-11-1267 · DOI
  12. Khosla, 2005, Relationship of volumetric bone density and structural parameters at different skeletal sites to sex steroid levels in women, J Clin Endocrinol Metab, 90, 5096, 10.1210/jc.2005-0396 · DOI
  13. Perrien, 2006, Bone turnover across the menopause transition: correlations with inhibins and follicle-stimulating hormone, J Clin Endocrinol Metab, 91, 1848, 10.1210/jc.2005-2423 · DOI
  14. Garnero, 1996, Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis, J Bone Miner Res, 11, 337, 10.1002/jbmr.5650110307 · DOI
  15. Young, 1967, Calcium metabolism and the menopause, Proc R Soc Med, 60, 1137
  16. Gennari, 1990, Estrogen preserves a normal intestinal responsiveness to 1,25-dihydroxyvitamin D3 in oophorectomized women, J Clin Endocrinol Metab, 71, 1288, 10.1210/jcem-71-5-1288 · DOI
  17. Riggs, 1998, A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men, J Bone Miner Res, 13, 763, 10.1359/jbmr.1998.13.5.763 · DOI
  18. Lacey, 1998, Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation, Cell, 93, 165, 10.1016/S0092-8674(00)81569-X · DOI · Paper page
  19. Clowes, 2005, The role of the immune system in the pathophysiology of osteoporosis, Immunol Rev, 208, 207, 10.1111/j.0105-2896.2005.00334.x · DOI
  20. Simonet, 1997, Osteoprotegerin: a novel secreted protein involved in the regulation of bone density, Cell, 89, 309, 10.1016/S0092-8674(00)80209-3 · DOI · Paper page
  21. Charatcharoenwitthaya, 2007, Effect of blockade of TNF-alpha and interleukin-1 action on bone resorption in early postmenopausal women, J Bone Miner Res, 22, 724, 10.1359/jbmr.070207 · DOI
  22. Manolagas, 1995, Bone marrow, cytokines, and bone remodeling: emerging insights into the pathophysiology of osteoporosis, N Engl J Med, 332, 305, 10.1056/NEJM199502023320506 · DOI
  23. Pacifici, 1991, Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells, Proc Natl Acad Sci U S A, 88, 5134, 10.1073/pnas.88.12.5134 · DOI · Paper page
  24. Tanaka, 1993, Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors, J Clin Invest, 91, 257, 10.1172/JCI116179 · DOI
  25. Kimble, 1994, Interleukin-1 receptor antagonist decreased bone loss and bone resorption in ovariectomized rats, J Clin Invest, 93, 1959, 10.1172/JCI117187 · DOI
  26. Ammann, 1997, Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency, J Clin Invest, 99, 1699, 10.1172/JCI119333 · DOI · Paper page
  27. Kimble, 1996, Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an interleukin-1- and tumor necrosis factor-mediated stimulation of macrophage colony-stimulating factor production, J Biol Chem, 271, 28890, 10.1074/jbc.271.46.28890 · DOI
  28. Kitazawa, 1994, Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice, J Clin Invest, 94, 2397, 10.1172/JCI117606 · DOI
  29. Girasole, 1992, 17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens, J Clin Invest, 89, 883, 10.1172/JCI115668 · DOI
  30. Jilka, 1992, Increased osteoclast development after estrogen loss: mediation by interleukin-6, Science, 257, 88, 10.1126/science.1621100 · DOI
  31. Oursler, 1991, Modulation of transforming growth factor-beta production in normal human osteoblast-like cells by 17 beta-estradiol and parathyroid hormone, Endocrinology, 129, 3313, 10.1210/endo-129-6-3313 · DOI
  32. Shevde, 2000, Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression, Proc Natl Acad Sci U S A, 97, 7829, 10.1073/pnas.130200197 · DOI · Paper page
  33. Srivastava, 2001, Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-κB ligand (RANKL)-induced JNK activation, J Biol Chem, 276, 8836, 10.1074/jbc.M010764200 · DOI
