Sex Differences in the Pulmonary System Influence the Integrative Response to Exercise
Abstract
Healthy women have proportionally smaller lungs and airways compared with height-matched men. These anatomical sex-based differences result in greater mechanical ventilatory constraints and may influence the integrative response to exercise. Our review will examine this hypothesis in healthy humans in the context of dynamic whole-body exercise.
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Males have superior cardiovascular and respiratory function compared with females, with larger blood and heart volumes, higher hemoglobin concentration, greater cross-sectional area of the trachea and lower oxygen cost of respiration.
“superior cardiovascular and respiratory function, with larger blood and heart volumes, higher hemoglobin concentration, greater cross-sectional area of the trachea and lower oxygen cost of respiration [3, 4, 39, 40].”
From Transgender Women in the Female Category of Sport: Perspectives on Testosterone Suppression and Performance Advantage (2021) · cites this paper as [39]
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- Authors
- Dominelli, P. B., Molgat-Seon, Y., & Sheel, A. W.
- Affiliations
- Mayo Clinic (US)
- University of British Columbia (CA)
- Corresponding author
- Dominelli, Paolo B.
- Venue
- Exercise and Sport Sciences Reviews
- Published
- 2019-02-26
- Volume
- 47
- Issue
- 3
- Pages
- 142-150
- ISSN
- 0091-6331 (ISSN-L)
- 1538-3008
- OpenAlex
- W2921235096
- Cited by
- 68
- References
- 64
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 6 · 2023: 11 · 2022: 15 · 2021: 9 · 2020: 9 · 2019: 3 · 2018: 1
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Exercise and Sport Sciences Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- sex differences, respiratory system, lung size, airway dimensions, ventilatory constraints, exercise response, whole-body exercise, respiratory mechanics, women
- MeSH terms
- Aging, Hypoxia, Dyspnea, Female, Humans, Male, Oxygen, Physical Fitness, Regional Blood Flow, Respiratory Muscles, Respiratory System, Respiratory Physiological Phenomena, Sex Characteristics, Gonadal Steroid Hormones, Work of Breathing, Exercise, Muscle Fatigue, Body Size
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