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Calcium and ROS: A mutual interplay
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Calcium is an important second messenger involved in intra- and extracellular signaling cascades and plays an essential role in cell life and death decisions. The Ca(2+) signaling network works in many different ways to regulate cellular processes that function over a wide dynamic range due to the action of buffers, pumps and exchangers on the plasma membrane as well as in internal stores. Calcium signaling pathways interact with other cellular signaling systems such as reactive oxygen species (ROS). Although initially considered to be potentially detrimental byproducts of aerobic metabolism, it is now clear that ROS generated in sub-toxic levels by different intracellular systems act as signaling molecules involved in various cellular processes including growth and cell death. Increasing evidence suggests a mutual interplay between calcium and ROS signaling systems which seems to have important implications for fine tuning cellular signaling networks. However, dysfunction in either of the systems might affect the other system thus potentiating harmful effects which might contribute to the pathogenesis of various disorders.
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“However, sustained elevation in the cellular calcium signal stimulates higher mitochondrial reactive oxygen species (ROS) generation (28) due to enhanced electron flow through respiratory chain and subsequent inhibition of complexes I and III of ubiquinone (Q) cycle.”
From Mechanistic inferences on metabolic dysfunction in posttraumatic stress disorder from an integrated model and multiomic analysis: role of glucocorticoid receptor sensitivity (2019) · cites this paper as [28]
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Metadata
- Authors
- Görlach, A., Bertram, K., Hudecova, S., & Krizanova, O.
- Affiliations
- German Centre for Cardiovascular Research (DE)
- Deutsches Herzzentrum München (DE)
- Corresponding author
- Görlach, Agnes
- ORCID
- Görlach, Agnes
- Venue
- Redox Biology
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 6
- Pages
- 260-271
- ISSN
- 2213-2317 (ISSN-L)
- PMC
- PMC4556774
- OpenAlex
- W1165140024
- Cited by
- 1,546
- References
- 180
- Citations by year
- 2026: 128 · 2025: 188 · 2024: 195 · 2023: 184 · 2022: 177 · 2021: 179 · 2020: 141 · 2019: 133 · 2018: 115 · 2017: 72 · 2016: 30 · 2015: 3
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Redox Biology (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Funders
- Bundesministerium für Bildung und Forschung (SAV 2/0074)
- Deutsches Zentrum für Herz-Kreislaufforschung
- Deutsche Forschungsgemeinschaft (DFG-GO709/4-5)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- calcium signaling, reactive oxygen species, second messengers, cell death, cell signaling networks, redox signaling, intracellular calcium stores
- MeSH terms
- Animals, Calcium, Cell Membrane, Endoplasmic Reticulum, Eukaryotic Cells, Gene Expression Regulation, Humans, Mitochondria, Calcium Channels, Cell Death, Reactive Oxygen Species, Oxidative Stress, NADPH Oxidases, Calcium Signaling, Plasma Membrane Calcium-Transporting ATPases
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