  34. Oursler, 1994, Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells, Proc Natl Acad Sci U S A, 91, 5227, 10.1073/pnas.91.12.5227 · DOI
  35. Frost, 1999, On the estrogen-bone relationship and postmenopausal bone loss: a new model, J Bone Miner Res, 14, 1473, 10.1359/jbmr.1999.14.9.1473 · DOI · Paper page
  36. Ledger, 1995, Role of parathyroid hormone in mediating nocturnal and age-related increases in bone resorption, J Clin Endocrinol Metab, 80, 3304
  37. Holick, 2007, Vitamin D deficiency, N Engl J Med, 357, 266, 10.1056/NEJMra070553 · DOI · Paper page
  38. Nordin, 1991, Evidence for a renal calcium leak in postmenopausal women, J Clin Endocrinol Metab, 72, 401, 10.1210/jcem-72-2-401 · DOI
  39. McKane, 1995, Mechanism of renal calcium conservation with estrogen replacement therapy in women in early postmenopause—a clinical research center study, J Clin Endocrinol Metab, 80, 3458
  40. Marie, 1993, In vitro production of cytokines by bone surface-derived osteoblastic cells in normal and osteoporotic postmenopausal women: relationship with cell proliferation, J Clin Endocrinol Metab, 77, 824
  41. Giustina, 1998, Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human, Endocr Rev, 19, 717
  42. Bennett, 1984, Insulin-like growth factors I and II, aging and bone density in women, J Clin Endocrinol Metab, 59, 701, 10.1210/jcem-59-4-701 · DOI
  43. Boonen, 1999, Down-regulation of the serum stimulatory components of the insulin-like growth factor (IGF) system (IGF-I, IGF-II, IGF binding protein [BP]-3, and IGFBP-5) in age-related (type II) femoral neck osteoporosis, J Bone Miner Res, 14, 2150, 10.1359/jbmr.1999.14.12.2150 · DOI
  44. Pfeilschifter, 2000, Concentrations of insulin-like growth factor (IGF)-I, -II, and IGF binding protein-4 and -5 in human bone cell conditioned medium did not change with age, Mech Ageing Dev, 117, 109, 10.1016/S0047-6374(00)00132-9 · DOI
  45. Heaney, 1978, Menopausal changes in calcium balance performance, J Lab Clin Med, 92, 953
  46. Ernst, 1989, Estradiol effects on proliferation, messenger ribonucleic acid for collagen and insulin-like growth factor-I, and parathyroid hormone-stimulated adenylate cyclase activity in osteoblastic cells from calvariae and long bones, Endocrinology, 125, 825, 10.1210/endo-125-2-825 · DOI
  47. Manolagas, 2000, Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis, Endocr Rev, 21, 115
  48. Gohel, 1999, Estrogen prevents glucocorticoid-induced apoptosis in osteoblasts in vivo and in vitro, Endocrinology, 140, 5339, 10.1210/endo.140.11.7135 · DOI
  49. Khastgir, 2001, Anabolic effect of estrogen replacement on bone in postmenopausal women with osteoporosis: histomorphometric evidence in a longitudinal study, J Clin Endocrinol Metab, 86, 289
  50. Tobias, 1999, Does estrogen stimulate osteoblast function in postmenopausal women?, Bone, 24, 121, 10.1016/S8756-3282(98)00156-2 · DOI
  51. Khosla, 2008, Osteoporosis in men, Endocr Rev, 29, 441, 10.1210/er.2008-0002 · DOI
  52. Khosla, 2010, Update in male osteoporosis, J Clin Endocrinol Metab, 95, 3, 10.1210/jc.2009-1740 · DOI
  53. Khosla, 1998, Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen, J Clin Endocrinol Metab, 83, 2266
  54. Khosla, 2006, Editorial: sex hormone binding globulin: inhibitor or facilitator (or both) of sex steroid action?, J Clin Endocrinol Metab, 91, 4764, 10.1210/jc.2006-1990 · DOI
  55. Clarke, 2009, Androgens and bone, Steroids, 74, 296, 10.1016/j.steroids.2008.10.003 · DOI
  56. Greendale, 1997, Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo study, J Bone Miner Res, 12, 1833, 10.1359/jbmr.1997.12.11.1833 · DOI
