New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate

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Metabolism of Inflammation Limited by AMPK and Pseudo-Starvation

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Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines.

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Green Tea Consumption and Mortality Due to Cardiovascular Disease, Cancer, and All Causes in Japan

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Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability.

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Reciprocal Regulation of Endothelial Nitric-oxide Synthase by Ca2+-Calmodulin and Caveolin

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Analysis of plasma and urinary tea polyphenols in human subjects.

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Epigallocatechin Gallate, a Constituent of Green Tea, Represses Hepatic Glucose Production

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Dietary Polyphenols May Affect DNA Methylation

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Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation

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Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein

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Stability, cellular uptake, biotransformation, and efflux of tea polyphenol (-)-epigallocatechin-3-gallate in HT-29 human colon adenocarcinoma cells.

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Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress

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Green Tea Polyphenols Block Endotoxin-Induced Tumor Necrosis Factor-Production and Lethality in a Murine Model

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EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR

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Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins.

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Tumor Necrosis Factor-α Induces Endothelial Dysfunction in the Prediabetic Metabolic Syndrome

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Green Tea Supplementation Affects Body Weight, Lipids, and Lipid Peroxidation in Obese Subjects with Metabolic Syndrome

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A Constituent of Green Tea, Epigallocatechin-3-gallate, Activates Endothelial Nitric Oxide Synthase by a Phosphatidylinositol-3-OH-kinase-, cAMP-dependent Protein Kinase-, and Akt-dependent Pathway and Leads to Endothelial-dependent Vasorelaxation

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Epigallocatechin-3-gallate (EGCG), A Green Tea Polyphenol, Suppresses Hepatic Gluconeogenesis through 5′-AMP-activated Protein Kinase

Collins, Q. F., Liu, H.-Y., Pi, J., Liu, Z., Quon, M. J., & Cao, W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702390200 · Cited by 333 · see citing works

Curcumin: A Potential Neuroprotective Agent in Parkinson's Disease

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Green Tea Epigallocatechin-3-Gallate Mediates T Cellular NF-κB Inhibition and Exerts Neuroprotection in Autoimmune Encephalomyelitis

Aktaş, O., Prozorovski, T., Тихоновна, С. А., Savaskan, N. E., Lauster, R., Kloetzel, P., Infante‐Duarte, C., Brocke, S., & Zipp, F. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.9.5794 · Cited by 316 · see citing works

Green tea extract and (−)‐epigallocatechin‐3‐gallate, the major tea catechin, exert oxidant but lack antioxidant activities

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Insulin resistance and the metabolic syndrome

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Mechanism of Action of (−)-Epigallocatechin-3-Gallate: Auto-oxidation–Dependent Inactivation of Epidermal Growth Factor Receptor and Direct Effects on Growth Inhibition in Human Esophageal Cancer KYSE 150 Cells

Hou, Z., Sang, S., You, H., Lee, M., Hong, J., Chin, K., & Yang, C. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0480 · Cited by 298 · see citing works

Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway

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Effect of black and green tea polyphenols on c-jun phosphorylation and H2O2 production in transformed and non-transformed human bronchial cell lines: possible mechanisms of cell growth inhibition and apoptosis induction

Yang, G. (2000) · Carcinogenesis · doi:10.1093/carcin/21.11.2035 · Cited by 268 · see citing works

Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate

Nakagawa, H. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh168 · Cited by 249 · see citing works

Upregulation of heme oxygenase-1 by Epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/Akt and ERK pathways

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Pro-oxidative activities and dose–response relationship of (−)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro

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Epigallocatechin Gallate, a Green Tea Polyphenol, Mediates NO-dependent Vasodilation Using Signaling Pathways in Vascular Endothelium Requiring Reactive Oxygen Species and Fyn

Kim, J., Formoso, G., Li, Y., Potenza, M. A., Marasciulo, F. L., Montagnani, M., & Quon, M. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609725200 · Cited by 236 · see citing works

Epigallocatechin-3-gallate Inhibits Epidermal Growth Factor Receptor Signaling Pathway

Sah, J. F., Balasubramanian, S., Eckert, R. L., & Rorke, E. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312333200 · Cited by 234 · see citing works

