Cited by 32Cardiac Arrest and ResuscitationHeart Rate Variability and Autonomic ControlCardiac electrophysiology and arrhythmias

Late heartbeat-evoked potentials are associated with survival after cardiac arrest

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Schulz, André, Stammet, Pascal, Dierolf, Angelika M., Vögele, Claus, Beyenburg, Stefan, Werer, Christophe, Devaux, Yvan·2018·Resuscitation

Abstract

Rationale Cardiac arrest (CA) is a serious condition characterized by high mortality rates, even after initial successful resuscitation, mainly due to neurological damage. Whether brain-heart communication is associated with outcome after CA is unknown. Heartbeat-evoked brain potentials (HEPs) represent neurophysiological indicators of brain-heart communication. The aim of this study was to address the association between HEPs and survival after CA.Methods HEPs were calculated from resting EEG/ECG in 55 CA patients 24 h after resuscitation. All patients were treated with targeted temperature management and a standardized sedation protocol during assessment. We investigated the association between HEP amplitude (180-320 ms, 455-595 ms, 860-1000 ms) and 6-month survival.Results Twenty-five of 55 patients (45%) were still alive at 6-month follow-up. Survivors showed a higher HEP amplitude at frontopolar and frontal electrodes in the late HEP interval than non-survivors. This effect remained significant after controlling for between-group differences in terms of age, Fentanyl dose, and time lag between resuscitation and EEG assessment. There were no group differences in heart rate or heart rate variability.Conclusion Brain-heart communication, as reflected by HEPs, is associated with survival after CA. Future studies should address the brain-heart axis in CA.

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Crossref · 10.1016/j.resuscitation.2018.02.009

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  • Heartbeat evoked potentials following resuscitation after cardiac arrest are larger in survivors than non-survivors at 6-month follow-up.

    “Heartbeat evoked potentials following resuscitation after cardiac arrest have also been found to be larger in survivors than non-survivors at 6 month follow-up (Schulz et al., 2018)”

    From Atypical interoception as a common risk factor for psychopathology: A review (2021) · cites this paper as Schulz et al., 2018

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Authors
Schulz, A., Stammet, P., Dierolf, A. M., Vögele, C., Beyenburg, S., Werer, C., & Devaux, Y.
Affiliations
  • University of Luxembourg (LU)
  • Centre Hospitalier de Luxembourg (LU)
  • Luxembourg Institute of Health (LU)
Corresponding author
Schulz, André
Venue
Resuscitation
Publisher
Elsevier BV
Published
2018-05
Volume
126
Pages
7-13
ISSN
0300-9572 (ISSN-L)
OpenAlex
W2789311280
Cited by
32
References
41
Citations by year
2026: 6 · 2025: 8 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 1
FWCI
2.75
Type
journal article
Language
en
Open access
Locations
  • Resuscitation (publishedVersion)
  • PubMed (publishedVersion)
  • Open Repository and Bibliography (University of Luxembourg) (submittedVersion, cc-by-nc-sa)
Funders
  • Research Support Department of the University of Luxembourg
  • Society for Research on Cardiovascular Diseases
  • Jacqueline Kieffer and Loredana Jacobs for their meticulous work on sample collection and data extraction of the medical files
Topics
  • Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
cardiac arrest, heartbeat-evoked potentials, survival after cardiac arrest, targeted temperature management, brain-heart axis
MeSH terms
Adult, Aged, Electrocardiography, Electroencephalography, Evoked Potentials, Female, Heart Arrest, Heart Rate, Humans, Hypothermia, Induced, Male, Middle Aged, Predictive Value of Tests, Registries, Retrospective Studies

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