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Ginsenoside Rb1 inhibits astrocyte activation and promotes transfer of astrocytic mitochondria to neurons against ischemic stroke

Ni, Xue-Chun, Wang, Hong-Fei, Cai, Yuan-Yuan, Yang, Dai, Alolga, Raphael N., Liu, Baolin, Li, Jia, Huang, Feng-Qing·2022·Redox Biology
DOI 10.1016/j.redox.2022.102363PMC PMC9198466
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  1. [3]Chaturvedi R.K. Beal M.F. Mitochondrial diseases of the brain Free Radic. Biol. Med. 63 2013 1 29 10.1016/j.freeradbiomed.2013.03.018 23567191 · DOI
  2. [4]Yin F. Boveris A. Cadenas E. Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration Antioxidants Redox Signal. 20 2014 353 371 10.1089/ars.2012.4774 PMC3887431 22793257 · DOI
  3. [5]Patel R.A.G. McMullen P.W. Neuroprotection in the treatment of acute ischemic stroke Prog. Cardiovasc. Dis. 59 2017 542 548 10.1016/j.pcad.2017.04.005 28465001 · DOI
  4. [7]Sonnewald U. Qu H. Aschner M. Pharmacology and toxicology of astrocyte- neuron glutamate transport and cycling J. Pharmacol. Exp. Therapeut. 301 2002 1 6 10.1124/jpet.301.1.1 11907150 · DOI
  5. [8]Song X. Gong Z. Liu K. Baicalin combats glutamate excitotoxicity via protecting glutamine synthetase from ROS-induced 20S proteasomal degradation Redox Biol. 34 2020 101559 10.1016/j.redox.2020.101559 PMC7260594 32473460 · DOI
  6. [9]Verkhratsky A. Nedergaard M. Hertz L. Why are astrocytes important? Neurochem. Res. 40 2015 389 401 10.1007/s11064-014-1403-2 25113122 · DOI
  7. [10]Pekny M. Pekna M. Astrocyte reactivity and reactive astrogliosis: costs and benefits Physiol. Rev. 94 2014 1077 1098 10.1152/physrev.00041.2013 25287860 · DOI · Paper page
  8. [11]Choudhury G.R. Ding S. Reactive astrocytes and therapeutic potential in focal ischemic stroke Neurobiol. Dis. 85 2016 234 244 10.1016/j.nbd.2015.05.003 25982835 PMC4644522 · DOI
  9. [12]Hol E.M. Pekny M. Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system Curr. Opin. Cell Biol. 32 2015 121 130 10.1016/j.ceb.2015.02.004 25726916 · DOI · Paper page
  10. [15]Swanson R.A. Ying W. Kauppinen T.M. Astrocyte influences on ischemic neuronal death Curr. Mol. Med. 4 2004 193 205 10.2174/1566524043479185 15032713 · DOI
  11. [17]Hayakawa K. Esposito E. Wang X. Transfer of mitochondria from astrocytes to neurons after stroke Nature 535 2016 551 555 10.1038/nature18928 27466127 PMC4968589 · DOI · Paper page
  12. [18]Shi Y.H. Li Y. Wang Y. Ginsenoside-Rb1 for ischemic stroke: a systematic review and meta-analysis of preclinical evidence and possible mechanisms Front. Pharmacol. 11 2020 285 10.3389/fphar.2020.00285 32296332 PMC7137731 · DOI
  13. [19]Jiang L. Yin X. Chen Y.H. Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I Theranostics 11 2021 1703 1720 10.7150/thno.43895 33408776 PMC7778584 · DOI
  14. [20]Yang J. Su Y. Richmond A. Antioxidants tiron and N-acetyl-L-cysteine differentially mediate apoptosis in melanoma cells via a reactive oxygen species-independent NF-kappaB pathway Free Radic. Biol. Med. 42 2007 1369 1380 10.1016/j.freeradbiomed.2007.01.036 17395010 PMC1905840 · DOI
  15. [21]Gao K. Wang C.R. Jiang F. Traumatic scratch injury in astrocytes triggers calcium influx to activate the JNK/c-Jun/AP-1 pathway and switch on GFAP expression Glia 61 2013 2063 2077 10.1002/glia.22577 24123203 · DOI
  16. [23]Testa C.M. Sherer T.B. Greenamyre J.T. Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures Brain Res. Mol. Brain Res. 134 2005 109 118 10.1016/j.molbrainres.2004.11.007 15790535 · DOI
  17. [24]Seo B.B. Kitajima-Ihara T. Chan E.K. Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells Proc. Natl. Acad. Sci. U.S.A. 95 1998 9167 9171 10.1073/pnas.95.16.9167 9689052 PMC21310 · DOI
  18. [25]Voloboueva L.A. Suh S.W. Swanson R.A. Inhibition of mitochondrial function in astrocytes: implications for neuroprotection J. Neurochem. 102 2007 1383 1394 10.1111/j.1471-4159.2007.04634.x 17488276 PMC3175820 · DOI