Differential Effects of Green Tea–Derived Catechin on Developing Versus Established Atherosclerosis in Apolipoprotein E–Null Mice

Chyu, K., Babbidge, S. M., Zhao, X., Dandillaya, R., Rietveld, A. G., Yano, J., Dimayuga, P. C., Cercek, B., & Shah, P. K. (2004) · Circulation · doi:10.1161/01.cir.0000128034.70732.c2 · Cited by 223 · see citing works

Inhibitory Effect of (−)‐Epigallocatechin‐3‐Gallate on Lipid Accumulation of 3T3‐L1 Cells

Moon, H., Chung, C.-S., Lee, H., Kim, T., Choi, Y., & Cho, C. (2007) · Obesity · doi:10.1038/oby.2007.309 · Cited by 220 · see citing works

Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet

Chen, N., Bezzina, R., Hinch, E., et al. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.10.003 · Cited by 218 · see citing works

Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells

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Green Tea (–)-Epigallocatechin-3-Gallate Reduces Body Weight with Regulation of Multiple Genes Expression in Adipose Tissue of Diet-Induced Obese Mice

Lee, M.-S., Kim, C., & Kim, Y. (2009) · Annals of Nutrition and Metabolism · doi:10.1159/000214834 · Cited by 215 · see citing works

Polyphenols and Health: Current State and Progress

Tomás-Barberán, F. A., & Andrés‐Lacueva, C. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300671j · Cited by 205 · see citing works

Epigallocatechin Gallate (EGCG) Stimulates Autophagy in Vascular Endothelial Cells

Kim, H.-S., Montana, V., Jang, H.-J., Parpura, V., & Kim, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.477505 · Cited by 192 · see citing works

Epigallocatechin, a Green Tea Polyphenol, Attenuates Myocardial Ischemia Reperfusion Injury in Rats

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Cellular and molecular effects of resveratrol in health and disease

Yu, W., Fu, Y., & Wang, W. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23431 · Cited by 182 · see citing works

Phase I Trial of Daily Oral Polyphenon E in Patients With Asymptomatic Rai Stage 0 to II Chronic Lymphocytic Leukemia

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Epigallocatechin‐3‐gallate inhibits STAT‐1 activation and protects cardiac myocytes from ischemia/reperfusion‐ induced apoptosis

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Green Tea Epigallocatechin 3-Gallate Accumulates in Mitochondria and Displays a Selective Antiapoptotic Effect Against Inducers of Mitochondrial Oxidative Stress in Neurons

Schroeder, E. K., Kelsey, N. A., Doyle, J., Breed, E. R., Bouchard, R. J., Loucks, F. A., Harbison, R. A., & Linseman, D. A. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2215 · Cited by 177 · see citing works

Tea Catechins with a Galloyl Moiety Suppress Postprandial Hypertriacylglycerolemia by Delaying Lymphatic Transport of Dietary Fat in Rats

Ikeda, I., Tsuda, K., Suzuki, Y., et al. (2005) · Journal of Nutrition · doi:10.1093/jn/135.2.155 · Cited by 175 · see citing works

TLR4 Signaling Inhibitory Pathway Induced by Green Tea Polyphenol Epigallocatechin-3-Gallate through 67-kDa Laminin Receptor

Byun, E. H., Fujimura, Y., Yamada, K., & Tachibana, H. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903742 · Cited by 174 · see citing works

Flavonoid Basics: Chemistry, Sources, Mechanisms of Action, and Safety

Corcoran, M. P., McKay, D. L., & Blumberg, J. B. (2012) · Journal of Nutrition in Gerontology and Geriatrics · doi:10.1080/21551197.2012.698219 · Cited by 173 · see citing works

Epigallocathechin-3 Gallate Selectively Inhibits the PDGF-BB–induced Intracellular Signaling Transduction Pathway in Vascular Smooth Muscle Cells and Inhibits Transformation ofsis-transfected NIH 3T3 Fibroblasts and Human Glioblastoma Cells (A172)

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EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages

