Late heartbeat-evoked potentials are associated with survival after cardiac arrest
Open accessAbstract
Rationale Cardiac arrest (CA) is a serious condition characterized by high mortality rates, even after initial successful resuscitation, mainly due to neurological damage. Whether brain-heart communication is associated with outcome after CA is unknown. Heartbeat-evoked brain potentials (HEPs) represent neurophysiological indicators of brain-heart communication. The aim of this study was to address the association between HEPs and survival after CA.Methods HEPs were calculated from resting EEG/ECG in 55 CA patients 24 h after resuscitation. All patients were treated with targeted temperature management and a standardized sedation protocol during assessment. We investigated the association between HEP amplitude (180-320 ms, 455-595 ms, 860-1000 ms) and 6-month survival.Results Twenty-five of 55 patients (45%) were still alive at 6-month follow-up. Survivors showed a higher HEP amplitude at frontopolar and frontal electrodes in the late HEP interval than non-survivors. This effect remained significant after controlling for between-group differences in terms of age, Fentanyl dose, and time lag between resuscitation and EEG assessment. There were no group differences in heart rate or heart rate variability.Conclusion Brain-heart communication, as reflected by HEPs, is associated with survival after CA. Future studies should address the brain-heart axis in CA.
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Heartbeat evoked potentials following resuscitation after cardiac arrest are larger in survivors than non-survivors at 6-month follow-up.
“Heartbeat evoked potentials following resuscitation after cardiac arrest have also been found to be larger in survivors than non-survivors at 6 month follow-up (Schulz et al., 2018)”
From Atypical interoception as a common risk factor for psychopathology: A review (2021) · cites this paper as Schulz et al., 2018
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- Authors
- Schulz, A., Stammet, P., Dierolf, A. M., Vögele, C., Beyenburg, S., Werer, C., & Devaux, Y.
- Affiliations
- University of Luxembourg (LU)
- Centre Hospitalier de Luxembourg (LU)
- Luxembourg Institute of Health (LU)
- Corresponding author
- Schulz, André
- Venue
- Resuscitation
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 126
- Pages
- 7-13
- ISSN
- 0300-9572 (ISSN-L)
- OpenAlex
- W2789311280
- Cited by
- 32
- References
- 41
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 1
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- green
- orbilu.uni.lu
- Licence
- cc-by-nc-sa
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Resuscitation (publishedVersion)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Luxembourg) (submittedVersion, cc-by-nc-sa)
- Funders
- Research Support Department of the University of Luxembourg
- Society for Research on Cardiovascular Diseases
- Jacqueline Kieffer and Loredana Jacobs for their meticulous work on sample collection and data extraction of the medical files
- Topics
- Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- cardiac arrest, heartbeat-evoked potentials, survival after cardiac arrest, targeted temperature management, brain-heart axis
- MeSH terms
- Adult, Aged, Electrocardiography, Electroencephalography, Evoked Potentials, Female, Heart Arrest, Heart Rate, Humans, Hypothermia, Induced, Male, Middle Aged, Predictive Value of Tests, Registries, Retrospective Studies
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