The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Breathing new life into nitric oxide signaling: A brief overview of the interplay between oxygen and nitric oxide
Open accessAbstract
Nitric oxide ((•)NO, nitrogen monoxide) is one of the most unique biological signaling molecules associated with a multitude of physiologic and pathological conditions. In order to fully appreciate its numerous roles, it is essential to understand its basic biochemical properties. Most signaling effector molecules such as steroids or proteins have a significant life-span and function through classical receptor-ligand interactions. (•)NO, however, is a short-lived free-radical gas that only reacts with two types of molecules under biological conditions; metals and other free radicals. These simple interactions can lead to a myriad of complex intermediates which in turn have their own phenotypic effects. For these reasons, responses to (•)NO often appear to be random or contradictory when outcomes are compared across various experimental settings. This article will serve as a brief overview of the chemical, biological, and microenvironmental factors that dictate (•)NO signaling with an emphasis on (•)NO metabolism. The prominent role that oxygen (dioxygen, O2) plays in (•)NO metabolism and how it influences the biological effects of (•)NO will be highlighted. This information and these concepts are intended to help students and investigators think about the interpretation of data from experiments where biological effects of (•)NO are being elucidated.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · cited 1×
“Although nitrate and nitrite were once thought to be carcinogenic, it is now becoming increasingly clear that the physiologic benefits derived from their ability to generate NO far outweigh their deleterious properties [39].”
BackgroundThe chemical biology of nitric oxide: Implications in cellular signaling
Thomas, D. D., Ridnour, L. A., Isenberg, J. S., Flores-Santana, W., Switzer, C. H., Donzelli, S., Hussain, P., Vecoli, C., Paolocci, N., Ambs, S., et al. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.020 · Cited by 975
Self-citationClementi, E., Brown, G. C., Feelisch, M., & Moncada, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7631 · Cited by 863
Liu, X., Miller, M. J. S., Joshi, M. S., Thomas, D. D., & Lancaster, J. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2175 · Cited by 602
Self-citationStructure and Regulation of Soluble Guanylate Cyclase
Derbyshire, E. R., & Marletta, M. A. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-050410-100030 · Cited by 466
S-nitrosation of serum albumin by dinitrosyl-iron complex
Boese, M., Mordvintcev, P. I., Vanin, A. F., Busse, R., & Mülsch, A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29244 · Cited by 259
Bosworth, C. A., Toledo, J. C., Zmijewski, J. W., Li, Q., & Lancaster, J. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710416106 · Cited by 220
Dinitrosyl iron complexes with thiolate ligands: physico-chemistry, biochemistry and physiology
Vanin, A. F. (2009) · Nitric Oxide · doi:10.1016/j.niox.2009.03.005 · Cited by 217
Nitrite: A physiological store of nitric oxide and modulator of mitochondrial function
Shiva, S. (2013) · Redox Biology · doi:10.1016/j.redox.2012.11.005 · Cited by 207 · cited 1×
“There are other radical – radical reactions with NO that have biological consequences (for detailed reviews on oxidative stress see and NO reactivity see [3,6,9,29,30]).”
Background
Cited by
13 reasons why the brain is susceptible to oxidative stress
Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215
Progress and Promise of Nitric Oxide‐Releasing Platforms
Yang, T., Zelikin, A. N., & Chandrawati, R. (2018) · Advanced Science · doi:10.1002/advs.201701043 · Cited by 309
On the history of oxidative stress: Concept and some aspects of current development
Sies, H. (2018) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2018.01.002 · Cited by 285
Chen, J., Chen, L., Fang, Y., Zeng, F., & Wu, S. (2022) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2021.100570 · Cited by 29
Metadata
- Authors
- Thomas, D. D.
- Venue
- Redox Biology
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 5
- Pages
- 225-233
- ISSN
- 2213-2317 (ISSN-L)
- OpenAlex
- W392890894
- Cited by
- 168
- References
- 18
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Breathing new life into nitric oxide signaling: A brief overview of the interplay between oxygen and nitric oxide. https://app.cochat.ai/papers/10.1016/j.redox.2015.05.002
- The paper
- Thomas, D. D. (2015). Breathing new life into nitric oxide signaling: A brief overview of the interplay between oxygen and nitric oxide. Redox Biology. https://doi.org/10.1016/j.redox.2015.05.002
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