Li, W., Zhu, S., Li, J., Assa, A., Jundoria, A., Xu, J., Fan, S., Eissa, N. T., Tracey, K. J., Sama, A. E., et al. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.02.015 · Cited by 172 · see citing works

SIRT1 stimulation by polyphenols is affected by their stability and metabolism

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67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis

Kumazoe, M., Sugihara, K., Tsukamoto, S., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64768 · Cited by 165 · see citing works

Tea catechins inhibit angiogenesis in vitro, measured by human endothelial cell growth, migration and tube formation, through inhibition of VEGF receptor binding

Kondo, T., Ohta, T., Igura, K., Hara, Y., & Kaji, K. (2002) · Cancer Letters · doi:10.1016/s0304-3835(02)00007-1 · Cited by 163 · see citing works

Autophagy, polyphenols and healthy ageing

Pallauf, K., & Rimbach, G. H. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.03.008 · Cited by 162 · see citing works

Fenton Reaction Is Primarily Involved in a Mechanism of (−)-Epigallocatechin-3-gallate to Induce Osteoclastic Cell Death

Nakagawa, H., Wachi, M., Woo, J., Kato, M., Kasai, S., Takahashi, F., Lee, I.-S., & Nagai, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6622 · Cited by 161 · see citing works

Plasma concentrations of individual tea catechins after a single oral dose in humans

van Amelsvoort, J. M. M., Hof, K. H. V. H., Mathot, J. N. J. J., MULDER, T. P. J., Wiersma, A., & Tijburg, L. B. M. (2001) · Xenobiotica · doi:10.1080/00498250110079149 · Cited by 155 · see citing works

Catechin-induced activation of the LKB1/AMP-activated protein kinase pathway

Murase, T., Misawa, K., Haramizu, S., & Hase, T. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.03.021 · Cited by 154 · see citing works

Phytochemical properties and antioxidant capacities of various colored berries

Chen, L., Xin, X., Yuan, Q., Su, D., & Liu, W. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6216 · Cited by 150 · see citing works

DOSE-DEPENDENT LEVELS OF EPIGALLOCATECHIN-3-GALLATE IN HUMAN COLON CANCER CELLS AND MOUSE PLASMA AND TISSUES

Lambert, J. D., Lee, M., Diamond, L., et al. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.003434 · Cited by 146 · see citing works

The Intermediate Filament Protein Vimentin Is a New Target for Epigallocatechin Gallate

Ermakova, S. P., Choi, B. Y., Choi, H. S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414185200 · Cited by 145 · see citing works

Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome

Valenti, D., Rasmo, D. D., Signorile, A., Rossi, L., Lidia de, B. A. R. I., Scala, I., Granese, B., Papa, S., & Vacca, R. A. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.12.011 · Cited by 144 · see citing works

Green tea catechins ameliorate adipose insulin resistance by improving oxidative stress

Yan, J., Zhao, Y., Suo, S., Liu, Y., & Zhao, B. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.01.033 · Cited by 143 · see citing works

Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells

Ren, F., Zhang, S., Mitchell, S. H., Butler, R., & Young, C. Y. (2000) · Oncogene · doi:10.1038/sj.onc.1203511 · Cited by 141 · see citing works

Does supplementation with green tea extract improve insulin resistance in obese type 2 diabetics? A randomized, double-blind, and placebo-controlled clinical trial.

Hsu, C.-H., Liao, Y.-L., Lin, S.-C., Tsai, T., Huang, C.-J., & Chou, P. (2011) · PubMed · Cited by 140 · see citing works

Unanticipated Benefits of CAM Therapies for Back Pain: An Exploration of Patient Experiences

Hsu, C. W., BlueSpruce, J., Sherman, K. J., & Cherkin, D. C. (2010) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2009.0188 · Cited by 128 · see citing works

EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells

Shimizu, M., Deguchi, A., Hara, Y., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.06.182 · Cited by 128 · see citing works

Green tea catechin, epigallocatechin‐3‐gallate, inhibits vascular endothelial growth factor angiogenic signaling by disrupting the formation of a receptor complex

Rodriguez, S. K., Guo, W., Liu, L., Band, M., Paulson, E. K., & Meydani, M. (2005) · International Journal of Cancer · doi:10.1002/ijc.21545 · Cited by 127 · see citing works

