Cited by 920Effects and risks of endocrine disrupting chemicalsEstrogen and related hormone effectsEpigenetics and DNA Methylation

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In vitro molecular mechanisms of bisphenol A action.

Wetherill, Yelena B., Akingbemi, Benson T., Kanno, Jun, McLachlan, John A., Nadal, Angel, Sonnenschein, Carlos, Watson, Cheryl S., Zoeller, R. Thomas, Belcher, Scott M.·2007·Reproductive Toxicology

DOI 10.1016/j.reprotox.2007.05.010

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Abstract

Bisphenol A (BPA, 2,2-bis (4-hydroxyphenyl) propane; CAS# 80-05-7) is a chemical used primarily in the manufacture of polycarbonate plastic, epoxy resins and as a non-polymer additive to other plastics. Recent evidence has demonstrated that human and wildlife populations are exposed to levels of BPA which cause adverse reproductive and developmental effects in a number of different wildlife species and laboratory animal models. However, there are major uncertainties surrounding the spectrum of BPA's mechanisms of action, the tissue-specific impacts of exposures, and the critical windows of susceptibility during which target tissues are sensitive to BPA exposures. As a foundation to address some of those uncertainties, this review was prepared by the "In vitro" expert sub-panel assembled during the "Bisphenol A: An Examination of the Relevance of Ecological, In vitro and Laboratory Animal Studies for Assessing Risks to Human Health" workshop held in Chapel Hill, NC, Nov 28-29, 2006. The specific charge of this expert panel was to review and assess the strength of the published literature pertaining to the mechanisms of BPA action. The resulting document is a detailed review of published studies that have focused on the mechanistic basis of BPA action in diverse experimental models and an assessment of the strength of the evidence regarding the published BPA research.

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Bisphenol A and Its Biomaterial Monomer Derivatives Alteration of in Vitro Cytochrome P450 Metabolism in Rat, Minipig, and Human
Cannon, J. M., Kostoryz, E. L., Russo, K. A., Smith, R. E., & Yourtee, D. M. (2000) · Biomacromolecules · doi:10.1021/bm005564+ · Cited by 21
Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1 activation
Yamaguchi, H., Zhu, J., Yu, T., Sasaki, K., Umetsu, H., Kidachi, Y., & Ryoyama, K. (2006) · Toxicology · doi:10.1016/j.tox.2006.06.011 · Cited by 21
Inhibitory effect of natural and environmental estrogens on thymic hormone production in thymus epithelial cell culture
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Down-Regulation of Murine Cyp1a-1 in Mouse Hepatoma Hepa-1c1c7 Cells by Bisphenol A
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Mac1 Positive Cells Are Required for Enhancement of Splenocytes Proliferation Caused by Bisphenol A
Masao, G. O. T. O., Ono, H., Takano‐Ishikawa, Y., Shinmoto, H., & Yoshida, M. (2004) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.68.263 · Cited by 9
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1 of the 181 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Yamashita, 2005, Effect of endocrine disrupters on macrophage functions in vitro, J Uoeh, 27, 1, 10.7888/juoeh.27.1_1 · DOI
Smith, 2005, Exposure to the endocrine disruptor bisphnenol A alters uterine developmental gene expression. In uterine biology and endometriosis, Endometrium

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Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Diamanti-Kandarakis, E., Bourguignon, J.-P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Zoeller, R. T., & Gore, A. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0002 · Cited by 4,585
Self-citation
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
Self-citation
Human exposure to bisphenol A (BPA)
Vandenberg, L. N., Hauser, R. B., Marcus, M., Olea, N., & Welshons, W. V. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.07.010 · Cited by 2,984
EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Self-citation
Bisphenol A and human health: A review of the literature
Rochester, J. R. (2013) · Reproductive Toxicology · doi:10.1016/j.reprotox.2013.08.008 · Cited by 2,018

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Authors: Wetherill, Y. B., Akingbemi, B. T., Kanno, J., McLachlan, J. A., Nadal, A., Sonnenschein, C., Watson, C. S., Zoeller, R. T., & Belcher, S. M.
Affiliations: Harvard University (US)
Auburn University (US)
National Institute of Health Sciences (JP)
Tulane University (US)
Tufts University (US)
The University of Texas Medical Branch at Galveston (US)
University of Massachusetts Amherst (US)
University of Cincinnati (US)
Corresponding author: Belcher, Scott M.
ORCID: Akingbemi, Benson T.
Kanno, Jun
McLachlan, John A.
Sonnenschein, Carlos
Zoeller, R. Thomas
Belcher, Scott M.
Venue: Reproductive Toxicology
Publisher: Elsevier BV
Published: 2007-08
Volume: 24
Issue: 2
Pages: 178-198
ISSN: 0890-6238 (ISSN-L)
DOI: 10.1016/j.reprotox.2007.05.010
OpenAlex: W2001085078
Cited by: 920
References: 181
Citations by year: 2026: 16 · 2025: 28 · 2024: 36 · 2023: 30 · 2022: 52 · 2021: 54 · 2020: 71 · 2019: 64 · 2018: 64 · 2017: 71 · 2016: 72 · 2015: 65 · 2014: 57 · 2013: 51 · 2012: 55
FWCI: 3.22
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Reproductive Toxicology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Environmental Health Sciences (P30ES006096, T32ES007069, R01ES015145, T32 ES07069-26, P30 ES-06096)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: bisphenol A, endocrine disruption, molecular mechanisms of action, reproductive toxicity, developmental toxicity, tissue-specific effects, polymer additives, evidence evaluation, in vitro studies
MeSH terms: Bisphenol A Compounds, Animals, Benzhydryl Compounds, Dose-Response Relationship, Drug, Environmental Exposure, Female, Fertility, Humans, Male, Phenols, Reproduction, Endocrine Disruptors

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In vitro molecular mechanisms of bisphenol A action.

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