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Cited by 93Mitochondrial Function and PathologyNeuroinflammation and Neurodegeneration MechanismsAutophagy in Disease and Therapy

Astrocyte mitochondria: Central players and potential therapeutic targets for neurodegenerative diseases and injury

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Gollihue, J.L., Norris, C.M.·2020·Ageing Research Reviews
DOI 10.1016/j.arr.2020.101039PMC PMC7422487
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Abstract

Mitochondrial function has long been the focus of many therapeutic strategies for ameliorating age-related neurodegeneration and cognitive decline. Historically, the role of mitochondria in non-neuronal cell types has been overshadowed by neuronal mitochondria, which are responsible for the bulk of oxidative metabolism in the brain. Despite this neuronal bias, mitochondrial function in glial cells, particularly astrocytes, is increasingly recognized to play crucial roles in overall brain metabolism, synaptic transmission, and neuronal protection. Changes in astrocytic mitochondrial function appear to be intimately linked to astrocyte activation/reactivity found in most all age-related neurodegenerative diseases. Here, we address the importance of mitochondrial function to astrocyte signaling and consider how mitochondria could contribute to both the detrimental and protective properties of activated astrocytes. Strategies for protecting astrocytic mitochondrial function, promoting bidirectional transfer of mitochondria between astrocytes and neurons, and transplanting healthy mitochondria to diseased nervous tissue are also discussed.

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  • The specific role of substantia nigra pars compacta astrocytic mitochondria in contributing to neurodegeneration is a relatively unexplored but active area of investigation.

    “the specific role of SNc astrocytic mitochondria in contributing to neurodegeneration is a relatively unexplored, but active area of investigation”

    From Mitochondrial DNA Damage in Substantia Nigra Pars Compacta Astrocytes Exacerbates Dopaminergic Neuron Loss in a 6-Hydroxydopamine Mouse Model of Parkinsonism (2026) · cites this paper as Gollihue and Norris 2020

    The Abstract and Discussion describe astrocytic mitochondria as an increasingly studied contributor to neuronal protection and damage in neurodegenerative disease. They do not establish that this research concerns astrocytic mitochondria specifically in the substantia nigra pars compacta; the Discussion’s substantia nigra example concerns mitochondrial transplantation and neuronal sparing instead. No page numbers are available in our copy. (LLM, conf=0.85)

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Authors
Gollihue, J. L., & Norris, C. M.
Affiliations
University of Kentucky (US)
Corresponding author
Norris, C.M.
ORCID
Norris, C.M.
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2020-05
Volume
59
Pages
101039
ISSN
1568-1637 (ISSN-L)
DOI
10.1016/j.arr.2020.101039
PMC
PMC7422487
OpenAlex
W3006919153
Cited by
93
References
19
Citations by year
2026: 15 · 2025: 20 · 2024: 19 · 2023: 17 · 2022: 11 · 2021: 9 · 2020: 2
FWCI
0.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Ageing Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
Foundation for the National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
astrocytes, mitochondrial function, neurodegenerative diseases, astrocyte activation, astrocyte-neuron communication, mitochondrial transfer, mitochondrial transplantation, brain metabolism, synaptic transmission, age-related neurodegeneration, cognitive decline, neuroprotection
MeSH terms
Astrocytes, Brain, Humans, Mitochondria, Neurons, Neurodegenerative Diseases

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