The DOI matches its Crossref record; 180 of the 181 references it cites were found in a registry or an index.
In vitro molecular mechanisms of bisphenol A action.
Abstract
Bisphenol A (BPA, 2,2-bis (4-hydroxyphenyl) propane; CAS# 80-05-7) is a chemical used primarily in the manufacture of polycarbonate plastic, epoxy resins and as a non-polymer additive to other plastics. Recent evidence has demonstrated that human and wildlife populations are exposed to levels of BPA which cause adverse reproductive and developmental effects in a number of different wildlife species and laboratory animal models. However, there are major uncertainties surrounding the spectrum of BPA's mechanisms of action, the tissue-specific impacts of exposures, and the critical windows of susceptibility during which target tissues are sensitive to BPA exposures. As a foundation to address some of those uncertainties, this review was prepared by the "In vitro" expert sub-panel assembled during the "Bisphenol A: An Examination of the Relevance of Ecological, In vitro and Laboratory Animal Studies for Assessing Risks to Human Health" workshop held in Chapel Hill, NC, Nov 28-29, 2006. The specific charge of this expert panel was to review and assess the strength of the published literature pertaining to the mechanisms of BPA action. The resulting document is a detailed review of published studies that have focused on the mechanistic basis of BPA action in diverse experimental models and an assessment of the strength of the evidence regarding the published BPA research.
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“It also binds the estrogen membrane receptor (GPER) with high affinity [23] as well as androgen and thyroid receptors [24], [25], [26], [27].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [23]
In the citing paper
“BPA has steroid-like properties and binds to both estrogen receptors (ERα, ERβ) with low affinity [22], [23].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [23]
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Cites
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Kang, J., Kondo, F., & Katayama, Y. (2006) · Toxicology · doi:10.1016/j.tox.2006.06.009 · Cited by 897
Research works printed but not linked: 2
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- Smith, 2005, Exposure to the endocrine disruptor bisphnenol A alters uterine developmental gene expression. In uterine biology and endometriosis, Endometrium
Cited by
Sorted by citations
Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Diamanti-Kandarakis, E., Bourguignon, J.-P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Zoeller, R. T., & Gore, A. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0002 · Cited by 4,585
Self-citationHormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
Self-citationHuman exposure to bisphenol A (BPA)
Vandenberg, L. N., Hauser, R. B., Marcus, M., Olea, N., & Welshons, W. V. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.07.010 · Cited by 2,984
EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Self-citationBisphenol A and human health: A review of the literature
Rochester, J. R. (2013) · Reproductive Toxicology · doi:10.1016/j.reprotox.2013.08.008 · Cited by 2,018
Metadata
- Authors
- Wetherill, Y. B., Akingbemi, B. T., Kanno, J., McLachlan, J. A., Nadal, A., Sonnenschein, C., Watson, C. S., Zoeller, R. T., & Belcher, S. M.
- Affiliations
- Harvard University (US)
- Auburn University (US)
- National Institute of Health Sciences (JP)
- Tulane University (US)
- Tufts University (US)
- The University of Texas Medical Branch at Galveston (US)
- University of Massachusetts Amherst (US)
- University of Cincinnati (US)
- Corresponding author
- Belcher, Scott M.
- ORCID
- Venue
- Reproductive Toxicology
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 24
- Issue
- 2
- Pages
- 178-198
- ISSN
- 0890-6238 (ISSN-L)
- OpenAlex
- W2001085078
- Cited by
- 920
- References
- 181
- Citations by year
- 2026: 16 · 2025: 28 · 2024: 36 · 2023: 30 · 2022: 52 · 2021: 54 · 2020: 71 · 2019: 64 · 2018: 64 · 2017: 71 · 2016: 72 · 2015: 65 · 2014: 57 · 2013: 51 · 2012: 55
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Reproductive Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Environmental Health Sciences (P30ES006096, T32ES007069, R01ES015145, T32 ES07069-26, P30 ES-06096)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- bisphenol A, endocrine disruption, molecular mechanisms of action, reproductive toxicity, developmental toxicity, tissue-specific effects, polymer additives, evidence evaluation, in vitro studies
- MeSH terms
- Bisphenol A Compounds, Animals, Benzhydryl Compounds, Dose-Response Relationship, Drug, Environmental Exposure, Female, Fertility, Humans, Male, Phenols, Reproduction, Endocrine Disruptors
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