  57. Khosla, 2008, Comparison of sex steroid measurements in men by immunoassay versus mass spectroscopy and relationships with cortical and trabecular volumetric bone mineral density, Osteoporos Int, 19, 1465, 10.1007/s00198-008-0591-5 · DOI
  58. Mellström, 2008, Older men with low serum estradiol and high serum SHBG have an increased risk of fractures, J Bone Miner Res, 23, 1552, 10.1359/jbmr.080518 · DOI · Paper page
  59. Center, 1999, Hormonal and biochemical parameters in the determination of osteoporosis in elderly men, J Clin Endocrinol Metab, 84, 3626
  60. Ongphiphadhanakul, 1998, Serum oestradiol and oestrogen-receptor gene polymorphism are associated with bone mineral density independently of serum testosterone in normal males, Clin Endocrinol (Oxf), 49, 803, 10.1046/j.1365-2265.1998.00631.x · DOI
  61. ven den Beld, 2000, Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men, J Clin Endocrinol Metab, 85, 3276
  62. Amin, 2000, Association of hypogonadism and estradiol levels with bone mineral density in elderly men in the Framingham study, Ann Intern Med, 133, 951, 10.7326/0003-4819-133-12-200012190-00010 · DOI
  63. Khosla, 2001, Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men, J Clin Endocrinol Metab, 86, 3556, 10.1210/jcem.86.8.7736 · DOI · Paper page
  64. Gennari, 2003, Longitudinal association between sex hormone levels, bone loss, and bone turnover in elderly men, J Clin Endocrinol Metab, 88, 5327, 10.1210/jc.2003-030736 · DOI · Paper page
  65. Taxel, 2001, The effect of aromatase inhibition on sex steroids, gonadotropins, and markers of bone turnover in older men, J Clin Endocrinol Metab, 86, 2869
  66. Sanyal, 2008, Regulation of bone turnover by sex steroids in men, J Bone Miner Res, 23, 705, 10.1359/jbmr.071212 · DOI
  67. Gennari, 2008, Estrogen and fracture risk in men, J Bone Miner Res, 23, 1548, 10.1359/jbmr.0810c · DOI
  68. Turner, 1990, Differential effects of androgens on cortical bone histomorphometry in gonadectomized male and female rats, J Orthop Res, 8, 612, 10.1002/jor.1100080418 · DOI · Paper page
  69. Kennel, 2003, Role of parathyroid hormone in mediating age-related changes in bone resorption in men, Osteoporos Int, 14, 631, 10.1007/s00198-003-1417-0 · DOI
  70. Amin, 2007, High serum IGFBP-2 is predictive of increased bone turnover in aging men and women, J Bone Miner Res, 22, 799, 10.1359/jbmr.070306 · DOI
  71. Shi, 2008, Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo, Proc Natl Acad Sci U S A, 105, 20529, 10.1073/pnas.0808701106 · DOI
  72. Mödder, 2010, Relation of serum serotonin levels to bone density and structural parameters in women, J Bone Miner Res, 25, 415, 10.1359/jbmr.090721 · DOI
  73. Seeman, 1997, From density to structure: growing up and growing old on the surfaces of bone, J Bone Miner Res, 12, 509, 10.1359/jbmr.1997.12.4.509 · DOI
  74. Melton, 2006, Does reduced skeletal loading account for age-related bone loss?, J Bone Miner Res, 21, 1847, 10.1359/jbmr.060908 · DOI
  75. Riggs, 1986, Medical progress series: involutional osteoporosis, N Engl J Med, 314, 1676, 10.1056/NEJM198606263142605 · DOI
  76. Frost, 1997, On age-related bone loss: insights from a new paradigm, J Bone Miner Res, 12, 1539, 10.1359/jbmr.1997.12.10.1539 · DOI
  77. Frost, 2000, Why the ISMNI and the Utah paradigm? Their role in skeletal and extraskeletal disorders, J Musculoskelet Neuronal Interact, 1, 5

Cited by

Sorted by citations

Metadata

Authors
Clarke, B. L., & Khosla, S.
Venue
Radiologic Clinics of North America
Publisher
Elsevier BV
Published
2010-05
Volume
48
Issue
3
Pages
483-495
ISSN
0033-8389
Cited by
221
References
14
Language
en
Funders
National Institutes of Health

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review