  19. [27]Pugliese A.M. Traini C. Cipriani S. The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices Br. J. Pharmacol. 157 2009 818 830 10.1111/j.1476-5381.2009.00218.x 19422385 PMC2721266 · DOI
  20. [28]Ishii T. Takanashi Y. Sugita K. Endogenous reactive oxygen species cause astrocyte defects and neuronal dysfunctions in the hippocampus: a new model for aging brain Aging Cell 16 2017 39 51 10.1111/acel.12523 27623715 PMC5242301 · DOI
  21. [29]Hirst J. King M.S. Pryde K.R. The production of reactive oxygen species by complex I Biochem. Soc. Trans. 36 2008 976 980 10.1042/BST0360976 18793173 · DOI · Paper page
  22. [31]Marella M. Seo B.B. Nakamaru-Ogiso E. Protection by the NDI1 gene against neurodegeneration in a rotenone rat model of Parkinson's disease PLoS One 3 2008 e1433 10.1371/journal.pone.0001433 18197244 PMC2175531 · DOI · Paper page
  23. [32]Lesnefsky E.J. Chen Q. Moghaddas S. Blockade of electron transport during ischemia protects cardiac mitochondria J. Biol. Chem. 279 2004 47961 47967 10.1074/jbc.M409720200 15347666 · DOI
  24. [34]Gollihue J.L. Norris C.M. Astrocyte Mitochondria: central players and potential therapeutic targets for neurodegenerative diseases and injury Ageing Res. Rev. 59 2020 101039 10.1016/j.arr.2020.101039 PMC7422487 32105849 · DOI · Paper page
  25. [35]Jackson J.G. Robinson M.B. Regulation of mitochondrial dynamics in astrocytes: mechanisms, consequences, and unknowns Glia 66 2018 1213 1234 10.1002/glia.23252 29098734 PMC5904024 · DOI
  26. [36]Voloboueva L.A. Suh S.W. Swanson R.A. Inhibition of mitochondrial function in astrocytes: implications for neuroprotection J. Neurochem. 102 2007 1383 1394 10.1111/j.1471-4159.2007.04634.x 17488276 PMC3175820 · DOI
  27. [37]Y. Qin, X. Jiang, Q. Yang, et al., The functions, methods, and mobility of and mitochondrial transfer between cells, Front. Oncol. 11 (2021) 672781. doi: 10.3389/ fonc.2021.672781. PMC8141658 34041035
  28. [38]Hayakawa K. Chan S.J. Mandeville E.T. Protective effects of endothelial progenitor cell-derived extracellular mitochondria in brain endothelium Stem Cell. 36 2018 1404 1410 10.1002/stem.2856 PMC6407639 29781122 · DOI
  29. [39]McCully J.D. Cowan D.B. Pacak C.A. Injection of isolated mitochondria during early reperfusion for cardioprotection Am. J. Physiol. Heart Circ. Physiol. 296 2009 H94 H105 10.1152/ajpheart.00567.2008 18978192 PMC2637784 · DOI
  30. [40]Choudhury G.R. Ding S. Reactive astrocytes and therapeutic potential in focal ischemic stroke Neurobiol. Dis. 85 2016 234 244 10.1016/j.nbd.2015.05.003 25982835 PMC4644522 · DOI
  31. [41]Cekanaviciute E. Buckwalter M.S. Astrocytes: integrative regulators of neuroinflammation in stroke and other neurological diseases Neurotherapeutics 13 2016 685 701 10.1007/s13311-016-0477-8 27677607 PMC5081110 · DOI · Paper page
  32. [42]Sun C. Lai X. Huang X. Protective effects of ginsenoside Rg1 on astrocytes and cerebral ischemic-reperfusion mice Biol. Pharm. Bull. 37 2014 1891 1898 10.1248/bpb.b14-00394 25451838 · DOI
  33. [43]Hou J. Kim S. Sung C. Ginsenoside Rg3 prevents oxidative stress-induced astrocytic senescence and ameliorates senescence paracrine effects on glioblastoma Molecules 22 2017 1516 10.3390/molecules22091516 PMC6151485 28891967 · DOI
  34. [44]Lou Y.X. Wang Z.Z. Xia C.Y. The protective effect of ginsenoside Rg1 on depression may benefit from the gap junction function in hippocampal astrocytes Eur. J. Pharmacol. 882 2020 173309 10.1016/j.ejphar.2020.173309 32598952 · DOI

Cited by

Sorted by citations

Authors
Ni, X.-C., Wang, H.-F., Cai, Y.-Y., Yang, D., Alolga, R. N., Liu, B., Li, J., & Huang, F.-Q.
ORCID
Huang, Feng-Qing
Venue
Redox Biology
Publisher
Elsevier BV
Published
2022-08
Volume
54
Pages
102363
ISSN
2213-2317
DOI
10.1016/j.redox.2022.102363
PMC
PMC9198466
Cited by
203
References
10
Language
en
Licence
Funders
  • Postdoctoral Research Foundation of China (2020M671660)
  • National Natural Science Foundation of China (82003978, 82003979)
  • China Postdoctoral Science Foundation

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