Cited by 68Cardiovascular and exercise physiologySex and Gender in HealthcareSports Performance and Training

Sex Differences in the Pulmonary System Influence the Integrative Response to Exercise

Dominelli, Paolo B., Molgat-Seon, Yannick, Sheel, A. William·2019·Exercise and Sport Sciences Reviews

Abstract

Healthy women have proportionally smaller lungs and airways compared with height-matched men. These anatomical sex-based differences result in greater mechanical ventilatory constraints and may influence the integrative response to exercise. Our review will examine this hypothesis in healthy humans in the context of dynamic whole-body exercise.

Integrity signals

Registry

Crossref · 10.1249/jes.0000000000000188

Cites

64 of 64 references verified0 citation errors · 0 not checkable

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  • Males have superior cardiovascular and respiratory function compared with females, with larger blood and heart volumes, higher hemoglobin concentration, greater cross-sectional area of the trachea and lower oxygen cost of respiration.

    “superior cardiovascular and respiratory function, with larger blood and heart volumes, higher hemoglobin concentration, greater cross-sectional area of the trachea and lower oxygen cost of respiration [3, 4, 39, 40].”

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Authors
Dominelli, P. B., Molgat-Seon, Y., & Sheel, A. W.
Affiliations
  • Mayo Clinic (US)
  • University of British Columbia (CA)
Corresponding author
Dominelli, Paolo B.
Venue
Exercise and Sport Sciences Reviews
Published
2019-02-26
Volume
47
Issue
3
Pages
142-150
ISSN
  • 0091-6331 (ISSN-L)
  • 1538-3008
OpenAlex
W2921235096
Cited by
68
References
64
Citations by year
2026: 5 · 2025: 9 · 2024: 6 · 2023: 11 · 2022: 15 · 2021: 9 · 2020: 9 · 2019: 3 · 2018: 1
FWCI
1.85
Type
journal article
Language
en
Open access
closed
Locations
  • Exercise and Sport Sciences Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
sex differences, respiratory system, lung size, airway dimensions, ventilatory constraints, exercise response, whole-body exercise, respiratory mechanics, women
MeSH terms
Aging, Hypoxia, Dyspnea, Female, Humans, Male, Oxygen, Physical Fitness, Regional Blood Flow, Respiratory Muscles, Respiratory System, Respiratory Physiological Phenomena, Sex Characteristics, Gonadal Steroid Hormones, Work of Breathing, Exercise, Muscle Fatigue, Body Size

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