Inhibition of Fatty Acid Synthase by Polyphenols

Tian, W. (2006) · Current Medicinal Chemistry · doi:10.2174/092986706776361012 · Cited by 116 · see citing works

Role of STAT‐1 and STAT‐3 in ischaemia/reperfusion injury

Stephanou, A. (2004) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2004.tb00476.x · Cited by 110 · see citing works

Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells

Chen, D., Pamu, S., Cui, Q. C., Chan, T. H., & Dou, Q. P. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.03.002 · Cited by 106 · see citing works

Epigallocatechin gallate induces expression of heme oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2 that suppresses proinflammatory actions of TNF-α

Pullikotil, P., Chen, H., Muniyappa, R., Greenberg, C. C., Yang, S., Reiter, C. E. N., Lee, J.-W., Chung, J. H., & Quon, M. J. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.06.007 · Cited by 106 · see citing works

Pleiotropic preventive effects of dietary polyphenols in cardiovascular diseases

Kishimoto, Y., Tani, M., & Kondo, K. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.29 · Cited by 104 · see citing works

Epigallocatechin-3-O-gallate (EGCG) attenuates FFAs-induced peripheral insulin resistance through AMPK pathway and insulin signaling pathway in vivo

Li, Y., Zhao, S., Zhang, W., Zhao, P., He, B., Wu, N., & Han, P. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.03.036 · Cited by 103 · see citing works

(−)-Epigallocatechin-3-Gallate Induces Non-Apoptotic Cell Death in Human Cancer Cells via ROS-Mediated Lysosomal Membrane Permeabilization

Zhang, Y., Yang, N., Zhou, F., Shen, T., Duan, T., Zhou, J., Shi, Y., Zhu, X.-Q., & Shen, H.-M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046749 · Cited by 103 · see citing works

Study of the mechanisms involved in the vasorelaxation induced by (−)‐epigallocatechin‐3‐gallate in rat aorta

Álvarez, E., Campos‐Toimil, M., Justiniano‐Basaran, H., et al. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706507 · Cited by 102 · see citing works

Green Tea Polyphenol Epigallocatechin Gallate Reduces Endothelin-1 Expression and Secretion in Vascular Endothelial Cells: Roles for AMP-Activated Protein Kinase, Akt, and FOXO1

Reiter, C. E. N., Kim, J., & Quon, M. J. (2009) · Endocrinology · doi:10.1210/en.2009-0997 · Cited by 101 · see citing works

Roles of Catalase and Hydrogen Peroxide in Green Tea Polyphenol-Induced Chemopreventive Effects

Yamamoto, T., Lewis, J. B., Wataha, J. C., et al. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.058891 · Cited by 101 · see citing works

Effects of the green tea polyphenol epigallocatechin-3-gallate on high-fat diet-induced insulin resistance and endothelial dysfunction

Jang, H.-J., Ridgeway, S. D., & Kim, J. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00434.2013 · Cited by 93 · see citing works

Green Tea Polyphenol EGCG Sensing Motif on the 67-kDa Laminin Receptor

Fujimura, Y., Sumida, M., Sugihara, K., Tsukamoto, S., Yamada, K., & Tachibana, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037942 · Cited by 90 · see citing works

Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 mice

Giunta, B. N., Hou, H., Zhu, Y., Salemi, J., Ruscin, A., Shytle, R. D., & Tan, J. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.01.026 · Cited by 87 · see citing works

(−)Epigallocatechin-gallate (EGCG) prevents mitochondrial damage in isoproterenol-induced cardiac toxicity in albino Wistar rats: A transmission electron microscopic and in vitro study

Devika, P. T., & Prince, P. S. M. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.03.008 · Cited by 82 · see citing works

The Antioxidant (–)-Epigallocatechin-3-gallate Inhibits Rat Hepatic Stellate Cell Proliferation in Vitro by Blocking the Tyrosine Phosphorylation and Reducing the Gene Expression of Platelet-derived Growth Factor-β Receptor

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The anti-adipogenic effects of (-)epigallocatechin gallate are dependent on the WNT/β-catenin pathway

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