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Bisphenol A and human health: A review of the literature
Abstract
There is growing evidence that bisphenol A (BPA) may adversely affect humans. BPA is an endocrine disruptor that has been shown to be harmful in laboratory animal studies. Until recently, there were relatively few epidemiological studies examining the relationship between BPA and health effects in humans. However, in the last year, the number of these studies has more than doubled. A comprehensive literature search found 91 studies linking BPA to human health; 53 published within the last year. This review outlines this body of literature, showing associations between BPA exposure and adverse perinatal, childhood, and adult health outcomes, including reproductive and developmental effects, metabolic disease, and other health effects. These studies encompass both prenatal and postnatal exposures, and include several study designs and population types. While it is difficult to make causal links with epidemiological studies, the growing human literature correlating environmental BPA exposure to adverse effects in humans, along with laboratory studies in many species including primates, provides increasing support that environmental BPA exposure can be harmful to humans, especially in regards to behavioral and other effects in children.
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“These memory changes in rodents and primates are usually accompanied by loss of dendritic spines in the medial prefrontal cortex and hippocampus,[[qv: 5b,9]]”
From Bisphenol A Impairs Synaptic Plasticity by Both Pre‐ and Postsynaptic Mechanisms (2017) · cites this paper as [9]
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Re: Association of Exposure to Phenols and Idiopathic Male Infertility
Niederberger, C. (2013) · The Journal of Urology · doi:10.1016/j.juro.2013.07.074 · Cited by 10
Flagged first, then by citations
3 of the 203 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Bailin, 2008, Public awareness drives market for safer alternatives: bisphenol A market analysis report, IEHN, 1
- FDA. CFR part 177. Indirect food additives polymers. Final rule. [Docket No. FDA-2012-F-0031]. Fed Regist 2012;77:41899–902.
Cited by
Sorted by citations
EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Bisphenol Analogues Other Than BPA: Environmental Occurrence, Human Exposure, and Toxicity—A Review
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Rochester, J. R., & Bolden, A. L. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1408989 · Cited by 1,540
Self-citationLa Merrill, M. A., Vandenberg, L. N., Smith, M. T., Goodson, W., Browne, P., Patisaul, H. B., Guyton, K. Z., Kortenkamp, A., Cogliano, V. J., Woodruff, T. J., et al. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0273-8 · Cited by 1,005
Global Assessment of Bisphenol A in the Environment
Corrales, J., Kristofco, L. A., Steele, W. B., Yates, B. S., Breed, C. S., Williams, E. S., & Brooks, B. W. (2015) · Dose-Response · doi:10.1177/1559325815598308 · Cited by 814
Metadata
- Authors
- Rochester, J. R.
- Corresponding author
- Rochester, Johanna R.
- Venue
- Reproductive Toxicology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 42
- Pages
- 132-155
- ISSN
- 0890-6238 (ISSN-L)
- OpenAlex
- W2162830803
- Cited by
- 2,018
- References
- 203
- Citations by year
- 2026: 159 · 2025: 146 · 2024: 177 · 2023: 142 · 2022: 187 · 2021: 188 · 2020: 191 · 2019: 188 · 2018: 164 · 2017: 146 · 2016: 141 · 2015: 112 · 2014: 68 · 2013: 6
- FWCI
- 12.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Reproductive Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- The Arkansas Community Foundation
- The Winslow Foundation
- The Johnson Family Foundation
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
- Keywords
- bisphenol A, endocrine disruptors, human health effects, prenatal exposure, postnatal exposure, reproductive effects, developmental effects, metabolic disorders, child health outcomes, perinatal outcomes, environmental exposure
- MeSH terms
- Bisphenol A Compounds, Animals, Benzhydryl Compounds, Humans, Metabolic Diseases, Phenols, Reproduction, Endocrine Disruptors
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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