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The effects of electronic cigarette vapor on placental trophoblast cell function

Raez-Villanueva, Sergio, Ma, Christina, Kleiboer, Sarah, Holloway, Alison C.·2018·Reproductive Toxicology
DOI 10.1016/j.reprotox.2018.07.084
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Abstract

Despite evidence that maternal smoking is associated with numerous adverse outcomes, 10-35% of women still smoke during pregnancy. Recently, many smokers have turned to electronic cigarettes (e-cigarettes) as a smoking cessation tool. However, there is considerable uncertainty regarding their safety for use during pregnancy. The goal of this study was to examine the effects of e-cigarette vapour on placental trophoblast function. HTR-8/SVneo cells were exposed to unflavored e-cigarette vapour-conditioned media with and without nicotine to assess cell viability, proliferation, migration (wound healing assay), invasion (transwell extracellular matrix invasion assay), and tube formation, a surrogate for angiogenesis. While there was no effect on cell viability, proliferation or migration (all p > 0.05), e-cigarette conditioned media significantly reduced trophoblast invasion and tube formation; these effects could not be solely attributed to the presence of nicotine. These results suggest that an evaluation of the safety of e-cigarette use during pregnancy is urgently required.

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Metadata

Authors
Raez-Villanueva, S., Ma, C., Kleiboer, S., & Holloway, A. C.
ORCID
Venue
Reproductive Toxicology
Publisher
Elsevier BV
Published
2018-10
Volume
81
Pages
115-121
ISSN
0890-6238
DOI
10.1016/j.reprotox.2018.07.084
Cited by
30
References
3
Language
en
Licence
Funders
Canadian Institutes of Health Research (155981)

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