The DOI matches its Crossref record; 200 of the 203 references it cites were found in a registry or an index.
Bisphenol A and human health: A review of the literature
Abstract
There is growing evidence that bisphenol A (BPA) may adversely affect humans. BPA is an endocrine disruptor that has been shown to be harmful in laboratory animal studies. Until recently, there were relatively few epidemiological studies examining the relationship between BPA and health effects in humans. However, in the last year, the number of these studies has more than doubled. A comprehensive literature search found 91 studies linking BPA to human health; 53 published within the last year. This review outlines this body of literature, showing associations between BPA exposure and adverse perinatal, childhood, and adult health outcomes, including reproductive and developmental effects, metabolic disease, and other health effects. These studies encompass both prenatal and postnatal exposures, and include several study designs and population types. While it is difficult to make causal links with epidemiological studies, the growing human literature correlating environmental BPA exposure to adverse effects in humans, along with laboratory studies in many species including primates, provides increasing support that environmental BPA exposure can be harmful to humans, especially in regards to behavioral and other effects in children.
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“These memory changes in rodents and primates are usually accompanied by loss of dendritic spines in the medial prefrontal cortex and hippocampus,[[qv: 5b,9]]”
From Bisphenol A Impairs Synaptic Plasticity by Both Pre‐ and Postsynaptic Mechanisms (2017) · cites this paper as [9]
Citations
Cites
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans
Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., An, S. S., Hester, J. M., Bailey, J. N. C., Bostrom, M. A., Rudock, M. E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029202 · Cited by 1,811
Exposure of the U.S. Population to Bisphenol A and 4- tertiary -Octylphenol: 2003–2004
Calafat, A. M., Ye, X., Wong, L.-Y., Reidy, J. A., & Needham, L. L. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.10753 · Cited by 1,743
Decrease in anogenital distance among male infants with prenatal phthalate exposure
Swan, S. H., Main, K. M., Liu, F., Stewart, S. L., Kruse, R. L., Calafat, A. M., Mao, C. S., Redmon, J. B., Ternand, C. L., Sullivan, S., et al. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8100 · Cited by 1,586
Lang, I. (2008) · JAMA · doi:10.1001/jama.300.11.1303 · Cited by 1,479
Saal, F. S. V., & Hughes, C. L. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7713 · Cited by 1,174
In vivo effects of bisphenol A in laboratory rodent studies
Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.004 · Cited by 1,147
Metabolism and Kinetics of Bisphenol A in Humans at Low Doses Following Oral Administration
Völkel, W., Colnot, T., Csanády, G. A., Filser, J. G., & Dekant, W. (2002) · Chemical Research in Toxicology · doi:10.1021/tx025548t · Cited by 1,039
Urinary Concentrations of Bisphenol A and 4-Nonylphenol in a Human Reference Population
Calafat, A. M., Kuklenyik, Z., Reidy, J. A., Caudill, S. P., Ekong, J., & Needham, L. L. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7534 · Cited by 1,031
Research works printed but not linked: 2
- Bailin, 2008, Public awareness drives market for safer alternatives: bisphenol A market analysis report, IEHN, 1
- FDA. CFR part 177. Indirect food additives polymers. Final rule. [Docket No. FDA-2012-F-0031]. Fed Regist 2012;77:41899–902.
Cited by
Sorted by citations
EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Bisphenol Analogues Other Than BPA: Environmental Occurrence, Human Exposure, and Toxicity—A Review
Chen, D., Kannan, K., Tan, H., Zheng, Z., Feng, Y.-L., Wu, Y., & Widelka, M. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.5b05387 · Cited by 1,704
Rochester, J. R., & Bolden, A. L. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1408989 · Cited by 1,540
Self-citationLa Merrill, M. A., Vandenberg, L. N., Smith, M. T., Goodson, W., Browne, P., Patisaul, H. B., Guyton, K. Z., Kortenkamp, A., Cogliano, V. J., Woodruff, T. J., et al. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0273-8 · Cited by 1,005
Global Assessment of Bisphenol A in the Environment
Corrales, J., Kristofco, L. A., Steele, W. B., Yates, B. S., Breed, C. S., Williams, E. S., & Brooks, B. W. (2015) · Dose-Response · doi:10.1177/1559325815598308 · Cited by 814
Metadata
- Authors
- Rochester, J. R.
- Corresponding author
- Rochester, Johanna R.
- Venue
- Reproductive Toxicology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 42
- Pages
- 132-155
- ISSN
- 0890-6238 (ISSN-L)
- OpenAlex
- W2162830803
- Cited by
- 2,018
- References
- 203
- Citations by year
- 2026: 159 · 2025: 146 · 2024: 177 · 2023: 142 · 2022: 187 · 2021: 188 · 2020: 191 · 2019: 188 · 2018: 164 · 2017: 146 · 2016: 141 · 2015: 112 · 2014: 68 · 2013: 6
- FWCI
- 12.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Reproductive Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- The Arkansas Community Foundation
- The Winslow Foundation
- The Johnson Family Foundation
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
- Keywords
- bisphenol A, endocrine disruptors, human health effects, prenatal exposure, postnatal exposure, reproductive effects, developmental effects, metabolic disorders, child health outcomes, perinatal outcomes, environmental exposure
- MeSH terms
- Bisphenol A Compounds, Animals, Benzhydryl Compounds, Humans, Metabolic Diseases, Phenols, Reproduction, Endocrine Disruptors
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