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Cited by 920Effects and risks of endocrine disrupting chemicalsEstrogen and related hormone effectsEpigenetics and DNA Methylation

The DOI matches its Crossref record; 180 of the 181 references it cites were found in a registry or an index.

In vitro molecular mechanisms of bisphenol A action.

Wetherill, Yelena B., Akingbemi, Benson T., Kanno, Jun, McLachlan, John A., Nadal, Angel, Sonnenschein, Carlos, Watson, Cheryl S., Zoeller, R. Thomas, Belcher, Scott M.·2007·Reproductive Toxicology
DOI 10.1016/j.reprotox.2007.05.010
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Abstract

Bisphenol A (BPA, 2,2-bis (4-hydroxyphenyl) propane; CAS# 80-05-7) is a chemical used primarily in the manufacture of polycarbonate plastic, epoxy resins and as a non-polymer additive to other plastics. Recent evidence has demonstrated that human and wildlife populations are exposed to levels of BPA which cause adverse reproductive and developmental effects in a number of different wildlife species and laboratory animal models. However, there are major uncertainties surrounding the spectrum of BPA's mechanisms of action, the tissue-specific impacts of exposures, and the critical windows of susceptibility during which target tissues are sensitive to BPA exposures. As a foundation to address some of those uncertainties, this review was prepared by the "In vitro" expert sub-panel assembled during the "Bisphenol A: An Examination of the Relevance of Ecological, In vitro and Laboratory Animal Studies for Assessing Risks to Human Health" workshop held in Chapel Hill, NC, Nov 28-29, 2006. The specific charge of this expert panel was to review and assess the strength of the published literature pertaining to the mechanisms of BPA action. The resulting document is a detailed review of published studies that have focused on the mechanistic basis of BPA action in diverse experimental models and an assessment of the strength of the evidence regarding the published BPA research.

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Crossref · 10.1016/j.reprotox.2007.05.010

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Research works printed but not linked: 2

  1. Yamashita, 2005, Effect of endocrine disrupters on macrophage functions in vitro, J Uoeh, 27, 1, 10.7888/juoeh.27.1_1 · DOI
  2. Smith, 2005, Exposure to the endocrine disruptor bisphnenol A alters uterine developmental gene expression. In uterine biology and endometriosis, Endometrium

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Metadata

Authors
Wetherill, Y. B., Akingbemi, B. T., Kanno, J., McLachlan, J. A., Nadal, A., Sonnenschein, C., Watson, C. S., Zoeller, R. T., & Belcher, S. M.
Affiliations
  • Harvard University (US)
  • Auburn University (US)
  • National Institute of Health Sciences (JP)
  • Tulane University (US)
  • Tufts University (US)
  • The University of Texas Medical Branch at Galveston (US)
  • University of Massachusetts Amherst (US)
  • University of Cincinnati (US)
Corresponding author
Belcher, Scott M.
ORCID
Venue
Reproductive Toxicology
Publisher
Elsevier BV
Published
2007-08
Volume
24
Issue
2
Pages
178-198
ISSN
0890-6238 (ISSN-L)
DOI
10.1016/j.reprotox.2007.05.010
OpenAlex
W2001085078
Cited by
920
References
181
Citations by year
2026: 16 · 2025: 28 · 2024: 36 · 2023: 30 · 2022: 52 · 2021: 54 · 2020: 71 · 2019: 64 · 2018: 64 · 2017: 71 · 2016: 72 · 2015: 65 · 2014: 57 · 2013: 51 · 2012: 55
FWCI
3.22
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Reproductive Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Environmental Health Sciences (P30ES006096, T32ES007069, R01ES015145, T32 ES07069-26, P30 ES-06096)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
bisphenol A, endocrine disruption, molecular mechanisms of action, reproductive toxicity, developmental toxicity, tissue-specific effects, polymer additives, evidence evaluation, in vitro studies
MeSH terms
Bisphenol A Compounds, Animals, Benzhydryl Compounds, Dose-Response Relationship, Drug, Environmental Exposure, Female, Fertility, Humans, Male, Phenols, Reproduction, Endocrine Disruptors

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